Автор: Sergey Fedoroff; Bernhard H.J. Juurlink; J. Ronald Название: Biology and Pathology of Astrocyte-Neuron Interactions ISBN: 1475794886 ISBN-13(EAN): 9781475794885 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Second Altschul Symposium held in Saskatoon, Saskatchewan, Canada, May 20-23, 1992.
Автор: Richard Milner Название: Astrocytes ISBN: 1493958593 ISBN-13(EAN): 9781493958597 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology (TM) book is a comprehensive guide to techniques for astrocyte cell culture, and more specialized approaches for studying astrocyte functions, both in vitro and in vivo. Offers step-by-step protocols, troubleshooting tips and more.
Автор: Hubbard, Jacqueline Название: Astrocytes and Epilepsy ISBN: 0128024011 ISBN-13(EAN): 9780128024010 Издательство: Elsevier Science Рейтинг: Цена: 14654.00 р. Наличие на складе: Нет в наличии.
Описание:
Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory." Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy.
Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy.
Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume
Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions
Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Название: Astrocytes ISBN: 113837430X ISBN-13(EAN): 9781138374300 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellular connections and surveys the most current findings on astrocyte activity.
The first section of the book identifies major astrocyte biomarkers and describes how they define the different connectivity domains. Next, the book examines the role of these connections. It explains how their function can be manipulated under physiological conditions and how dysfunction of the connectivity leads to aberrant brain performance. The final section explores the alterations of glia that have been observed in specific diseases of the brain. These include epilepsy, autoimmune encephalitis, Alzheimer's disease, autism, and major depression. The book identifies key mechanisms responsible for these alterations.
An important and emerging field, astrocytes and their functions are critical to neuroscientists and neurologists, both in academia and in industry, particularly in the search for and development of new drugs to combat a variety of diseases affecting the CNS. As research continues to grow in this area, this volume will spur heightened advances and understanding into the effects of these neural cells on a range of pathologies.
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