Multifractals and Chronic Diseases of the Central Nervous System, Dipak Ghosh; Shukla Samanta; Sayantan Chakraborty
Автор: R.A. Thompson; John R. Green Название: Infectious Diseases of the Central Nervous System ISBN: 9401163340 ISBN-13(EAN): 9789401163347 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The contents of this volume are based upon the proceedings of a Sympo- sium entitled "Infectious Diseases of the Central Nervous System" held in Phoenix, Arizona, and sponsored by the Barrow Neurological Institute and Foundation during its Ninth Annual Symposium.
Автор: Dwaine F. Emerich; Reginald L. Dean III; Paul R. S Название: Central Nervous System Diseases ISBN: 089603724X ISBN-13(EAN): 9780896037243 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A critical review of the animal models used in developing powerful new therapies for central nervous system diseases. Techniques that rely heavily on behavioural analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated.
Описание: This collection of pediatric clinical cases focus on multiple sclerosis, neuromyelitis optica, acute disseminated encephalomyelitis and mimics.
Автор: Dwaine F. Emerich; Reginald L. Dean III; Paul R. S Название: Central Nervous System Diseases ISBN: 1617371521 ISBN-13(EAN): 9781617371523 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases.
Автор: Ghiso Jorge A, Rostagno Agueda A Название: Protein Folding Disorders Of The Central Nervous System ISBN: 9813222956 ISBN-13(EAN): 9789813222953 Издательство: World Scientific Publishing Рейтинг: Цена: 22018.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements.
This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases.
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