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Coupling and Decoupling of Diverse Molecular Units in Glycosciences, Zbigniew J. Witczak; Roman Bielski


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Автор: Zbigniew J. Witczak; Roman Bielski
Название:  Coupling and Decoupling of Diverse Molecular Units in Glycosciences
ISBN: 9783319880624
Издательство: Springer
Классификация:



ISBN-10: 3319880624
Обложка/Формат: Soft cover
Страницы: 335
Вес: 0.54 кг.
Дата издания: 2018
Язык: English
Издание: Softcover reprint of
Иллюстрации: 140 tables, color; 81 illustrations, color; 163 illustrations, black and white; xiv, 335 p. 244 illus., 81 illus. in color.
Размер: Book (Paperback Initiative)
Читательская аудитория: Professional & vocational
Основная тема: Chemistry
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry.Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.
Дополнительное описание: Synthesis of N-linked glycopeptides using convergent enzymatic glycosylation combined with SPPS.- Synthetic Antitumor Vaccines through Coupling of Mucin Glycopeptide Antigens to Proteins.- Recent Advances in the Stereochemical Outcome of Multi Component R



Dynamic Decoupling of Robot Manipulators

Автор: Vigen Arakelian
Название: Dynamic Decoupling of Robot Manipulators
ISBN: 3030089738 ISBN-13(EAN): 9783030089733
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This book presents the latest results in the field of dynamic decoupling of robot manipulators obtained in France, Russia, China and Austria.Manipulator dynamics can be highly coupled and nonlinear. The complicated dynamics result from varying inertia, interactions between the different joints, and nonlinear forces such as Coriolis and centrifugal forces. The dynamic decoupling of robot manipulators allows one to obtain a linear system, i.e. single-input and single output system with constant parameters. This simplifies the optimal control and accumulation of energy in manipulators. There are two ways to create the dynamically decoupled manipulators: via optimal mechanical design or control.This work emphasises mechatronic solutions. These will certainly improve the known design concepts permitting the dynamic decoupling of serial manipulators with a relatively small increase in total mass of the moving links taking into account the changing payload. For the first time such an approach has been applied on serial manipulators. Also of great interest is the dynamic decoupling control of parallel manipulators. Firstly, the dynamic model of redundant multi-axial vibration table with load has been established, and, secondly, its dynamic coupling characteristics have been analyzed. The discussed methods and applications of dynamic decoupling of robot manipulators are illustrated via CAD simulations and experimental tests.

Discrete-continuum Coupling Method to Simulate Highly Dynamic Multi-scale Problems - Simulation of Laser-induced Damage in Silica Glass

Автор: Jebahi
Название: Discrete-continuum Coupling Method to Simulate Highly Dynamic Multi-scale Problems - Simulation of Laser-induced Damage in Silica Glass
ISBN: 1848217714 ISBN-13(EAN): 9781848217713
Издательство: Wiley
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Цена: 22010.00 р.
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Описание: "Discrete element and stimulation of continuous materials behavior set"--Cover.

Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Автор: Zbigniew J. Witczak; Roman Bielski
Название: Coupling and Decoupling of Diverse Molecular Units in Glycosciences
ISBN: 3319655868 ISBN-13(EAN): 9783319655864
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Synthesis of N-linked glycopeptides using convergent enzymatic glycosylation combined with SPPS.- Synthetic Antitumor Vaccines through Coupling of Mucin Glycopeptide Antigens to Proteins.- Recent Advances in the Stereochemical Outcome of Multi Component Reactions Involving Convertible Isocyanides.- Glycoconjugate-based inhibitors of Mycobacterium tuberculosis GlgE.- Selective Transformations of the Anomeric Centre in Water Using DMC and Derivatives.- [3,3]-Sigmatropic Rearrangement as a Powerful Synthetic Tool on Skeletal Modification of Unsaturated Sugars.- Recognition of thiols in coupling reactions to organic and carbohydrate acceptors.- Chemical approaches toward neurodegenerative disease prevention: the role of coupling sugars to phenolic biomolecular entities.- Probing for Trypanosoma cruzi cell surface glycobiomarkers for the diagnosis and follow-up of chemotherapy of Chagas disease.- Syntheses and Functions Glycosaminoglycan Mimicking Polymers.- Methods for the high resolution analysis of glycoconjugates.- Masking Strategies for the Bioorthogonal Release of Anticancer Glycosides.- Example of Sacrificial Unit Using Two Different Click Reactions in Coupling and Decoupling (CAD) Chemistry.- Increased efficacy of NKT cell adjuvanted peptide vaccines through chemical conjugation.

Dynamic Decoupling of Robot Manipulators

Автор: Arakelian
Название: Dynamic Decoupling of Robot Manipulators
ISBN: 3319743627 ISBN-13(EAN): 9783319743622
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This book presents the latest results in the field of dynamic decoupling of robot manipulators obtained in France, Russia, China and Austria. Manipulator dynamics can be highly coupled and nonlinear.

Advances in computational coupling and contact mechanics

Название: Advances in computational coupling and contact mechanics
ISBN: 1786344777 ISBN-13(EAN): 9781786344779
Издательство: World Scientific Publishing
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Цена: 22176.00 р.
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Описание:

This book presents recent advances in the field of computational coupling and contact mechanics with particular emphasis on numerical formulations and methodologies necessary to solve advanced engineering applications.

Featuring contributions from leading experts and active researchers in these fields who provide a detailed overview of different modern numerical schemes that can be considered by main numerical methodologies to simulate interaction problems in continuum mechanics.

A number of topics are addressed, including formulations based on the finite element method (FEM) and their variants (e.g. isogeometric analysis or standard and generalized high-order FEM: hp-FEM and GFEM, respectively), the boundary element method (BEM), the material point method (MPM) or the recently proposed finite block method (FBM), among many more.

Written with PhD students in mind, Advances in Computational Coupling and Contact Mechanics also includes the most recent numerical techniques which could be served as reference material for researchers and practicing engineers. All chapters are self-contained and can be read independently, with numerical formulations accompanied by practical engineering applications.

Silane Coupling Agents

Автор: E.P. Plueddemann
Название: Silane Coupling Agents
ISBN: 1489920722 ISBN-13(EAN): 9781489920720
Издательство: Springer
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Цена: 27950.00 р.
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Описание: Equilibrium constants for bond reten- tion are so favorable that a silane coupling agent on silica has a thousandfold advantage for bond retention in the presence of water over an alkoxysilane bond formed from hydroxy-functional polymers and silica.

Sub-structure Coupling for Dynamic Analysis

Автор: Hector Jensen; Costas Papadimitriou
Название: Sub-structure Coupling for Dynamic Analysis
ISBN: 3030128180 ISBN-13(EAN): 9783030128180
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book combines a model reduction technique with an efficient parametrization scheme for the purpose of solving a class of complex and computationally expensive simulation-based problems involving finite element models. These problems, which have a wide range of important applications in several engineering fields, include reliability analysis, structural dynamic simulation, sensitivity analysis, reliability-based design optimization, Bayesian model validation, uncertainty quantification and propagation, etc. The solution of this type of problems requires a large number of dynamic re-analyses. To cope with this difficulty, a model reduction technique known as substructure coupling for dynamic analysis is considered. While the use of reduced order models alleviates part of the computational effort, their repetitive generation during the simulation processes can be computational expensive due to the substantial computational overhead that arises at the substructure level. In this regard, an efficient finite element model parametrization scheme is considered. When the division of the structural model is guided by such a parametrization scheme, the generation of a small number of reduced order models is sufficient to run the large number of dynamic re-analyses. Thus, a drastic reduction in computational effort is achieved without compromising the accuracy of the results. The capabilities of the developed procedures are demonstrated in a number of simulation-based problems involving uncertainty.

Parasitic Substrate Coupling in High Voltage Integrated Circuits: Minority and Majority Carriers Propagation in Semiconductor Substrate

Автор: Buccella Pietro, Stefanucci Camillo, Kayal Maher
Название: Parasitic Substrate Coupling in High Voltage Integrated Circuits: Minority and Majority Carriers Propagation in Semiconductor Substrate
ISBN: 3030089762 ISBN-13(EAN): 9783030089764
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This book introduces a new approach to model and predict substrate parasitic failures in integrated circuits with standard circuit design tools.The injection of majority and minority carriers in the substrate is a recurring problem in smart power ICs containing high voltage, high current switching devices besides sensitive control, protection and signal processing circuits.The injection of parasitic charges leads to the activation of substrate bipolar transistors. This book explores how these events can be evaluated for a wide range of circuit topologies. To this purpose, new generalized devices implemented in Verilog-A are used to model the substrate with standard circuit simulators. This approach was able to predict for the first time the activation of a latch-up in real circuits through post-layout SPICE simulation analysis.


Discusses substrate modeling and circuit-level simulation of parasitic bipolar device coupling effects in integrated circuits;
Includes circuit back-annotation of the parasitic lateral n-p-n and vertical p-n-p bipolar transistors in the substrate;
Uses Spice for simulation and characterization of parasitic bipolar transistors, latch-up of the parasitic p-n-p-n structure, and electrostatic discharge (ESD) protection devices;
Offers design guidelines to reduce couplings by adding specific protections.

Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

Автор: George B. Frank; C. Paul Bianchi; Henk Keurs
Название: Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle
ISBN: 1461364833 ISBN-13(EAN): 9781461364832
Издательство: Springer
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Цена: 27950.00 р.
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Описание: The Third International Symposium on Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle, organized by George Frank, C. Cross fertilization of concepts of excitation-contraction coupling in these three types of muscle has occurred since the early studies in the late fifties and early sixties on skeletal muscle.

Coupling of Fluids, Structures and Waves in Aeronautics

Автор: Noel G. Barton; Jacques Periaux
Название: Coupling of Fluids, Structures and Waves in Aeronautics
ISBN: 3642072941 ISBN-13(EAN): 9783642072949
Издательство: Springer
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Цена: 47377.00 р.
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Описание: This Volume contains the Proceedings of a French - Australian workshop held in Melbourne, Australia from 3-6 December 2001. Entitled "Coupling of Fluids, Structures and Waves in Aeronautics (CFSWA)," the workshop was principally organised by CSIRO Mathematical and Information Sciences, Dassault Aviation and CNRS. The main purpose was to explore new computational methods and tools for efficient multi-disciplinary design in aero- nautics. This enterprise strongly depends on modelling of coupled disciplines and development of associated multi-disciplinary simulation tools. As an example of the requirements, the original logo for the workshop illustrated coupled aeroelas- ticity, scattered radar waves and high lift problems. Optimisation is required with respect to mUltiple objectives under conflict. Among the many challenges to be addressed are mathematical, numerical and en- gineering problems involving coupled flows, structures and waves. Future prog- ress on these topics strongly depends on the physical and mathematical modelling of coupled disciplines and the development of associated multi-disciplinary simu- lation tools. Strong couplings require appropriate exchanges of different kinds of information: physical and geometrical description of models, coupling of Partial Differential Equations (PDEs) at interfaces, and specification of boundary condi- tions or multi-objective functions in optimisation or control problems. Validation of multi-physics software also requires ever more efficient and accurate graphic visualisation tools representing experimental and computational data stored in da- tabases.

Transition Metal Catalyzed Oxidative Cross-Coupling Reactions

Автор: Aiwen Lei
Название: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions
ISBN: 3662581027 ISBN-13(EAN): 9783662581025
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This book is a comprehensive text covering the research and development trends in the booming field of transition metal catalyzed oxidative cross-coupling reactions. Oxidative cross-coupling reaction is a new method to forming chemical bonds besides the traditional cross-coupling reactions. This book provides the answers to how this coupling reaction occurs and what its advantages are. The palladium, copper and iron catalyzed oxidative cross-coupling reactions as the main focuses of interest are described in detail. The oxidative cross-coupling reactions catalyzed by other metals and transition-metal-free oxidative coupling reactions are also introduced.This book provides a useful reference source for researchers and graduates in the field of transition metal catalyzed coupling reactions. It is also valuable to researchers working in pharmaceutical companies, fine organic chemical companies, and etc.

Aromatic c(sp2) h dehydrogenative coupling reactions

Автор: Eftekhari-sis, Bagher
Название: Aromatic c(sp2) h dehydrogenative coupling reactions
ISBN: 0367347296 ISBN-13(EAN): 9780367347291
Издательство: Taylor&Francis
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Цена: 27562.00 р.
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Описание: A unique volume covering all types of heterocycles synthesized via aromatic C H dehydrogenative coupling reactions. The book will appeal to research groups around the world working on organic synthesis, heterocyclic compounds, catalysts, and medicinal chemistry.


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