Описание: A book useful to postgraduate students and researchers in medicinal chemistry and pharmacology, as well as specialists in the acute brain injury field.
Описание: This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.
Автор: Conn, P. Michael Название: Conn`s Translational Neuroscience ISBN: 0128023813 ISBN-13(EAN): 9780128023815 Издательство: Elsevier Science Рейтинг: Цена: 20212.00 р. Наличие на складе: Поставка под заказ.
Описание:
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain, ' with the results providing insight into the underlying basis of many neurological disease processes.
This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.
In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.
Название: Translational neuroscience ISBN: 1489976523 ISBN-13(EAN): 9781489976529 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Chapter 1 - Introduction - Mark H. Tuszynski
Section 1: Molecular Approaches
Chapter 2 - Gene Therapy of CNS Disorders using Recombinant AAV vectors - Giridhar Murlidharan, R. Jude Samulski and Aravind Asokan
Chapter 3 - NGF and BDNF Gene Therapy for Alzheimer's Disease - Alan H. Nagahara and Mark H. Tuszynski
Chapter 4 - GDNF and AADC Gene Therapy for Parkinson's Disease - Krystof Bankiewicz, Waldy San Sebastian, Lluis Samaranch and John Forsayeth
Chapter 5 - GAD Gene Therapy for Parkinson's Disease - Michael G. Kaplitt and Matthew J. During
Chapter 6 - Anti-sense Oligonucleotides
for Amyotrophic Lateral Sclerosis - Wade K. Self and Timothy M. Miller
Chapter 7 - Gene therapy for Inborn Errors of Metabolism: Batten Disease - Dolan Sondhi, Ronald G. Crystal and Stephen M. Kaminsky
Chapter 8 - Gene Therapy for Spinal Cord Injury - Ioana Goganau and Armin Blesch
Chapter 9 - Gene Therapy for Epilepsy - Thomas J. McCown
Chapter 10 - Gene therapy for Pain - Darren Wolfe, David Krisky, James Goss, James Wechuck, Marina Mata and David J. Fink
Section 2: Cellular Approaches
Chapter 11 - Stem Cells for Parkinson's Disease - Andrйs Bratt-Lealand Jeanne F. Loring
quot;serif"">Chapter 12 - Could Stem Cells be used to treat or model Alzheimer's Disease? - Edsel M. Abud and Mathew Blurton-Jones
Chapter 13 - Stem cells for Amyotrophic Late
ral Sclerosis - Anthony Donsante, Lindsey Nicole Urquia and Nicholas M. Boulis
Chapter 14 - Stem cells for Multiple Sclerosis - Pamela Sarkar and Neil Scolding
Chapter 15 - Cell Therapy for Pediatric Disorders of Glia - Joana M. Osorio and Steven A. Goldman
Chapter 16 - Neural Stem Cells for Spinal Cord Injury - Paul Lu, Ruhel Amhad
le="mso-bidi-font-size:12.0pt;font-family: "Times New Roman","serif""> and Mark H. Tuszynski
Chapter 17 - Marrow-derived Mesenchymal Stromal Cells in the Treatment of Stroke - Steve C. Cramer
Chapter 19 - Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer's Disease - Kevin D. Rynearson, Rudolph E. Tanzi and Steven L. Wagner
Chapter 20 - Blocking the Nogo-A signalling pathway to promote regeneration and pla
sticity after spinal cord injury and stroke - tachment: initial; background-size: initial; background-origin: initial; background-clip: initial; background-position: initial; background-repeat: initial;">Anna Magdalena Guzik-Kornacka, Flуra Vajda, Martin E. Schwab
Chapter 21 - Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury - Fengfeng Bei and Zhigang He
Chapter 22 - Voltage-gated ion channels as molecula
r targets for pain - Gerald W. Zamponi, Chongyang Hanand Stephen G. Waxman
Section 4: Activity-Dependent Plasticity and Neurorehabilitation
Chapter 24 - Neural Prostheses for Neurotrauma - Arthur Prochazka
Chapter 25 - Why is Fu
nctional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? - Mary K. Nagai, Cesar Marquez-Chin and Milos R. Popovic
Chapter 26 - Deep Brain Stimulation for Neuropsychiatric Disorders - Ausaf A. Bari, Nicolas Kon Kam King, Nir Lipsman and Andres M. Lozano
Chapter 27 - Novel Interventions for Stroke: Nervous System Cooling - Patrick D. Lyden, Jessica Lamb and Padmesh S. Rajput
A critical examination of translational medicine, when private risk is transferred to the public sector and university research teams become tech startups for global investors.
A global shift has secretly transformed science and medicine. Starting in 2003, biomedical research in the West has been reshaped by the emergence of translational science and medicine--the idea that the aim of research is to translate findings as quickly as possible into medical products. In The Market in Mind, Mark Dennis Robinson charts this shift, arguing that the new research paradigm has turned university research teams into small biotechnology startups and their industry partners into early-stage investment firms. There is also a larger, surprising consequence from this shift: according to Robinson, translational science and medicine enable biopharmaceutical firms, as part of a broader financial strategy, to outsource the riskiest parts of research to nonprofit universities. Robinson examines the implications of this new configuration. What happens, for example, when universities absorb unknown levels of risk? Robinson argues that in the years since the global financial crisis translational science and medicine has brought about "the financialization of health."
Robinson explores such topics as shareholder anxiety and industry retreat from Alzheimer's and depression research; how laboratory research is understood as health innovation even when there is no product; the emergence of investor networking events as crucial for viewing science in a market context; and the place of patients in research decisions. Although translational medicine justifies itself by the goal of relieving patients' suffering, Robinson finds patients' voices largely marginalized in translational neuroscience.
Автор: Birrer, Michael Название: Translational Advances in Gynecologic Cancers ISBN: 0128037415 ISBN-13(EAN): 9780128037416 Издательство: Elsevier Science Рейтинг: Цена: 14654.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included.
Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus.
Автор: Maria de los Angeles Robinson-Agramonte Название: Translational Approaches to Autism Spectrum Disorder ISBN: 3319163205 ISBN-13(EAN): 9783319163208 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Among the topic addressed are neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.
Описание: This book highlights major advances in researching a cell`s molecular machinery through analytical, computational, and imaging methods. It focuses on developing biophysical approaches to studying control of gene expression at the translational level.
Автор: Shashi Bala Singh; Nanduri R. Prabhakar; Srinivas Название: Translational Research in Environmental and Occupational Stress ISBN: 8132219279 ISBN-13(EAN): 9788132219279 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged. This field, which is now widely referred to as Translational Research utilizes basic science findings and translates these findings into innovative concepts for the benefit of mankind. This branch of science has evolved into a multidisciplinary juggernaut encompassing all known fields of science as varied as biomedicine, environment, law, economics, sociology, etc. With the ever increasing interest in this branch and the dreams and aspirations that this field can bring, basic science researchers are now taking a bold step into this new realm, merging different fields of knowledge to come up with novel inventions. This book "Translational research in environmental and occupational stress" provides and insight into the research that led to discoveries, inventions and development of novel technologies which will have a tremendous impact on the future of mankind.
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