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Fluorescent Tools for Imaging Oxidative Stress in Biology, Amandeep Kaur


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Автор: Amandeep Kaur
Название:  Fluorescent Tools for Imaging Oxidative Stress in Biology
ISBN: 9783030103712
Издательство: Springer
Классификация:




ISBN-10: 3030103714
Обложка/Формат: Soft cover
Страницы: 230
Вес: 0.43 кг.
Дата издания: 2018
Серия: Springer Theses
Язык: English
Издание: Softcover reprint of
Иллюстрации: 86 tables, color; 100 illustrations, color; 61 illustrations, black and white; xlv, 230 p. 161 illus., 100 illus. in color.
Размер: 234 x 156 x 15
Читательская аудитория: General (us: trade)
Основная тема: Chemistry
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This thesis advances the long-standing challenge of measuring oxidative stress and deciphering its underlying mechanisms, and also outlines the advantages and limitations of existing design strategies. It presents a range of approaches for the chemical synthesis of fluorescent probes that detect reversible changes in cellular oxidative stress. The ability to visualise cellular processes in real-time is crucial to understanding disease development and streamline treatment, and this can be achieved using fluorescent tools that can sense reversible disturbances in cellular environments during pathogenesis. The perturbations in cellular redox state are of particular current interest in medical research, since oxidative stress is implicated in the pathogenesis of a number of diseases.The book investigates different strategies used to achieve ratiometric fluorescence output of the reversible redox probes, which nullify concentration effects associated with intensity-based probes. It also describes suitable approaches to target these probes to specific cellular organelles, thereby enabling medical researchers to visualise sub-cellular oxidative stress levels, and addressing the typically poor uptake of chemical tools into biological studies. In total it reports on four new probes that are now being used by over twenty research groups around the globe, and two of which have been commercialised. The final chapters of this thesis demonstrate successful applications of the sensors in a variety of biological systems ranging from prokaryotes to mammalian cells and whole organisms. The results described clearly indicate the immense value of collaborative, cross-disciplinary research.
Дополнительное описание: Introduction.- Flavin based redox probes.- FRET based ratiometric redox probes.- Mitochondrially-targeted ratiometric redox probes.- Nicotinamide based ratiometric probes.- In cellulo studies.- Ex vivo studies.- Non-mammalian systems.- Conclusions.- Exper



Fluorescent Tools for Imaging Oxidative Stress in Biology

Автор: Kaur
Название: Fluorescent Tools for Imaging Oxidative Stress in Biology
ISBN: 3319734040 ISBN-13(EAN): 9783319734040
Издательство: Springer
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Цена: 13974.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Introduction.- Flavin based redox probes.- FRET based ratiometric redox probes.- Mitochondrially-targeted ratiometric redox probes.- Nicotinamide based ratiometric probes.- In cellulo studies.- Ex vivo studies.- Non-mammalian systems.- Conclusions.- Experimental Methods.

Vitamin D Oxidative Stress, Immunit

Название: Vitamin D Oxidative Stress, Immunit
ISBN: 1138199443 ISBN-13(EAN): 9781138199446
Издательство: Taylor&Francis
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Цена: 10411.00 р.
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Описание:

Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging.

A state-of-the-art compilation of essential information, this book explores:

  • Vitamin D and its genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body
  • The role vitamin D plays in modulating oxidative stress--with emphasis on cancer, stress-mediated diseases, photo-protection of the skin, and energy metabolism
  • Beneficial effects of vitamin D in regulating the immune response and its importance in protecting against autoimmune, infectious, and inflammatory diseases
  • The role vitamin D plays in the regulation of the aging process--including aspects of oxidative stress, senescence, and mortality, as well as its role in protection against cardiovascular disease and nervous system disorders

This book represents an important contribution toward understanding the mechanisms by which vitamin D promotes health, increasing awareness of the importance that vitamin D plays during development, at birth, and throughout the aging process. It is a valuable reference for researchers in academia, nutrition, medicine, and industry.

Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling

Автор: Tahira Farooqui
Название: Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling
ISBN: 111800194X ISBN-13(EAN): 9781118001943
Издательство: Wiley
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Цена: 24227.00 р.
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Описание: This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy.

Systematic Exploration of Indolizine-Based Small Fluorescent Molecules

Автор: Youngjun Lee
Название: Systematic Exploration of Indolizine-Based Small Fluorescent Molecules
ISBN: 9811346607 ISBN-13(EAN): 9789811346606
Издательство: Springer
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Цена: 13974.00 р.
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Описание:

This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter.Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working under live cell conditions.Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.
Fluorescent Proteins I

Автор: Gregor Jung
Название: Fluorescent Proteins I
ISBN: 3642269710 ISBN-13(EAN): 9783642269714
Издательство: Springer
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Цена: 36570.00 р.
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Описание: Fluorescent proteins are intimately connected to research in the life sciences. The discovery of the Green Fluorescent Protein, its first, seminal application and the ingenious development of a broad palette of fluorescence proteins of other colours, was consequently recognised with the Nobel Prize for Chemistry in 2008.

Fluorescence Microscopy and Fluorescent Probes

Автор: Jan Slav?k
Название: Fluorescence Microscopy and Fluorescent Probes
ISBN: 0306460211 ISBN-13(EAN): 9780306460210
Издательство: Springer
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Цена: 19591.00 р.
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Описание: The April 1997 conference held in Prague attracted the cream of primarily European and Russian researchers (with a handful from the US, primarily from the U. of Maryland School of Medicine) to the burgeoning biological and medical applications of innovative optical technology, particularly laser con

Fluorescent Protein-Based Biosensors

Автор: Jin Zhang; Qiang Ni; Robert H Newman
Название: Fluorescent Protein-Based Biosensors
ISBN: 1493960148 ISBN-13(EAN): 9781493960149
Издательство: Springer
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Цена: 14673.00 р.
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Описание: This book features step-by-step, readily reproducible protocols used to describe several methods in which fluorescent protein-based reporters can be used to gain unique insights into the regulation of cellular signal transduction.

Green Fluorescent Protein

Автор: Barry W. Hicks
Название: Green Fluorescent Protein
ISBN: 1617372463 ISBN-13(EAN): 9781617372469
Издательство: Springer
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Цена: 20263.00 р.
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Описание: With the cloning of the green fluorescent protein (GFP) from Aequorea victoria in 1992, another valuable tool was added to the arsenal. In Green Fluorescent Proteins: Applications and Protocols examples of how GFP can be utilized in a variety of fields are presented.

Fluorescence Microscopy and Fluorescent Probes

Автор: J. Slav?k
Название: Fluorescence Microscopy and Fluorescent Probes
ISBN: 148991868X ISBN-13(EAN): 9781489918680
Издательство: Springer
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Цена: 22203.00 р.
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Описание: Fluorescence microscopy images can be easily integrated into current video and computer image processing systems. It also makes it possible to compute ratio images (ratio imaging both in excitation and in emission) or lifetime imaging.


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