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Targeted Therapy of Colorectal Cancer Subtypes, Peter Jordan


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Автор: Peter Jordan
Название:  Targeted Therapy of Colorectal Cancer Subtypes
ISBN: 9783030027704
Издательство: Springer
Классификация:

ISBN-10: 3030027708
Обложка/Формат: Hardcover
Страницы: 150
Вес: 0.66 кг.
Дата издания: 2019
Серия: Advances in Experimental Medicine and Biology
Язык: English
Издание: 1st ed. 2018
Иллюстрации: 10 tables, color; 9 illustrations, color; viii, 150 p. 9 illus. in color.
Размер: 262 x 231 x 13
Читательская аудитория: Professional & vocational
Ключевые слова: Cancer Research
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Recent years have increased significantly our understanding of the genetic alterations that can underlie CRC, but also unraveled the molecular heterogeneity of the disease. Although a simple correlation between genetic pathways, histopathological features and clinical outcome cannot be established, the heterogeneity of CRC is also an opportunity for the development of targeted therapeutic approaches, able to treat an individual tumor with higher efficiency and less toxic side effects. One CRC subtype is characterized by high mutation rates (MSI-H), DNA methylation changes (CIMP-H), mutation in the BRAF oncogene and occurrence of serrated adenomas in the proximal colon. Other groups prevail in the distal colon and consist of either adenomatous polyps with chromosomal aberrations (CIN) and WNT pathway activation, or carry frequent KRAS mutation and metabolic deregulation, or have strong mesenchymal and infiltrative characteristics. Characterization of driver-mutation events in these CRC subgroups has led to the development of specific drugs targeting, for example, the MAPK pathway, but initial clinical trials have revealed unexpected response rates. The collection of chapters in this volume address the biology of specific CRC subtypes and how these may be targeted to improve precision therapy and clinical benefit for the patients.
Дополнительное описание: Preface.- Colorectal Cancer Subtypes- the current portrait.- Targeting colon cancers with mutated BRAF and microsatellite instability.- Targeting KRAS mutant CMS3 subtype by metabolic inhibitors.- Targeting the PI3K Signalling as a Therapeutic Strategy in



From Inflammation To Cancer: Advances In Diagnosis And Therapy For Gastrointestinal And Hepatological Diseases  From Inflammation To Cancer: Advances In Diagnosis And Therapy For Gastrointestinal And Hepatological Diseases

Автор: Cho Chi-Hin & Yu Jun
Название: From Inflammation To Cancer: Advances In Diagnosis And Therapy For Gastrointestinal And Hepatological Diseases From Inflammation To Cancer: Advances In Diagnosis And Therapy For Gastrointestinal And Hepatological Diseases
ISBN: 9814343595 ISBN-13(EAN): 9789814343596
Издательство: World Scientific Publishing
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Цена: 19483.00 р.
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Описание: Inflammation and cancer are two major disorders that cause huge concerns in our society. However, what one may not know is that both diseases are closely associated and, in particular, both occur in the gastrointestinal tract and liver. This book describes the mechanics of how inflammation can progress to cancer in these organs.

Genetics of Colorectal Cancer

Автор: John D. Potter; Noralane M. Lindor (Eds.)
Название: Genetics of Colorectal Cancer
ISBN: 0387095675 ISBN-13(EAN): 9780387095677
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Genetic susceptibility refers to how variations in a person`s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This book explores various findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology.

Encyclopedia of Colorectal Cancer: Volume IV (Management and Treatment)

Автор: Young Teresa
Название: Encyclopedia of Colorectal Cancer: Volume IV (Management and Treatment)
ISBN: 1632411377 ISBN-13(EAN): 9781632411372
Издательство: Неизвестно
Цена: 23488.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The challenges and mortality that colorectal cancer accompanies, calls for better and improved methods for patient care and treatment. This book presents the essential work that scientists and experts have under taken in this field covering patient care m

Colorectal Cancer Screening

Автор: Aasma Shaukat; John I. Allen
Название: Colorectal Cancer Screening
ISBN: 1493923323 ISBN-13(EAN): 9781493923328
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This volume provides a comprehensive overview of quality metrics and methods used to improve quality for all major modalities of CRC screening.

Treatment of Hepatic Metastases of Colorectal Cancer

Автор: P. Balladur; A. Marston; W. Stuart; Bernard Nordli
Название: Treatment of Hepatic Metastases of Colorectal Cancer
ISBN: 3642518753 ISBN-13(EAN): 9783642518751
Издательство: Springer
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Цена: 13974.00 р.
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Описание: These advances notably stem from both the work on the segmental anatomy of the liver by Couinaud [1] and that of Ton That Tung [3], which have opened the way to a simplified and segmental method of hepa- tic resection that is both safe and reliable.

Colorectal Cancer

Автор: Maurizio Ponz de Leon
Название: Colorectal Cancer
ISBN: 3642627625 ISBN-13(EAN): 9783642627620
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Colorectal cancer is one of the most frequent human tumors. This volume provides an updated and comprehensive description of the most relevant features of colorectal cancer - from molecular biology to prevention, from hereditary syndromes to new treatment modalities.

Colorectal Cancer in the Elderly

Автор: Kok-Yang Tan
Название: Colorectal Cancer in the Elderly
ISBN: 3642448097 ISBN-13(EAN): 9783642448096
Издательство: Springer
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Цена: 16769.00 р.
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Описание: As the population ages, clinicians are facing an increasing number of elderly patients with colorectal cancer. These patients pose unique challenges as they have more comorbidities and lower functional reserves. In addition, the treatment goals may differ from those in younger patients. This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.

Colorectal Cancer

Автор: Steven M. Powell
Название: Colorectal Cancer
ISBN: 1617371793 ISBN-13(EAN): 9781617371790
Издательство: Springer
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Цена: 23058.00 р.
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Описание: The contents of Colorectal Cancer: Methods and Protocols aim to instruct investigators in all the key genetic, cellular, and molecular biological methods of analyzing colorectal tumors.

Molecular Pathogenesis of Colorectal Cancer

Автор: Kevin M. Haigis, Ph.D.
Название: Molecular Pathogenesis of Colorectal Cancer
ISBN: 1461484111 ISBN-13(EAN): 9781461484110
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book identifies and characterizes targetable oncogenic pathways in colorectal cancer. It explores the current and future prospects for targeting these pathways therapeutically and presents emerging technologies for identifying new cancer related genes.

Colorectal Cancer

Автор: Jean-Fran?ois Beaulieu
Название: Colorectal Cancer
ISBN: 1493992783 ISBN-13(EAN): 9781493992782
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This volume explores the latest developments in the study of the mechanisms, diagnostics, screening methods, and therapeutics of colorectal cancer. The book’s chapters are divided into three parts: the chapters in Part One examine techniques used to study the molecular mechanisms in colorectal cancer development and progression. Part Two focuses on the innovative tools used to diagnose and detect cancer lesions in the early stages of cancer. Finally, Part Three discusses recent advancements in treating colorectal tumors and identifying new therapeutic molecules for treatment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Colorectal Cancer: Methods and Protocols is a valuable resource for any scientist and researcher interested in this field of study.

Causes and Control of Colorectal Cancer

Автор: Gabriel A. Kune
Название: Causes and Control of Colorectal Cancer
ISBN: 1461285437 ISBN-13(EAN): 9781461285434
Издательство: Springer
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Цена: 36197.00 р.
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Описание: Causes and Control of Colorectal Cancer: A Model for Cancer Prevention is a ground- breaking monograph which takes a global, multidisciplinary approach to the causes, carcinogenesis and control of colorectal cancer.

Encyclopedia of Colorectal Cancer: Volume III (Epidemiology, Psychology and Nutrition)

Автор: Young Teresa
Название: Encyclopedia of Colorectal Cancer: Volume III (Epidemiology, Psychology and Nutrition)
ISBN: 1632411369 ISBN-13(EAN): 9781632411365
Издательство: Неизвестно
Цена: 21151.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Colorectal cancer is one of the most common cancers found in many parts of the world. The challenges and mortality that this disease accompany, call for better and improved methods for patient care and treatment. This book presents the essential work that


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