Chemical Carcinogenesis and Mutagenesis II, C.F. Arlett; Colin S. Cooper; Philip L. Grover; D.

Автор: Trevor M. Penning
Название: Chemical Carcinogenesis
ISBN: 1617797294 ISBN-13(EAN): 9781617797293
Издательство: Springer
Рейтинг:
Цена: 28732.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Presenting the current advances in chemical carcinogenesis, this volume promotes the view that the chemical alteration of DNA is a route cause of many cancers. Topics include the multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action.

Автор: Gotthard Schettler; Dietrich Schm?hl; Thomas Klenn
Название: Risk Assessment in Chemical Carcinogenesis
ISBN: 3540541497 ISBN-13(EAN): 9783540541493
Издательство: Springer
Рейтинг:
Цена: 18167.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The essays in this book discuss the role that chemicalagents in the environment play in the development of cancer. Thus, it gives information toimprove our understanding ofcarcinogenesis and how to prevent it. The essays wereoriginally presented at an international symposium.

Автор: Frederic J. Burns
Название: Radiation Carcinogenesis and DNA Alterations
ISBN: 1468452711 ISBN-13(EAN): 9781468452716
Издательство: Springer
Рейтинг:
Цена: 6986.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Since breakage of the DNA is one of the principal ways that ion- izing radiation affects mammalian cells, these new molecular ideas sug- gest ways that radiation-induced DNA breaks might be involved as initial events in carcinogenesis.

Автор: F.A. Beland; L.G. Cain; J.S. Felton; J.D. Groopman
Название: Chemical Carcinogenesis and Mutagenesis I
ISBN: 3642747779 ISBN-13(EAN): 9783642747779
Издательство: Springer
Рейтинг:
Цена: 16979.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.

Автор: Frederick F. Becker
Название: Etiology: Chemical and Physical Carcinogenesis
ISBN: 1461566002 ISBN-13(EAN): 9781461566007
Издательство: Springer
Рейтинг:
Цена: 16979.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Although great strides have been made toward those goals, as evidenced by a number of new chapters and the new information gathered into others, and although the achievement of those goals sometimes appears but a tantalizing experiment away, none have been achieved.

Автор: Kendric Smith
Название: Aging, Carcinogenesis, and Radiation Biology
ISBN: 1475716648 ISBN-13(EAN): 9781475716641
Издательство: Springer
Рейтинг:
Цена: 6986.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: A summary of data on natural adducts to DNA thus serves to introduce the subject of the radiation and chemical enhancement of DNA adduct formation.

Автор: A. Cockburn; L. Smith
Название: Nongenotoxic Carcinogenesis
ISBN: 3662030241 ISBN-13(EAN): 9783662030240
Издательство: Springer
Рейтинг:
Цена: 6986.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The clarity of the view that all carcinogens act by mutating DNA, origin- ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer.

Автор: A. Kappas
Название: Mechanisms of Environmental Mutagenesis-Carcinogenesis
ISBN: 1461366984 ISBN-13(EAN): 9781461366980
Издательство: Springer
Рейтинг:
Цена: 6986.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Recent findings, techniques and methodologies in the area of biomonitoring of humans exposed to environmental mutagens-carcinogens were presented and considerable attention was also paid to the aspects and issues of collaborative environmental policy.

Автор: Yusaku Tagashira
Название: P-450 and Chemical Carcinogenesis
ISBN: 1468450328 ISBN-13(EAN): 9781468450323
Издательство: Springer
Рейтинг:
Цена: 6986.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book is one of a GANN Monograph on Cancer Research series and is based on a Japanese Cancer Association-sponsored symposium entitled "Multiplicity of Chemical Carcinogen-Activating Enzymes* with Particular Emphasis on Cytochrome P-450" which was held in Tokyo on November 21, 1983.

Автор: J. Clemmesen; A. Waring; D.M. Conning; D. Henschle
Название: Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis
ISBN: 3540095845 ISBN-13(EAN): 9783540095842
Издательство: Springer
Рейтинг:
Цена: 18167.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al., 1967; Magee et al., 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al- kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least 12 sites within the DNA molecule (Lawley, 1976; Singer, 1976; Pegg, 1977a). Al- though alkylation at the 7-position of guanine is the most extensive reaction with the DNA bases and provides a reliable measurement of the degree of interaction with the carcinogen (Swann and Magee, 1968, 1971), recent experiments have suggested that alkylation of oxygen atoms may be the critical reaction (Goth and Rajewsky, 1974; Margison and Kleihues, 1975; Nicoll et aI., 1975; Pegg, 1977a). These laboratories have observed a correlation between the production and persistence of 06-alkyl- guanine and the occurrence oftumors in a variety of organs of rodents exposed to N-ni- troso-carcinogens. It has, therefore, been suggested that the ability of tissues to catalyze the removal of 06-alkylguanine from DNA may provide a protective mechanism against carcinogenesis.

Автор: R. Colin Garner; Jan Hradec
Название: Biochemistry of Chemical Carcinogenesis
ISBN: 1461278562 ISBN-13(EAN): 9781461278566
Издательство: Springer
Рейтинг:
Цена: 12157.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The hepatocarcinogenicity of aflatoxin BI in rats, ducks and rainbow trout has been convincingly demonstrated (1). In contrast, adult mice appear to be resistant to the toxic and carcinogenic effects. Newborn and infant mice are more sensitive to the effects of different hepatocarcinogens (2,3) and also to AFB, which induced hepatomas in newborn C57BL/6 x C3H FI I mice (4). A singl dose model of aflatoxin hepatocarcinogenesis was tested in infant C57BL/6 mice. AFBI was administered i.p. on day 7 after birth and the following data were investigated: 1) Changes in the activities of microsomal cytochrome P-450 dependant enzymes and conjugating enzymes in the course of the 20-month-Iong aflatoxin hepa- tocarcinogenesis study. At intervals of 6,8,12,18 and 20 months a ter AFBI administration, the concentrations of cyt P-450 andb and the acti- 5 vities of NADPH-, NADH-cyt c reductase, AOH, ADM, EH and GST were deter- mined. 2) Effect of continually administered diethyldithiocarbamate on the course of aflatoxin carcinogenesis. MATERIALS AND METHODS Aflatoxin BI was prepared biosynthetically in our laboratory and was checked for purity chromatographically, spectrophotometrically and by NMR.

Автор: Max Costa
Название: Metal Carcinogenesis Testing
ISBN: 148994091X ISBN-13(EAN): 9781489940919
Издательство: Springer
Рейтинг:
Цена: 13974.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Metal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci- nogenic metals and their compounds.