Mitochondria in Health and in Sickness, Andrea Urbani; Mohan Babu
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Описание: The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals.
Автор: Keshav Singh; Leslie Costello Название: Mitochondria and Cancer ISBN: 1441927387 ISBN-13(EAN): 9781441927385 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer.
Автор: Jorge Cruz-Reyes; Michael W. Gray Название: RNA Metabolism in Mitochondria ISBN: 3030086372 ISBN-13(EAN): 9783030086374 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5? and 3? ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.
Автор: Justin C. St. John Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells ISBN: 1627038671 ISBN-13(EAN): 9781627038676 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.
Автор: Dejana Mokranjac; Fabiana Perocchi Название: Mitochondria ISBN: 149396822X ISBN-13(EAN): 9781493968220 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
A Guide to Computational Methods for Predicting Mitochondrial Localization.- Isolation of Functional Mitochondria from Cultured Cells and Mouse Tissues.- Isolation of Mitochondria From Saccharomyces Cerevisiae.- Isolation of Contact Sites Between Inner and Outer Mitochondrial Membranes.- Isolation Of Mitochondria-Associated Membranes (MAM) from Mouse Brain Tissue.- Label-Free Quantitative Analysis of Mitochondrial Proteomes using the Multienzyme Digestion-Filter Aided Sample Preparation (MED-FASP) and 'Total Protein Approach'.- Quantitative Analysis of Glycerophospholipids in Mitochondria by Mass Spectrometry.- Detection of Cysteine Redox States in Mitochondrial Proteins in Intact Mammalian Cells.- Chemical Crosslinking in Intact Mitochondria.- Reconstitution of Mitochondrial Membrane Proteins into Nanodiscs by Cell-Free Expression.- Detection of Dual Targeting and Dual Function of Mitochondrial Proteins in Yeast.- Localizing Mrnas Encoding Mitochondrial Proteins in Yeast by Fluorescence Microscopy and Subcellular Fractionation.- Assessing Mitochondrial Bioenergetics in Isolated Mitochondria from Various Mouse Tissues using Seahorse XF96 Analyzer.- Application of FRET-Based Biosensor "Ateam" for Visualization of ATP Levels in the Mitochondrial Matrix of Living Mammalian Cells.- A Microplate-Based Bioluminescence Assay of Mitochondrial Calcium Uptake.- New Imaging Tools to Analyze Mitochondrial Morphology in Caenorhabditis Elegans.- Single Molecule Tracking and Localization Of Mitochondrial Protein Complexes in Live Cells.- Analysis of Yeast Mitochondria by Electron Microscopy.- Analysis of Mitochondrial Membrane Protein Complexes by Electron Cryo-Tomography.- Assays for Mitophagy in Yeast.- Assessing Mitochondrial Selective Autophagy in the Nematode Caenorhabditis Elegans.- Assessing Mitochondrial Unfolded Protein Response in Mammalian Cells.- Analysis of Mitochondrial RNA-Processing Defects in Patient-Derived Tissues by Qrt-PCR and Rnaseq.- Identification of Disease-Causing Mutations by Functional Complementation of Patient-Derived Fibroblast Cell Lines.
Автор: Dario Leister; Johannes M. Herrmann Название: Mitochondria ISBN: 1627038337 ISBN-13(EAN): 9781627038331 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Mitochondria: Practical Protocols offers a broad collection of methods for studying the molecular biology, function, and features of mitochondria. In the past decade, mitochondrial research has elucidated the important influence of mitochondrial processes on integral cell processes such as apoptosis and cellular aging. This practical guide presents a wide spectrum of mitochondrial methods, each written by specialists with solid experience and intended for implementation by novice and expert researchers alike. Part I introduces major experimental model systems and discusses their specific advantages and limitations for functional analysis of mitochondria. The concise overview of general properties of mitochondrial systems is supplemented by detailed protocols for cultivation of model organisms. Parts II-VI comprise a robust collection of protocols for studying different molecular aspects of mitochondrial functions including: genetics and microbiology, biochemistry, physiology, dynamics and morphology, and functional genomics. Emphasis is placed on new and emerging topics in mitochondrial study, such as the examination of apoptotic effects, fusion and fission of mitochondria, and proteome and transcriptome analysis.
Автор: Hockenbery Название: Mitochondria and Cell Death ISBN: 1493936107 ISBN-13(EAN): 9781493936106 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material.
Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology, as well as those interested in the study of mitochondria and cell biology.
Автор: John J. Lemasters; Anna-Liisa Nieminen Название: Mitochondria in Pathogenesis ISBN: 1475786956 ISBN-13(EAN): 9781475786958 Издательство: Springer Рейтинг: Цена: 32652.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson`s, Alzheimer`s, and Lou Gehrig`s disease.
Автор: Lopez-Otin, Carlos Название: Mitochondria and Longevity ISBN: 0128157364 ISBN-13(EAN): 9780128157367 Издательство: Elsevier Science Рейтинг: Цена: 27791.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Mitochondria and Longevity, Volume 340, the latest release in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics with this release focusing on topics such as Mitochondria metabolism and aging, Mitohormesis, Mitochondrial dynamics in the aging stem cell compartment, Mitochondrial proteostasis and aging, Mitochondrial DNA mutations and aging, Mitochondrial sirtuins, NAD+, NADH and aging, Mitophagy and aging, Mitochondria, calcium transport and aging.
Описание: The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals.
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