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The Science and Regulations of Naturally Derived Complex Drugs, Ram Sasisekharan; Sau L. Lee; Amy Rosenberg; Larry


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Цена: 20962.00р.
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Автор: Ram Sasisekharan; Sau L. Lee; Amy Rosenberg; Larry
Название:  The Science and Regulations of Naturally Derived Complex Drugs
ISBN: 9783030117504
Издательство: Springer
Классификация:

ISBN-10: 3030117502
Обложка/Формат: Hardcover
Страницы: 331
Вес: 0.68 кг.
Дата издания: 2019
Серия: AAPS Advances in the Pharmaceutical Sciences Series
Язык: English
Издание: 1st ed. 2019
Иллюстрации: 35 tables, color; 41 illustrations, color; 20 illustrations, black and white; vi, 331 p. 61 illus., 41 illus. in color.
Размер: 234 x 156 x 21
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This volume in the AAPS Advances series covers various quality, safety and clinical aspects of drug development that are relevant to new and/or generic drugs containing a complex mixture of molecules. Specific topics discussed include: raw materials sourcing; manufacturing controls; characterization; identification of critical product quality components and attributes; identification of impurities, particularly as they bear on toxicity and immunogenicity; clinical trial study design considerations, and the regulatory science applications to development of such complex mixtures. Complex mixtures are challenging to characterize and analyze using standard methods. Further challenges extend throughout the product development cycle from raw material control to clinical study design. The regulatory landscape is rapidly changing as new types of complex mixtures are introduced into clinical trials and to the market (e.g., traditional Chinese medicines and medical marijuana products), while older products are facing generic competition for the first time (e.g., enoxaparin). The future outlook for complex generic drug products, as opposed to the more commonly developed targeted single agent drug products is not clear. The risks pertaining to lack of a full understanding of raw material control, process and controls in manufacture, as well as characterization of a complex mixture were seen vividly during the heparin crisis of 2008. As such powerful lessons have been learned about the regulatory science specific to complex products. The Science and Regulations of Naturally Derived Complex Drugs addresses the interests among industry, academics, and government on the issues surrounding the future development of mixtures for medicinal use.
Дополнительное описание: Evolving Challenges in Developing Naturally-Derived Complex Mixtures into Drugs: U.S. Experience and Perspective.- Regulatory Landscapes for Approval of Naturally-derived Complex Mixture Drugs.- Complex Natural Product Heparin: Biosynthesis, Biology and A



Advances in Polymer Derived Ceramics and Composites - Ceramic Transactions V213

Автор: Colombo
Название: Advances in Polymer Derived Ceramics and Composites - Ceramic Transactions V213
ISBN: 0470878002 ISBN-13(EAN): 9780470878002
Издательство: Wiley
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Цена: 16782.00 р.
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Описание: This book collects some of papers presented at the very successful Symposium "Polymer Derived Ceramics and Composites" in the framework of the 8th Pacific Rim Conference on Ceramic and Glass Technology. There, over 70 researchers from around the world discussed their latest innovations over four full days.

Derived Embodiment in Abstract Language

Автор: Theresa Schilhab
Название: Derived Embodiment in Abstract Language
ISBN: 3319560557 ISBN-13(EAN): 9783319560557
Издательство: Springer
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Цена: 13974.00 р.
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Описание:

How does knowledge of phenomena and events we have no direct experiences of emerge? Having a brain that learns from being in the world, how can we conceive of prehistoric dinosaurs, Atlantis, unicorns or even 'desire'? This book is about how abstract knowledge becomes anchored in direct experiences through well-formed conversations.

Within the framework of evolutionary biology and through the lens of contemporary studies in cognitive science, the neurosciences, sociology and anthropology, this book traces topics such as our inborn sensitivity to the environment, bottom-up and top-down processes in knowledge formation and the importance of language when we learn to categorise the world.

A major objective of this monograph is to identify the key determinants of the specific interactivity mechanisms that control the cognitive processes while we are linguistically immersed. The emphasis is on real-life interactions in conversations. While the concrete word-object paradigm depends relatively more on direct experiences, the successful acquisition of abstract knowledge depends on the emphatic skills of the interlocutor. He or she must remain sensitive to the level and quality of the imagination of the child while making mental tableaus that are believed to elicit images to which the child associates the concept.

Derived embodiment in abstract thought is a landmark synthesis that operationalizes contemporary neuroscience studies of acquisition of knowledge in the real life conversational context. The result is an exciting biology-based contribution to theories of knowledge acquisition and thinking in sociology, cognitive robotics, anthropology and not at least, pedagogy.

Plasticizers Derived from Post-consumer PET

Автор: Langer, Ewa
Название: Plasticizers Derived from Post-consumer PET
ISBN: 0323462006 ISBN-13(EAN): 9780323462006
Издательство: Elsevier Science
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Цена: 26949.00 р.
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Описание:

Plasticizers Derived from Postconsumer PET: Research Trends and Potential Applications presents a roadmap to the successful use of postconsumer PET to obtain plasticizers for later use, a proposal which presents both economic and sustainability advantages. Based on the results of the latest research into the development of chemical recycling techniques of PET waste, this book describes techniques where the plasticizer obtained can be utilized for value addition in PVC and other polymers.

In addition, the book provides basic introductory information on the role of plasticizers in the modification of polymers, basic quality requirements, and the latest trends in the synthesis and use of plasticizers in industry, also presenting the available methods of PET recycling, with particular emphasis on chemical recycling, analysis of the PET market, the availability of postconsumer PET, and its value as a raw material for other products.

Based on the authors' research, the book discusses the use of postconsumer PET in the synthesis of monomeric and oligomeric plasticizers. Synthesis conditions are shown in detail, and the influence of the structure of synthesized softeners on their basic quality parameters are assessed and compared with selected commercially available products. In the final sections, the book covers the economic challenges and benefits of this process and its application to newly developed products.

  • Presents a step-by-step introduction to the methods of recycling PET into usable plasticizers
  • Provides a viable, actionable alternative to landfills for postconsumer PET, enabling the recycling of more waste polymer and reducing the carbon footprint of PET
  • Analyzes the economic benefits and challenges of this process
  • Compares the quality of the output to commercially available products
Surface Activity of Petroleum Derived Lubricants

Автор: Pillon, Lilianna Z.
Название: Surface Activity of Petroleum Derived Lubricants
ISBN: 1138374091 ISBN-13(EAN): 9781138374096
Издательство: Taylor&Francis
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Цена: 9798.00 р.
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Описание:

Hundreds of lubricant additives are available industry-wide to improve base stock properties and protect metal surfaces; however, the wrong combination of these commodities can result in substandard performance. Surface Activity of Petroleum Derived Lubricants explains how surface activity is affected by several factors: the interfacial properties of lube oil base stocks at oil/surface interfaces, lubricant solvency properties, additive interactions, and variations in temperature. The book provides an understanding of these factors that will influence proper selection of base stocks and additives necessary for resisting foaming and air entrainment, inhibiting rust and corrosion, preventing wear, and controlling emulsification and demulsification.

Using 300 tables to provide experimental data from books, journals, and the patent literature, this practical and comprehensive reference examines:

  • the refining of lube oil base stocks
  • the chemistry of additives
  • the formulation technology of lubricants
  • the performance of the most important finished products such as turbine oils, hydraulic fluids, and engine oils

Insight into these variables enables petroleum chemists and engineers to choose the right lubricant base stock and additive combination. By becoming aware of these important elements, those in industry are better able to make the right choices, leading to reduced costs, improved performance, and better management of production timelines.

Brain-Derived Neurotrophic Factor (BDNF)

Автор: Carlos B. Duarte; Enrico Tongiorgi
Название: Brain-Derived Neurotrophic Factor (BDNF)
ISBN: 1493989693 ISBN-13(EAN): 9781493989690
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This volume discusses the latest techniques and methodologies used in the neurotrophin field to study the physiology of the Brain-Derived Neurotrophic Factor (BDNF). The book provides the tools essential to any researcher that intends to explore the peculiar regulation of this neurotrophin from gene expression to its release and the signaling by TrkB receptors, as well as to study the neuronal responses to BDNF or the role of neurotrophin in various neurological diseases. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting edge and comprehensive, Brain-Derived Neurotrophic Factor(BDNF) is a valuable resource for researchers who want to further study the diversity of physiological roles of this important growth factor.

Lipid Hydroperoxide-Derived Modification of Biomolecules

Автор: Yoji Kato
Название: Lipid Hydroperoxide-Derived Modification of Biomolecules
ISBN: 9402402969 ISBN-13(EAN): 9789402402964
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Lipid peroxidation is an important cellular process which can lead to detrimental effects if it is not regulated efficiently. Lipid hydroperoxide is formed in an initial step of lipid peroxidation. Lipid hydroperoxide is also known as a potential source of singlet oxygen. Harmful aldehydes are formed when the lipid hydroperoxide is degraded. The formed aldehyde has high reactivity against thiol or amine moieties. Therefore, it could act as a signaling molecule, which might induce the changing of gears inside a cell. Recent studies have shown that lipid hydroperoxide or a slightly modified product of the lipid hydroperoxide reacts with biomolecules such as proteins and aminophospholipids, which leads to formation of amide-type adducts. Amide-type adducts could be one of markers for oxidative stress and could also be an important player in some diseases. In this book, the chemistry and biochemistry of lipid hydroperoxide along with their conjugates with biomolecules are described.

Regenerative Therapy Using Blood-Derived Stem Cells

Автор: David S. Allan; Dirk Strunk
Название: Regenerative Therapy Using Blood-Derived Stem Cells
ISBN: 162703885X ISBN-13(EAN): 9781627038850
Издательство: Springer
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Цена: 23508.00 р.
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Описание: Some of these cell types and various blood-derived cell lineages are involved in the repair of various types of tissue damage that span the spectrum of medical disorders.

Extracellular Matrix-derived Medical Implants in Clinical Medicin

Автор: Daniel Mooradian
Название: Extracellular Matrix-derived Medical Implants in Clinical Medicin
ISBN: 0081001665 ISBN-13(EAN): 9780081001660
Издательство: Elsevier Science
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Цена: 27454.00 р.
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Описание: "

Extracellular Matrix-Derived Implants in Clinical Medicine "comprehensively covers the emergence of tissue engineering and regenerative medicine over the past few decades, along with discussions of continuous funding and research.

The book provides a state-of-the-art review of this increasingly important technology and how it is translating from bench to bedside. Part One of the book looks at the historical use of human and animal tissues, focusing on the main application areas, including cardiovascular, hard and soft tissue engineering, and neurological, while Part Two examines the challenges in harvesting, processing, and manufacturing of extracellular matrices, with a final section reviewing the international regulatory environment and economics of tissue-based products.
Addresses issues of tissue engineering and regenerative medicine from a biomaterials industry perspectiveLooks at the historical use of human and animal tissues, focusing on the main application areas, including cardiovascular, hard and soft tissue engineering, and neurologicalExamines the challenges in harvesting, processing, and manufacturing of extracellular matricesReviews the international regulatory environment and economics of tissue-based products


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