Circular RNAs, Christoph Dieterich; Argyris Papantonis

Автор: Junjie Xiao
Название: Circular RNAs
ISBN: 9811346321 ISBN-13(EAN): 9789811346323
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This book provides an essential overview of the rapidly advancing field of circular RNAs – newly discovered RNAs that are generated by back-splicing precursor mRNA and perform regulatory functions in many biological processes. Although many aspects of circular RNAs’ biology and mechanisms of gene regulation remain unclear, they have been found to be abundant, evolutionally conserved, and stable in cells; further, they have numerous potential functions. The book consists of eight parts:1) An overview of circular RNAs, 2) Bioinformatics for circular RNAs, 3) Biogenesis of circular RNAs, 4) Molecular mechanisms and gene regulation of circular RNAs, 5) Circular RNAs as potential disease biomarkers, 6) Circular RNAs and human diseases, 7) Circular RNAs in Plants and in Archaea, and 8) Future prospects. Given its focus, the book will be especially useful for researchers and students in the fields of biochemistry, molecular biology, cell biology, and medicine.

Автор: Christoph Dieterich; Argyris Papantonis
Название: Circular RNAs
ISBN: 1493975617 ISBN-13(EAN): 9781493975617
Издательство: Springer
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Цена: 13275.00 р.
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Описание:

This volume provides established approaches for identifying, characterizing, and manipulating circRNAs in vitro, in vivo, and in silico. Chapters highlight the breakthroughs and the challenges in this new field of research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Circular RNAs: Methods and Protocols aims to useful and informative for further study into this vital field.

Название: Long non-coding rnas in human disease
ISBN: 3319239066 ISBN-13(EAN): 9783319239064
Издательство: Springer
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Цена: 19591.00 р.
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Описание: The role oflncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, pastretroelements integrated within the human genome, as well as the role thesepseudogene-derived lncRNAs play in cancer development are discussed in detail.

Автор: Riki Kurokawa
Название: Long Noncoding RNAs
ISBN: 4431555757 ISBN-13(EAN): 9784431555759
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.

Автор: ?rom
Название: Enhancer RNAs
ISBN: 1493940333 ISBN-13(EAN): 9781493940332
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume provides a comprehensive overview of the experimental and computational methodologies used to study the function of long non-coding RNA (ncRNAs) expressed from enhancers. Chapter detail both wet-lab and dry-lab techniques and annotating long ncRNAs and exploring transcription by assessing where transcription starts and generally how it occurs.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Enhancer RNAs: Methods and Protocols aims to ensure successful results in this rapidly developing field.

Автор: Volker A. Erdmann; Jan Barciszewski
Название: Non Coding RNAs in Plants
ISBN: 3642269990 ISBN-13(EAN): 9783642269998
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Discovered just 20 years ago, ncRNAs have been dubbed the `secret regulators` of cells. Only recently has their function in plants been investigated. In this book leading researchers relate recent discoveries about the role played by small ncRNA in plants.

Автор: ?ur?ica Ugarkovi?
Название: Long Non-Coding RNAs
ISBN: 364226655X ISBN-13(EAN): 9783642266553
Издательство: Springer
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Цена: 23508.00 р.
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Описание: Long Non-Coding RNAs provides an overview of the rapidly advancing field, and describes the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems. Readers will find a discussion of the role of ncRNAs in sex chromosome dosage compensation, and more.

Автор: Ahmad M. Khalil
Название: Molecular Biology of Long Non-coding RNAs
ISBN: 3030170853 ISBN-13(EAN): 9783030170851
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Автор: Shinichi Nakagawa; Tetsuro Hirose
Название: Nuclear Bodies and Noncoding RNAs
ISBN: 1493922521 ISBN-13(EAN): 9781493922529
Издательство: Springer
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Цена: 13275.00 р.
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Описание: This volume focuses on cytological, biochemical, and molecular biological methods to identify and examine the function of each nuclear body, with an emphasis on the analysis of long non-coding RNAs.

Автор: Gordon G. Carmichael
Название: Regulatory Non-Coding RNAs
ISBN: 1493913689 ISBN-13(EAN): 9781493913688
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression.

Автор: Bibekanand Mallick; Zhumur Ghosh
Название: Regulatory RNAs
ISBN: 3642442846 ISBN-13(EAN): 9783642442841
Издательство: Springer
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Цена: 23508.00 р.
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Описание: Regulatory RNAs are key players in a number of cellular functions and thus are vital to the development of therapeutic and molecular medicine. This comprehensive study of the topic includes theoretical and historical perspectives as well as applications.

Автор: Xia Li; Juan Xu; Yun Xiao; Shangwei Ning; Yunpeng
Название: Non-coding RNAs in Complex Diseases
ISBN: 9811307180 ISBN-13(EAN): 9789811307188
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.