`Essentials of cancer genomic, computational approaches and precision medicine, Masood
Автор: Lupski Название: Genomic Disorders. 2006 ISBN: 1588295591 ISBN-13(EAN): 9781588295590 Издательство: Springer Рейтинг: Цена: 10760.00 р. 15372.00-30% Наличие на складе: Есть (1 шт.) Описание: A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.
Автор: Geoffrey S. Ginsburg Название: Genomic and Personalized Medicine ISBN: 0128006811 ISBN-13(EAN): 9780128006818 Издательство: Elsevier Science Рейтинг: Цена: 15157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.
The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.
Provides a comprehensive volume on the translation and implementation of biology into health care provision
Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation
Includes an up-to-date overview on major 'translational events' in genomic and personalized medicine, along with lessons learned
At a ceremony announcing the completion of the first draft of the human genome in 2000, President Bill Clinton declared, "I believe one of the great truths to emerge from this triumphant expedition inside the human genome is that in genetic terms, all human beings, regardless of race, are more than 99.9 percent the same." Yet despite this declaration of unity, biomedical research has focused increasingly on mapping that.1 percent of difference, particularly as it relates to race.
This trend is exemplified by the drug BiDil. Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was originally touted as a pathbreaking therapy to treat heart failure in black patients and help underserved populations. Upon closer examination, however, Jonathan Kahn reveals a far more complex story. At the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked.
Using BiDil as a central case study, Kahn broadly examines the legal and commercial imperatives driving the expanding role of race in biomedicine, even as scientific advances in genomics could render the issue irrelevant. He surveys the distinct politics informing the use of race in medicine and the very real health disparities caused by racism and social injustice that are now being cast as a mere function of genetic difference. Calling for a more reasoned approach to using race in biomedical research and practice, Kahn asks readers to recognize that, just as genetics is a complex field requiring sensitivity and expertise, so too is race, particularly in the field of biomedicine.
Автор: Kishore R. Sakharkar, Meena K. Sakharkar, Ramesh Chandra Название: Post-genomic Approaches in Cancer and Nano Medicine ISBN: 8793102860 ISBN-13(EAN): 9788793102866 Издательство: Taylor&Francis Рейтинг: Цена: 13320.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Understanding the molecular mechanisms of cancer is the key for transforming cancer medicine. Seen in several cancers is a substantial proportion of human genes showing alternative splicing and mis-regulation of Pre-mRNA splicing.
Post-genomic Approaches in Cancer and Nano Medicine further investigates these matters. The first few chapters provide an update on the role of genomics in understanding alternative splicing and targets in cancer pathogenesis. Advances and prospects in applications of nanotechnology for cancer prevention, detection, and treatment are a promising field of research. The subsequent chapters provide insights on how nanotechnology-based therapeutics are moving toward revolutionizing cancer and infectious disease treatment by minimizing toxicity and facilitating targeted delivery of drugs.
Technical topics discussed in the book include: - Alternative splicing and cancer - Cancer imaging - Nanomaterials in infectious diseases - Nanomedicine in oxidative stress and cancer - Nanoparticle based drug delivery systems
Автор: Kishore R. Sakharkar, Meena K. Sakharkar, Ramesh Chandra Название: Post-genomic Approaches in Drug and Vaccine Development ISBN: 8793102844 ISBN-13(EAN): 9788793102842 Издательство: Taylor&Francis Рейтинг: Цена: 13320.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past decade, genome sequencing projects and associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, and understand their role in physiological pathways and associated diseases with the aim of translating these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic, and metabolomic approaches. Post-genomic Approaches to Drug and Vaccine Development focuses on some key advances in the field.
Technical topics discussed in the book include: - Drug discovery - Target identification and prioritization - Hypothesis driven multi-target drug design - Genomics in vaccine development - Gene regulatory networks - Vaccine design and development - Prediction of drug side effects in silico
Автор: Ginsburg, Geoffrey S. Название: Genomic And Precision Medicine ISBN: 0128006838 ISBN-13(EAN): 9780128006832 Издательство: Elsevier Science Рейтинг: Цена: 10309.00 р. Наличие на складе: Поставка под заказ.
Описание: Genomic and Precision Medicine: Neurological Diseases discusses the applications of genome discovery on the broad spectrum of pernicious conditions in this area - movement disorders, autism, epilepsy and depression included. Each chapter will be organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
Автор: Ginsburg, Geoffrey S. Название: Genomic and Precision Medicine ISBN: 0128006854 ISBN-13(EAN): 9780128006856 Издательство: Elsevier Science Рейтинг: Цена: 15319.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care.
One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners.
Presents a comprehensive volume for primary care providers
Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine
Includes a current overview on major opportunities for genomic and personalized medicine in practice
Highlights case studies that illustrate the practical use of genomics in the management in patients
Описание: Bringing the experiences of patients, carers and practitioners to the fore, this book explores how individual and collective futures are crafted through their work and care. The authors chart the different kinds of care and work involved in efforts to personalise cancer medicine, as well as the ways in which benefits and opportunities are unevenly realised and distributed. -- .
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