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RNA Metabolism in Neurodegenerative Diseases, Rita Sattler; Christopher J. Donnelly


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Цена: 13974.00р.
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Автор: Rita Sattler; Christopher J. Donnelly
Название:  RNA Metabolism in Neurodegenerative Diseases
ISBN: 9783030078324
Издательство: Springer
Классификация:


ISBN-10: 3030078329
Обложка/Формат: Soft cover
Страницы: 310
Вес: 0.51 кг.
Дата издания: 2018
Серия: Advances in Neurobiology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 34 illustrations, color; xx, 310 p. 34 illus. in color.
Размер: 234 x 156 x 18
Читательская аудитория: General (us: trade)
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--?mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--? coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--?directional transcription and production of repeat associated non--?ATG (RAN) translation products.This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
Дополнительное описание: RNA Metabolism in Neurodegenerative Diseases.- Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes.- RNA Editing Deficiency in Neurodegeneration.- RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases.- RNA Degradation in Neu



Environmental Factors in Neurodegenerative Diseases

Автор: Aschner, Michael
Название: Environmental Factors in Neurodegenerative Diseases
ISBN: 0128127643 ISBN-13(EAN): 9780128127643
Издательство: Elsevier Science
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Цена: 25265.00 р.
Наличие на складе: Поставка под заказ.

Описание:

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Edited by leading subject experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. As a result, this serial is an essential and unique resource for researchers and graduate students alike.


  • Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology
  • Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers
  • Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America
  • Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government
RNA Metabolism in Neurodegenerative Diseases

Автор: Sattler
Название: RNA Metabolism in Neurodegenerative Diseases
ISBN: 3319896881 ISBN-13(EAN): 9783319896885
Издательство: Springer
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Цена: 13974.00 р.
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Nanobiotechnology in Neurodegenerative Diseases

Автор: Mahendra Rai; Alka Yadav
Название: Nanobiotechnology in Neurodegenerative Diseases
ISBN: 3030309290 ISBN-13(EAN): 9783030309299
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.

Biometals in Neurodegenerative Diseases

Автор: White, Anthony R.
Название: Biometals in Neurodegenerative Diseases
ISBN: 0128045620 ISBN-13(EAN): 9780128045626
Издательство: Elsevier Science
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Цена: 19875.00 р.
Наличие на складе: Поставка под заказ.

Описание:

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.

This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.

Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.

  • Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets
  • Written for academic researchers, clinicians, and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology
  • Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases
Neurodegenerative Diseases

Автор: Philip Beart; Michael Robinson; Marcus Rattray; Ni
Название: Neurodegenerative Diseases
ISBN: 3319571915 ISBN-13(EAN): 9783319571911
Издательство: Springer
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Цена: 32142.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies.

Neurodegenerative diseases

Название: Neurodegenerative diseases
ISBN: 3030102890 ISBN-13(EAN): 9783030102890
Издательство: Springer
Рейтинг:
Цена: 16769.00 р.
Наличие на складе: Поставка под заказ.

Описание: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer`s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson`s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases.

The Benefits of Natural Products for Neurodegenerative Diseases

Автор: Essa
Название: The Benefits of Natural Products for Neurodegenerative Diseases
ISBN: 3319283812 ISBN-13(EAN): 9783319283814
Издательство: Springer
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Цена: 25155.00 р.
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Описание: Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Neuroglia in Neurodegenerative Diseases

Автор: Verkhratsky
Название: Neuroglia in Neurodegenerative Diseases
ISBN: 9811399123 ISBN-13(EAN): 9789811399121
Издательство: Springer
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Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Disease-Modifying Targets in Neurodegenerative Disorders

Автор: Baekelandt, Veerle
Название: Disease-Modifying Targets in Neurodegenerative Disorders
ISBN: 0128051205 ISBN-13(EAN): 9780128051207
Издательство: Elsevier Science
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Цена: 11706.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.

This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.

  • Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
  • Summarizes how patients are treated today, providing a glance at future disease management
  • Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
  • Written and peer reviewed by outstanding scientists in their respective fields
Protein Quality Control in Neurodegenerative Diseases

Автор: Richard I. Morimoto; Yves Christen
Название: Protein Quality Control in Neurodegenerative Diseases
ISBN: 3642447066 ISBN-13(EAN): 9783642447068
Издательство: Springer
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Цена: 19589.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer`s disease, Parkinson`s disease, amyotrophic lateral sclerosis, Huntington`s disease, and other diseases of protein conformation.

Neurodegenerative Diseases

Автор: Daniela Galimberti; Elio Scarpini
Название: Neurodegenerative Diseases
ISBN: 1447172426 ISBN-13(EAN): 9781447172420
Издательство: Springer
Рейтинг:
Цена: 16769.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer`s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases.

Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Автор: Alexzander A.A. Asea; Ian R. Brown
Название: Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
ISBN: 9048178134 ISBN-13(EAN): 9789048178131
Издательство: Springer
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Цена: 32004.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book reviews current progress on heat shock proteins in the brain and their implications for neurodegenerative diseases, neuroprotection, aging and control of life span. It features contributions from laboratories from major universities around the world.


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