Molecular Pathology of Alzheimer`s Disease, Rudy Castellani, George Perry
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Описание: Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). Abeta Peptide and Alzheimer’s Disease is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinsons and Huntingtons. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases.
Автор: Derreumaux Philippe Название: Alzheimer`s Disease: Insights into Low Molecular Weight and ISBN: 1848167547 ISBN-13(EAN): 9781848167544 Издательство: World Scientific Publishing Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Alzheimer`s disease is the most common form of senile dementia, affecting more than 24 million people worldwide. This book provides a panoramic view across in vitro and in vivo studies along with computer simulations, designed to increase the readers` understanding of oligomerisation and fibril formation.
Автор: Antony D. Kidman; John K. Tomkins; Carol A. Morris Название: Molecular Pathology of Nerve and Muscle ISBN: 1461297796 ISBN-13(EAN): 9781461297796 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It was direced towards an understanding of the molecular neuropathology of muscle and nerve under a wide variety of conditions that may be induced by external agents or genetic lesions. This section was expanded to explore the control of muscle function in nerves, including a discussion on cross reinnervation.
Автор: Antony D. Kidman; John K. Tomkins; Carol A. Morris Название: Molecular Pathology of Nerve and Muscle ISBN: 0896030571 ISBN-13(EAN): 9780896030572 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It was direced towards an understanding of the molecular neuropathology of muscle and nerve under a wide variety of conditions that may be induced by external agents or genetic lesions. This section was expanded to explore the control of muscle function in nerves, including a discussion on cross reinnervation.
Автор: Heiko Braak; Kelly Del Tredici Название: Neuroanatomy and Pathology of Sporadic Alzheimer`s Disease ISBN: 3319126784 ISBN-13(EAN): 9783319126784 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail
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