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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products, Taro Noguchi


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Автор: Taro Noguchi
Название:  Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
ISBN: 9789811349171
Издательство: Springer
Классификация:

ISBN-10: 9811349177
Обложка/Формат: Soft cover
Страницы: 80
Вес: 0.16 кг.
Дата издания: 2018
Серия: Springer Theses
Язык: English
Издание: Softcover reprint of
Иллюстрации: 18 illustrations, color; 28 illustrations, black and white; xiv, 80 p. 46 illus., 18 illus. in color.
Размер: 234 x 156 x 5
Читательская аудитория: Professional & vocational
Основная тема: Chemistry
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание:
This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested o
nly natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an ?-tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.

Дополнительное описание: Introduction.- Development of a Mirror-image Screening Process by Using Synthetic Proteins.- Synthesis of Grb2 SH2 Domain Proteins for Mirror-image Screening Systems.- Conclusions.



Plant-Based Natural Products: Derivatives and Applications

Автор: Shahid Ul-Islam
Название: Plant-Based Natural Products: Derivatives and Applications
ISBN: 111942383X ISBN-13(EAN): 9781119423836
Издательство: Wiley
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Цена: 26762.00 р.
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Описание:

The book deals with novel applications of plant derived natural agents and their derivatives in the food, textile dyeing, medicinal, and environmental areas.

Plant based natural products and their derivatives have strong influence on our everyday lives. They are needed for many everyday applications ranging from food, medicine, agriculture, textiles, and healthcare. This new book presents significant research advances about the use of plant-based natural products, mainly dyes and pigments, bioactive compounds and other plant extracts in the textile coloration, food, medicine, bioremediation and environmental applications. The topics of the ten informative chapters in Plant-Based Natural Products include the following: potential resurgence of natural dyes in applied fields; natural colorants from indigoid rich plants; phytochemical and pharmacological aspects of Butea monosperma plant; irradiation as novel pretreatment methods to improve wash fastness properties of plant derived natural dyes; dyeing studies with colorants extracted from the Lawsonia inermis plant; effect of drumstick leaf powder incorporation on quality of khakhra; physico-chemical properties of pineapple pomace powder and its incorporation in buffalo meat products; synthesis of curcumin complexes for medicinal and other industrial uses and phyto-remediation of toxic arsenic from wastewaters.

Discovery and development of neuroprotective agents from natural products

Название: Discovery and development of neuroprotective agents from natural products
ISBN: 0128095938 ISBN-13(EAN): 9780128095935
Издательство: Elsevier Science
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Цена: 26949.00 р.
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Описание:

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases.

Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer's disease, Parkinson's disease and ischemic brain stroke, are discussed.

Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs.


  • Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery
  • Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases
  • Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab
Antisense-Based Drugs and Therapeutics: Preclinica l and Clinical Considerations for Development

Автор: Ferrari
Название: Antisense-Based Drugs and Therapeutics: Preclinica l and Clinical Considerations for Development
ISBN: 1118537335 ISBN-13(EAN): 9781118537336
Издательство: Wiley
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Цена: 28346.00 р.
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Описание: Antisense-based drugs are part of a growing number of pharmaceutical and biotech programs to treat diseases including cancer, diabetes, and ALS. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide from the safety assessment to clinical experience with antisense oligonucleotides.

Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Автор: J.L. Ingham; A. Koskinen; M. Lounasmaa
Название: Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products
ISBN: 3709187052 ISBN-13(EAN): 9783709187050
Издательство: Springer
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Цена: 12157.00 р.
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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progr?s dans la Chimie des Substances Organiques Naturelles

Автор: A. Albert; K. Br?ckner; R.B. Corey; K. Freudenberg
Название: Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progr?s dans la Chimie des Substances Organiques Naturelles
ISBN: 3709180163 ISBN-13(EAN): 9783709180167
Издательство: Springer
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Цена: 12157.00 р.
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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progr?s dans la Chimie des Substances Organiques Naturelles

Автор: J. Engel; W. Grassmann; K. Hannig; H. H?rmann; L.M
Название: Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progr?s dans la Chimie des Substances Organiques Naturelles
ISBN: 3709171415 ISBN-13(EAN): 9783709171417
Издательство: Springer
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Цена: 12157.00 р.
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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progr?s dans la Chimie des Substances Organiques Naturelles

Автор: P.H. Abelson; H. Barkemeyer; K. Bernauer; A.E. Dim
Название: Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products / Progr?s dans la Chimie des Substances Organiques Naturelles
ISBN: 3709180546 ISBN-13(EAN): 9783709180549
Издательство: Springer
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Цена: 12157.00 р.
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Cosmetic Creams: Development and Formulation of Effective Skin Care Products

Автор: Wilfried R?hse
Название: Cosmetic Creams: Development and Formulation of Effective Skin Care Products
ISBN: 3527343989 ISBN-13(EAN): 9783527343980
Издательство: Wiley
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Цена: 22168.00 р.
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Описание: A guide to cosmetic creams that focuses on formulation, production, and safety concerns

Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products puts the focus on the structure and formulation of a cosmetic cream, the production process, the effect of each ingredient, as well as safety considerations. Comprehensive in scope, the book contains a basic definition of cosmetics and describes the types of skin creams currently on the market, the major ingredients used, and example compositions. The author, Wilfried R?hse?a noted expert on the topic?offers guidelines for estimating manufacturing costs and includes procedures for an effective safety assessment.

The book contains information on various aspects of skin penetration and production and covers issues like materials used and hygienic packaging. In addition, R?hse reviews legal regulations with an emphasis on the European market. He discusses GMP and EHEDG directives. This important book:

-Offers a comprehensive resource that explores all aspects of cosmetic cream manufacturing and marketing
-Provides valuable guidelines for practitioners in the field
-Covers the underlying technologies of cosmetic creams
-Includes a review of raw material and manufacturing costs, hygiene and safety, and legal regulations
-Written by an author with more than 30 years? experience in the industry

Written for cosmetic chemists, chemists in industry, chemical engineers, dermatologists, Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products, offers a unique industrial perspective of the topic that is comprehensive in scope.

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

Автор: Brahmachari, Goutam
Название: Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases
ISBN: 0128157232 ISBN-13(EAN): 9780128157237
Издательство: Elsevier Science
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Цена: 28970.00 р.
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Описание:

Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more.

In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases.

  • Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery
  • Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases
  • Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases
Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Автор: Y. Asakawa; M. Heidelberger
Название: Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products
ISBN: 370918679X ISBN-13(EAN): 9783709186794
Издательство: Springer
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Цена: 12157.00 р.
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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Автор: J.W. Daly; D. Ferreira; S.J. Gould; E. Haslam; D.J
Название: Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products
ISBN: 3709186587 ISBN-13(EAN): 9783709186589
Издательство: Springer
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Цена: 12157.00 р.
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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Автор: R.C. Anderson; Bertram Fraser-Reid; H. Jones; T. K
Название: Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products
ISBN: 370918553X ISBN-13(EAN): 9783709185537
Издательство: Springer
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Цена: 12157.00 р.
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