Glutamate Receptors, Corinna Burger; Margaret Jo Velardo
Автор: Daniel Monaghan; Robert Wenthold Название: The Ionotropic Glutamate Receptors ISBN: 1461284422 ISBN-13(EAN): 9781461284420 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The field of the excitatory amino acids was born when L-glutamate and L-aspartate were found to be potent convulsants (Hayashi, 1954), and were subsequently found to excite neurons directly (Curtis, Phillis, and Watkins, 1959). Although these studies initiated the hypothesis of glutamate-mediated neurotransmission, it was noted that the ubiquitous actions of glutamate could also reflect a general, nonspecific property of glutamate on neuronal mem- branes. It was not until 20 years later that pharmacological, physiological, and biochemical studies provided convincing evidence for a neurotransmitter role for glutamate in the mammalian central nervous system (CNS). With the critical demonstration that the pharmacologically defined glutamate receptors mediate synaptic currents, glutamate rapidly became widely accepted as a majorneurotransmitter by the mid-1980s. This breakthrough, together with the simultaneous findings that glutamate receptors are involved in many essential, as well as pathological, processes in the CNS, instantly transformed the study of glutamate receptors into one of the fastest-growing and most exciting areas of neuroscience. With the cloning of numerous ionotropic glutamate receptor subunits over the last six years, the field has experienced another dramatic acceleration in the understanding of receptor action and in providing the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors.
Автор: Peter Jonas; Hannah Monyer Название: Ionotropic Glutamate Receptors in the CNS ISBN: 3540661204 ISBN-13(EAN): 9783540661207 Издательство: Springer Рейтинг: Цена: 85111.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Robert W. Gereau; Geoffrey Swanson Название: The Glutamate Receptors ISBN: 1627039201 ISBN-13(EAN): 9781627039208 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student.
Автор: P. Jeffrey Conn; Jitendra Patel Название: The Metabotropic Glutamate Receptors ISBN: 1617370061 ISBN-13(EAN): 9781617370069 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It is the goal of The Metabotropic Glutamate Receptors to provide acomprehensive and forward-thinking review ofthe tremen- dous advances that have occurred in less than a decade of metabotropic glutamate receptors (mGluR) research. Virtually every areaof mGluR research is covered, including the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of mGluRs. It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research. Glutamic acid is an amino acid that has long been known to play several important metabolic roles in central and peripheral tissues and to be a component of several naturally occurring molecules. The first evidence that glutamate mayaIso serve as a neurotransmitter in the central nervous system (CNS) came in the late 1950s and early 1960s when glutamate and other acidic amino acids were found to induce behavioral convulsions when topically applied to the cortex and to excite a wide variety of central neurons. These findings spurred a massive research effort that quickly established glutamate as the pri- mary excitatory neurotransmitter in the vertebrate CNS. One of the most striking characteristics of glutamate that was quickly recognized was its ubiquitous role in serving as the neurotransmitter at the vast majority of excitatory synapses in the brain. It is now clear that most central neuronal circuits involve glutamatergic neurotransmission at some level.
Описание: Introduction to the Glutamate-Glutamine cycle.- Glucose, lactate, β-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle.- Anaplerosis for glutamate synthesis in the neonate and in adulthood.- Enzyme complexes important for the glutamate-glutamine cycle.- BCAA metabolism and NH3 homeostasis.- Glutaminases Vesicular Glutamate Uptake.- The glutamine transporters and their role in the Glutamate/GABA-Glutamine Cycle.- Glutamine Metabolism in Gliomas.- Oligodendrocytes: development, physiology and glucose metabolism.- Dysregulation of glutamate cycling mediates methylmercury-induced neurotoxicity.- Astroglia, glutamatergic transmission and psychiatric diseases.- Glutamine Synthetase: Role in Neurological Disorders.- The Glutamate - Glutamine Cycle in Epilepsy.- Index.
The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicated in numerous neurological and psychiatric disorders. Information from the cerebral cortex and thalamus is conveyed to basal ganglia nuclei via glutamate release, while dopamine from the midbrain is released in close proximity to glutamate. At the heart of both function and dysfunction of basal ganglia circuits is the interaction of these two neurotransmitters, dopamine and glutamate.
Elucidating the relationship between their molecular and cellular effects and behavioural significance has been challenging, but in the past 5-10 years, improved labeling, imaging, recording, and genetic manipulation approaches have yielded new information on how dopamine and glutamate interact to generate the circuit activity underpinning basal ganglia function. Dopamine-Glutamate Interactions in the Basal Ganglia synthesizes this recent researchfrom the level of receptor molecules all the way to complex behaviours and disease.
Current insights from research on individual neurons and synapses, detailed circuit analysis, and learning and action functions of the basal ganglia are presented against a historical perspective. The book also discusses compromised dopamine-glutamate interaction in disorders of basal ganglia function, including Parkinson's disease, Huntington's disease, and drug addiction.
Автор: Philippe Ascher; Dennis W. Choi Название: Glutamate, Cell Death and Memory ISBN: 3642845282 ISBN-13(EAN): 9783642845284 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As for the proceedings of the meeting on Alzheimer`s disease - published in the series Research and Perspectives in Alzheimer`s disease -these meetings will be reported in a new series, distributed at an international level, Research and Perspectives in Neurosciences.
Автор: Gabriela K. Popescu Название: Ionotropic Glutamate Receptor Technologies ISBN: 1493948954 ISBN-13(EAN): 9781493948956 Издательство: Springer Рейтинг: Цена: 13275.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume explores key technologies that are used currently to investigate iGluR structure, function and physiology.
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