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Beta-Arrestins, Mark G. H. Scott; St?phane A. Laporte


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Автор: Mark G. H. Scott; St?phane A. Laporte
Название:  Beta-Arrestins
ISBN: 9781493991570
Издательство: Springer
Классификация:



ISBN-10: 1493991574
Обложка/Формат: Hardcover
Страницы: 409
Вес: 1.01 кг.
Дата издания: 2019
Серия: Methods in Molecular Biology
Язык: English
Издание: 1st ed. 2019
Иллюстрации: 58 tables, color; 60 illustrations, color; 19 illustrations, black and white; xiv, 409 p. 79 illus., 60 illus. in color.
Размер: 254 x 178 x 24
Читательская аудитория: Professional & vocational
Основная тема: Life Sciences
Подзаголовок: Methods and Protocols
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This volume looks at various approaches to study the pleiotropic roles of b-arrestins (b-arrs) in the control of signal transduction, and the resulting cellular and in vivo consequences that arise. The chapters in this book cover diverse topics around b-arrs such as their established roles in GPCR regulation and trafficking; regulatory scaffolding functions of b-arrs in MAPK signaling, cAMP hydrolysis and cytoskeletal dynamics; proteomic analysis of the b-arr interactome; mathematical modelling of b-arr signaling networks; functional selectivity involving biased ligands; nucleocytoplasmic trafficking and primary cilia-associated functions of b-arrs; conformational plasticity of b-arrs; and the roles of b-arrs in allergic inflammation, Type 2 Diabetes, Parkinson’s disease, and cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and authoritative, Beta-Arrestins: Methods and Protocols is a valuable resource for researchers interested in learning more about the function and regulation of b-arrestins.

Дополнительное описание: A Brief History of the b-Arrestins.- b-Arrestins: Multitask Scaffolds Orchestrating the Where and When In Cell Signaling.- Methods to Monitor the Trafficking of ?-Arrestin/G Protein-Coupled Receptor Complexes using Enhanced Bystander BRET.- Methods to Inv



Metabolic Control in Diabetes Mellitus Beta Adrenoceptor Blocking Drugs NMR Analysis of Cancer Cells Immunoassay in the Clinical Laboratory Cyclosporine

Автор: W. Berger; R. Fl?ckiger; H.G. K?ppe; K.T. Holmes;
Название: Metabolic Control in Diabetes Mellitus Beta Adrenoceptor Blocking Drugs NMR Analysis of Cancer Cells Immunoassay in the Clinical Laboratory Cyclosporine
ISBN: 364271000X ISBN-13(EAN): 9783642710001
Издательство: Springer
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Цена: 18167.00 р.
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Описание: The close association between blood glucose control and the well-being of the patient, as well as the risk for the development of the "late" complications of 3 diabetes, make it necessary to attain near normalisation of blood glucosel- ).

Arrestins - Pharmacology and Therapeutic Potential

Автор: Vsevolod V. Gurevich
Название: Arrestins - Pharmacology and Therapeutic Potential
ISBN: 3642411983 ISBN-13(EAN): 9783642411984
Издательство: Springer
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Цена: 43100.00 р.
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Описание: This volume in Springer`s authoritative series on experimental pharmacology covers the molecular mechanisms and therapeutic implications of arrestin-mediated signaling, including the potential of re-engineered signaling proteins in the field of gene therapy.

Arrestins - Pharmacology and Therapeutic Potential

Автор: Vsevolod V. Gurevich
Название: Arrestins - Pharmacology and Therapeutic Potential
ISBN: 3662522993 ISBN-13(EAN): 9783662522998
Издательство: Springer
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Цена: 43100.00 р.
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Описание: This volume in Springer`s authoritative series on experimental pharmacology covers the molecular mechanisms and therapeutic implications of arrestin-mediated signaling, including the potential of re-engineered signaling proteins in the field of gene therapy.

Alzheimer`s Disease: Cellular and Molecular Aspects of Amyloid beta

Автор: J. Robin Harris; Falk Fahrenholz
Название: Alzheimer`s Disease: Cellular and Molecular Aspects of Amyloid beta
ISBN: 1461498414 ISBN-13(EAN): 9781461498414
Издательство: Springer
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Цена: 30745.00 р.
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Описание: To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Автор: M.B. Sporn; Sonia B. Jakowlew
Название: Transforming Growth Factor-Beta in Cancer Therapy, Volume I
ISBN: 161737735X ISBN-13(EAN): 9781617377358
Издательство: Springer
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Цена: 36197.00 р.
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Описание: Transforming Growth Factor- ss in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ss (TGF- ss) in cancer treatment and therapy.

Transforming Growth Factor-Beta Protocols

Автор: Philip H. Howe
Название: Transforming Growth Factor-Beta Protocols
ISBN: 1489943986 ISBN-13(EAN): 9781489943989
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Concise and highly practical, Transforming Growth Factor-Beta Protocols provides today`s molecular and cell biologists-both expert and novice-with time-tested methods for the identification and analysis of the signal transduction pathways by which TGFss induces and modulates physiological behavior.

Transforming Growth Factor-Beta in Cancer Therapy, Volume II

Автор: C.-H. Heldin; Sonia B. Jakowlew
Название: Transforming Growth Factor-Beta in Cancer Therapy, Volume II
ISBN: 1617377368 ISBN-13(EAN): 9781617377365
Издательство: Springer
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Цена: 38992.00 р.
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Описание: Transforming Growth Factor- ss in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ss (TGF- ss) in cancer treatment and therapy. The companion volume details the role of TGF- ss on basic and clinical biology.


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