Описание: Provides an overall review of all non-peptide PCSK inhibitors so far reported in the literature along with those identified recently for the first time and not yet published. The potential implications of these molecules as biochemical, therapeutical, or clinical agents is also discussed.
Описание: Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. This title discusses a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relevance in cancer patients.
Описание: Provides an overview of angiogenesis processes and discusses the importance of VEGF-C and VEGF-D precursors processing by the proprotein convertases during the activation of VEGFR-2 and VEGFR-3 receptors and the mediation of their functions during angiogenesis, lymphangiogenesis, and tumorigenesis.
Автор: R. Colin Garner; Jan Hradec Название: Biochemistry of Chemical Carcinogenesis ISBN: 1461278562 ISBN-13(EAN): 9781461278566 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The hepatocarcinogenicity of aflatoxin BI in rats, ducks and rainbow trout has been convincingly demonstrated (1). In contrast, adult mice appear to be resistant to the toxic and carcinogenic effects. Newborn and infant mice are more sensitive to the effects of different hepatocarcinogens (2,3) and also to AFB, which induced hepatomas in newborn C57BL/6 x C3H FI I mice (4). A singl dose model of aflatoxin hepatocarcinogenesis was tested in infant C57BL/6 mice. AFBI was administered i.p. on day 7 after birth and the following data were investigated: 1) Changes in the activities of microsomal cytochrome P-450 dependant enzymes and conjugating enzymes in the course of the 20-month-Iong aflatoxin hepa- tocarcinogenesis study. At intervals of 6,8,12,18 and 20 months a ter AFBI administration, the concentrations of cyt P-450 andb and the acti- 5 vities of NADPH-, NADH-cyt c reductase, AOH, ADM, EH and GST were deter- mined. 2) Effect of continually administered diethyldithiocarbamate on the course of aflatoxin carcinogenesis. MATERIALS AND METHODS Aflatoxin BI was prepared biosynthetically in our laboratory and was checked for purity chromatographically, spectrophotometrically and by NMR.
Автор: Lionel A. Poirier Название: Essential Nutrients in Carcinogenesis ISBN: 1461290252 ISBN-13(EAN): 9781461290254 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For more than 50 years, it has been recognized that diet influences cancer formation both in humans and in experimental animals. Subsequent studies showed that the influence of diet on cancer formation was not only very complex, it also did not appear to playa direct causative role in carcinogenesis.
Автор: George G. Skouteris Название: Liver Carcinogenesis ISBN: 3642792170 ISBN-13(EAN): 9783642792175 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Study Institute on Molecular Aspects of Liver Carcinogenesis, held at City of Delphi, Greece, January 8 - 18, 1994
Автор: F.A. Beland; L.G. Cain; J.S. Felton; J.D. Groopman Название: Chemical Carcinogenesis and Mutagenesis I ISBN: 3642747779 ISBN-13(EAN): 9783642747779 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.
Автор: Jonathan J. Li; Sara A. Li; Jan-Ake Gustafsson; Sa Название: Hormonal Carcinogenesis II ISBN: 1461275067 ISBN-13(EAN): 9781461275060 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For those of us who have labored in the field of hormonal carcinogenesis, it has been most gratifying to see its rapid growth and increasing relevance in recent years. Although many factors and forces have contributed to this phenomenon, a few appear particularly significant. Perhaps foremost is the realization that two of the most prevalent cancers which afflict women and men; that is, breast and prostate, have essential hormonal component(s) to their etiologies. This should not surprise us since the high frequency of these cancers in human populations has to date not been attributed to any exogenous physical, environmental, or dietary factor(s). A similar argument may be applied to other less prevalent but equally important cancers including ovarian, endometrial, testicular, cervico- vaginal, pituitary, thyroid, and sex hormone-associated hepatic neoplasms. The Office of Research on Women's Health and many women's interest groups have been instrumental in fostering research and public awareness on women's cancers. Similar concern is beginning to emerge for solely male cancers by other groups. To illustrate an example of the potential pervasive role of hormones in the human, particularly sex hormones, Figure I depicts the endogenous and known exogenous exposures to estrogens and progestins during a woman's lifetime, which may contribute to increased risk for hormonally-associated cancers . . = iii M. A. P. _ GI en 2 PoOlmenopauoal EstrogDn Proge. tln GI en J\ Ovulatory _ 2 Cyel. iii W DES EIP Menotr". 1 Ol, order.
Автор: A. Cockburn; L. Smith Название: Nongenotoxic Carcinogenesis ISBN: 3662030241 ISBN-13(EAN): 9783662030240 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The clarity of the view that all carcinogens act by mutating DNA, origin- ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer.
Автор: C.F. Arlett; Colin S. Cooper; Philip L. Grover; D. Название: Chemical Carcinogenesis and Mutagenesis II ISBN: 3642747809 ISBN-13(EAN): 9783642747809 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.
Автор: Robert C. Brown; John A. Hoskins; Neil F. Johnson Название: Mechanisms in Fibre Carcinogenesis ISBN: 1468413651 ISBN-13(EAN): 9781468413656 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ARW held in Albuquerque, New Mexico, October 22--25, 1990
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