Описание: A book useful to postgraduate students and researchers in medicinal chemistry and pharmacology, as well as specialists in the acute brain injury field.
Описание: This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.
Автор: Conn, P. Michael Название: Conn`s Translational Neuroscience ISBN: 0128023813 ISBN-13(EAN): 9780128023815 Издательство: Elsevier Science Рейтинг: Цена: 20212.00 р. Наличие на складе: Нет в наличии.
Описание:
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain, ' with the results providing insight into the underlying basis of many neurological disease processes.
This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.
In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.
A critical examination of translational medicine, when private risk is transferred to the public sector and university research teams become tech startups for global investors.
A global shift has secretly transformed science and medicine. Starting in 2003, biomedical research in the West has been reshaped by the emergence of translational science and medicine--the idea that the aim of research is to translate findings as quickly as possible into medical products. In The Market in Mind, Mark Dennis Robinson charts this shift, arguing that the new research paradigm has turned university research teams into small biotechnology startups and their industry partners into early-stage investment firms. There is also a larger, surprising consequence from this shift: according to Robinson, translational science and medicine enable biopharmaceutical firms, as part of a broader financial strategy, to outsource the riskiest parts of research to nonprofit universities. Robinson examines the implications of this new configuration. What happens, for example, when universities absorb unknown levels of risk? Robinson argues that in the years since the global financial crisis translational science and medicine has brought about "the financialization of health."
Robinson explores such topics as shareholder anxiety and industry retreat from Alzheimer's and depression research; how laboratory research is understood as health innovation even when there is no product; the emergence of investor networking events as crucial for viewing science in a market context; and the place of patients in research decisions. Although translational medicine justifies itself by the goal of relieving patients' suffering, Robinson finds patients' voices largely marginalized in translational neuroscience.
1. Proteomic Analysis of Post-Translational Modifications in Neurobiology
Hongbo Gu, Matthew P. Stokes, and Jeffrey C. Silva
2. A Boronic Acid-based Enrichment for Site-specific Identification of the N-glycoproteome using MS-based Proteomics
Haopeng Xiao, George X. Tang, Weixuan Chen, and Ronghu Wu
3. Site-specific Localization of D-Amino Acids in Bioactive Peptides by Ion Mobility Spectrometry
Chenxi Jia, Christopher B. Lietz, Qing Yu, and Lingjun Li
4. Quantitative Profiling of Reversible Cysteome Modification under Nitrosative Stress
Yue-Ting Wang, Sujeewa C. Piyankarage, and Gregory R. J. Thatcher
5. Label-free LC-MS/MS Comparative Analysis of Protein S-nitrosome in Synaptosomes from Wild Type and APP Transgenic Mice
Monika Zaręba-Koziol, Maciej Lalowski, and Aleksandra Wyslouch-Cieszyńska
6. Proteomics Identification of Redox-Sensitive Nuclear Protein Targets Of Human Thioredoxin 1 from SHSY-5Y Neuroblastoma Cell Line
Mohit Raja Jain, Changgong Wu, Qing Li, Chuanlong Cui, Huacheng Dai, and Hong Li
7. Identification and Quantification of K63-Ubiquitinated Proteins in Neuronal Cells by Hi
gh-
Resolution Mass Spectrometry
Gustavo Monteiro Silva, Wei Wei, Sandhya Manohar, and Christine Vogel
8. Phosphorylation Site Profiling of NG108 Cells Using Quadrupole/Orbitrap Mass
Spectrometry
Fang-Ke Huang, Guoan Zhang, and Thomas A. Neubert
9. Phosphoproteomics of Tyrosine Kinases in the Nervous System
Robert J. Chalkley and
Ralph A. Bradshaw
10. Analysis of PINK1 and CaMKII Substrates Using Mass Spectrometry-Based Proteomics
Yan Li, Lesley A. Kane, Michael A Bemben, and Katherine W Roche
11. Liquid Chromatography-Tandem Mass Spectrometry Analysis of Tau Phosphorylation
Jhoana Mendoza, Georgia Dolios, and Rong Wang
12. Identification of Protease Substrates in Complex Proteomes by iTRAQ-TAILS
Tobias Kockmann, Nathalie Carte, Samu Melkko, and Ulrich auf dem Keller
13. Proteolytic P
rocessing of Neuropeptides
Lloyd D. Fricker
14 Isotope Dilution Analysis of Myelin Basic Protein Degradation after Brain Injury
Andrew K Ottens
15. Identification and Characterization of Protein Post-Translational Modifications by
Differential Fluorescent Labeling
Eric D. Hamlett, Cristina Osorio, and Oscar Alzate
16 Mass
Spectrometric Detection of Detyrosination and Polyglutamyation on the C-Terminal Region of Brain Tubulin
Yasuko Mori, Alu Konno, Mitsutoshi Setou, and Koji Ikegami
17. Determination of polyhydroxybutyrate (PHB) Post-Translational Modifications of Proteins Using Mass Spectrometry
Tong Liu, Wei Chen, Stacey Pan, Chuanlong Cui, Hong Li, and Eleonora Zakharian
Автор: Birrer, Michael Название: Translational Advances in Gynecologic Cancers ISBN: 0128037415 ISBN-13(EAN): 9780128037416 Издательство: Elsevier Science Рейтинг: Цена: 14654.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included.
Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus.
Автор: Maria de los Angeles Robinson-Agramonte Название: Translational Approaches to Autism Spectrum Disorder ISBN: 3319163205 ISBN-13(EAN): 9783319163208 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Among the topic addressed are neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.
Описание: This book highlights major advances in researching a cell`s molecular machinery through analytical, computational, and imaging methods. It focuses on developing biophysical approaches to studying control of gene expression at the translational level.
Автор: Shashi Bala Singh; Nanduri R. Prabhakar; Srinivas Название: Translational Research in Environmental and Occupational Stress ISBN: 8132219279 ISBN-13(EAN): 9788132219279 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged. This field, which is now widely referred to as Translational Research utilizes basic science findings and translates these findings into innovative concepts for the benefit of mankind. This branch of science has evolved into a multidisciplinary juggernaut encompassing all known fields of science as varied as biomedicine, environment, law, economics, sociology, etc. With the ever increasing interest in this branch and the dreams and aspirations that this field can bring, basic science researchers are now taking a bold step into this new realm, merging different fields of knowledge to come up with novel inventions. This book "Translational research in environmental and occupational stress" provides and insight into the research that led to discoveries, inventions and development of novel technologies which will have a tremendous impact on the future of mankind.
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