Описание: Reflecting the significant developments of the past decade, this textbook explains key physical methods in modern biology. Each method is illustrated through real-world examples, alongside background information designed for both physicists and biologists, making this an ideal resource for students in biophysics at science and medical schools.
Описание: This second edition provides updated and expanded chapters covering a broad sampling of useful and current methods in the rapidly developing and expanding field of bioinformatics.
Автор: Craig Nancy Название: Molecular Biology Principles of Genome Function ISBN: 0199658579 ISBN-13(EAN): 9780199658572 Издательство: Oxford Academ Рейтинг: Цена: 9186.00 р. Наличие на складе: Поставка под заказ.
Описание: A fresh, distinctive approach to the teaching of molecular biology. With its focus on key principles, its emphasis on the commonalities that exist between the three kingdoms of life, and its integrated coverage of experimental methods and approaches, Molecular Biology is the perfect companion to any molecular biology course.
Описание: This book takes the novel approach to cover both the sequence and structure analysis of proteins in one volume and from an algorithmic perspective. Key features of the book include:* Provides a comprehensive introduction to the analysis of protein sequence and structure analysis.
Название: G Protein-Coupled Receptors: From Structure to Function ISBN: 1849731837 ISBN-13(EAN): 9781849731836 Издательство: Royal Society of Chemistry Рейтинг: Цена: 35902.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book considers the relationship between structure and function in G protein-coupled receptors (GPCRs) and the implications for drug design.
Автор: Jean-Jacques Lacapere Название: Membrane Protein Structure and Function Characterization ISBN: 1493971492 ISBN-13(EAN): 9781493971497 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this present volume, different approaches are detailed to produce membrane proteins, purify them, study their function, determine their structure, and model them in membrane.
1. Composition and dynamics of the eukaryotic replisome: a brief overview;Stuart A. MacNeill 1.1 Introduction 1.2 Replication origins and the origin recognition complex 1.3 Formation of the pre-RC at origins 1.4 The replisome progression complex 1.5 The replicative polymerases 1.6 Sliding clamp and clamp loader complexes 1.7 Okazaki fragment processing 1.8 Model systems for the studying eukaryotic replication 1.8.1 SV40 1.8.2 Yeast 1.8.3 Xenopus 1.8.4 Archaea 1.8.5 Other model systems 1.9 Conclusions Acknowledgements References
2. Evolutionary diversification of eukaryotic DNA replication machinery; Stephen J. Aves, Yuan Liu and Thomas A. Richards 2.1 Introduction 2.2 Eukaryotic diversity 2.3 Conservation of replisome proteins 2.4 Indispensable replisome proteins 2.5 Replisome proteins present in all eukaryotic supergroups 2.6 Replisome proteins not present in all supergroups 2.7 A complex ancestral replisome 2.8 Conclusions References
3. The origin recognition complex: a biochemical and structural view; Huilin Li and Bruce Stillman 3.1 Introduction 3.2 The S. cerevisiae ORC 3.3 The S. pombe ORC 3.4 The D. melanogaster ORC 3.5 The H. sapiens ORC 3.6 Future perspectives Acknowledgements References
4. Archaeal Orc1/Cdc6 Proteins; Stephen D. Bell 4.1 Introduction 4.2 Origins of DNA replication in the Archaea 4.3 Orc1/Cdc6 Structure 4.4 Structures of Orc1/Cdc6 bound to DNA 4.5 Beyond binding origins - what do Orc1/Cdc6s do?Acknowledgements References
5. Cdt1 and Geminin in DNA replication initiation; Christophe Caillat and Anastassis Perrakis 5.1 Cdt1 and Geminin: a functional preview5.2 The multiple faces of Geminin 5.2.1 Geminin functions in replication licensing 5.2.2 Geminin in the cell cycle 5.2.3 Geminin in cell differentiation 5.3 The structure of Geminin 5.3.1 The N-terminal domain 5.3.2 The coiled-coil domain 5.4 The structure of Cdt1 5.4.1 The N-terminal domain is highly regulated 5.4.2 The structurally conserved winged helix domains 5.4.3 The recruitment of Cdt1 on chromatin 5.5 The Cdt1-Geminin complex 5.5.1 The primary and secondary interfaces 5.5.2 The tertiary interface 5.5.3 Conformational change of the N-terminal domain? 5.6 Models for a Cdt1-Geminin molecular switch 5.7 Conclusions References
6. MCM structure and mechanics: what we have learned from archaeal MCM: Ian M. Slaymaker and Xiaojiang S. Chen 6.1 Introduction 6.2 Complex organization: Hexamers and double hexamers 6.3 Helicase activity 6.3.1 Steric exclusion 6.3.2 Ploughshare 6.3.3 LTag looping model (or strand exclusion) 6.3.4 Rotary pump 6.4 Domains and features of an MCM subunit 6.4.1 N domain 6.4.2 C domain 6.4.2.1 ATP binding pocket 6.4.2.2 Hairpins, helices and inserts 6.4.2.3 Winged helix domain 6.5 Inter- and intra-subunit communication 6.6 Higher-order MCM oligomers 6.7 Conclusions References
7. The Eukaryotic Mcm2-7 Replicative Helicase; Sriram Vijayraghavan and Anthony Schwacha 7.1 Introduction 7.2 The 'Mcm problem' and nonequivalent ATPase active sites 7.3 Discovery of Mcm2-7 helicase activity and the Mcm2/5 gate 7.3.1 Differences in circular ssDNA binding between Mcm2-7 and Mcm467 7.3.2 An in vitro condition that 'closes' Mcm2-7 stimulates its helicase activity 7.3.3 The Mcm2/5 'gate' model - the open conformation and DNA unwinding are mutually exclusive 7.4 The CMG complex 7.4.1 Discovery of the CMG complex 7.4.2 CMG structure - Cdc45 and GINS close the Mcm2/5 gate 7.4.3 Possible regu
Автор: Hieronim Jakubowski Название: Homocysteine in Protein Structure/Function and Human Disease ISBN: 3709117208 ISBN-13(EAN): 9783709117200 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
Автор: D.L. Smith; Z.H. Zaidi Название: Protein Structure — Function Relationship ISBN: 1461380154 ISBN-13(EAN): 9781461380153 Издательство: Springer Рейтинг: Цена: 14673.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Although many pursue understanding of the relationship between protein structure and function for the thrill of pure science, the pay-off in a much broader sense is the ability to manipulate the Earth`s chemistry and biology to improve the quality of life for mankind.
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