Alzheimer`s Disease: Cellular and Molecular Aspects of Amyloid beta, J. Robin Harris; Falk Fahrenholz
Автор: Michael R. D`Andrea Название: Intracellular Consequences of Amyloid in Alzheimer`s Disease ISBN: 0128042567 ISBN-13(EAN): 9780128042564 Издательство: Elsevier Science Рейтинг: Цена: 8083.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: . Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. . Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.
This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins.
Автор: Lucyna Antkiewicz-Michaluk; Hans Rommelspacher Название: Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants ISBN: 1489987541 ISBN-13(EAN): 9781489987549 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reports, for the first time, results from behavioral, neurochemical and molecular experiments which demonstrate a range of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.
Автор: Jacob B Natvig; ?ystein F?rre; Gunnar Husby; Anne Название: Amyloid and Amyloidosis 1990 ISBN: 9401054509 ISBN-13(EAN): 9789401054508 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the VIth International Symposium on Amyloidosis, held in Oslo, Norway, 5-8 August 1990.
Автор: T. Isobe Название: Amyloid and Amyloidosis ISBN: 1475703007 ISBN-13(EAN): 9781475703009 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Sandal, Massimo Название: Early Stage Protein Misfolding and Amyloid Aggregation ISBN: 012812251X ISBN-13(EAN): 9780128122518 Издательство: Elsevier Science Рейтинг: Цена: 29476.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.
The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists.
Автор: Einar M. Sigurdsson Название: Amyloid Proteins ISBN: 1617375020 ISBN-13(EAN): 9781617375026 Издательство: Springer Рейтинг: Цена: 13969.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Part I. In Vitro Assays Preparation of Aggregate-Free, Low Molecular Weight Amyloid-b for Assembly and Toxicity Assays Gal Bitan and David B. Teplow Determination of Peptide Oligomerization State Using Rapid Photochemical Crosslinking Sabrina S. Vollers, David B. Teplow, and Gal Bitan In Vitro Preparation of Prefibrillar Intermediates of Amyloid-b and a-Synuclein Hilal A. Lashuel and Dolors Grillo-Bosch Purification of Recombinant Tau Protein and Preparation of Alzheimer-Paired Helical Filaments In Vitro Stefan Barghorn, Jacek Biernat, and Eckhard Mandelkow Cyclic Amplification of Protein Misfolding and Aggregation Paula Saб, Joaquнn Castilla, and Claudio Soto X-Ray Diffraction Studies of Amyloid Structure O. Sumner Makin and Louise C. Serpell Molecular Electron Microscopy Approaches to Elucidating the Mechanisms of Protein Fibrillogenesis Hilal A. Lashuel and Joseph S. Wall Time-Lapse Atomic Force Microscopy in the Characterization of Amyloid-Like Fibril Assembly and Oligomeric Intermediates Claire Goldsbury and Janelle Green Fourier Transform Infrared and Circular Dichroism Spectroscopies for Amyloid Studies Miguel Calero and Marнa Gasset Quasielastic Light Scattering for Protein Assembly Studies Aleksey Lomakin, David B. Teplow, and George B. Benedek Intrinsic Fluorescent Detection of Tau Conformation and Aggregation Martin von Bergen, Li Li, and Eckhard Mandelkow Quantitative Measurement of Fibrillogenesis by Mass Spectrometry Andrew D. Miranker Part II. Cell Culture Assays Isolation and Culturing of Human Vascular Smooth Muscle Cells Finnbogi R. Thormodsson and Ingvar H. Olafsson Murine Cerebrovascular Cells as a Cell Culture Model for Cerebral Amyloid Angiopathy: Isolation of Smooth Muscle and Endothelial Cells From MouseBrain Sonia S. Jung and Efrat Levy Purification of Human Wild-Type or Variant Cystatin C From Conditioned Media of Transfected Cells Frances Prelli, Monika Pawlik, Blas Frangione, and Efrat Levy Prion Propagation in Cell Culture Sylvain Lehmann Part III. In Vivo-Related Assays Preparation and Propagation of Amyloid-Enhancing Factor Robert Kisilevsky Purification of Amyloid Protein AA Subspecies From Amyloid-Rich Human Tissues Gunilla T. Westermark and Per Westermark Purification of Transthyretin and Transthyretin Fragments From Amyloid-Rich Human Tissues Per Westermark and Gunilla T. Westermark Extraction and Chemical Characterization of Tissue-Deposited Proteins From Minute Diagnostic Biopsy Specimens Fernando Goсi and Gloria Gallo Tissue Processing Prior to Protein Analysis and Amyloid-b Quantitation Stephen D. Schmidt, Ying Jiang, Ralph A. Nixon, and Paul M. Mathews ELISA Method for Measurement of Amyloid-b Levels Stephen D. Schmidt, Ralph A. Nixon, and Paul M. Mathews Histological Staining of Amyloid-b in Mouse Brains Einar M. Sigurdsson The Mouse Model for Scrapie: Inoculation, Clinical Scoring, and Histopathological Techniques Harry C. Meeker, Xuemin Ye, and Richard I. Carp Radiolabeling of Amyloid-b Peptides Miguel Calero and Jorge Ghiso In Vivo Imaging of Amyloid-b Deposits in Mouse Brain With Multiphoton Microscopy Jesse Skoch, Gregory A. Hickey, Stephen T. Kajdasz, Bradley T. Hyman, and Brian J. Bacskai Magnetic Resonance Imaging of Amyloid Plaques in Transgenic Mice Youssef Zaim Wadghiri, Einar M. Sigurdsson, Thomas Wisniewski, and Daniel H. Turnbull Index
Автор: Einar M. Sigurdsson; Miguel Calero; Mar?a Gasset Название: Amyloid Proteins ISBN: 149395623X ISBN-13(EAN): 9781493956234 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In its new edition, this Methods in Molecular Biology (TM) book offers protocols for preparing amyloid and its precursors, cell culture models, extraction from tissue, detection in vitro and in vivo and nontransgenic methods for developing amyloid mouse models.
Автор: Bimal K. Banik Название: Beta-Lactams ISBN: 3319556207 ISBN-13(EAN): 9783319556208 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds.
Описание: Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades.
Автор: David Eliezer Название: Protein Amyloid Aggregation ISBN: 1493950053 ISBN-13(EAN): 9781493950058 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume focuses on methods for the characterization of aggregation processes that lead to the formation of amyloid fibrils and amyloid oligomers which feature in the etiology of a variety of human disorders collectively known as amyloidoses.
Автор: Derreumaux Philippe Название: Alzheimer`s Disease: Insights into Low Molecular Weight and ISBN: 1848167547 ISBN-13(EAN): 9781848167544 Издательство: World Scientific Publishing Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Alzheimer`s disease is the most common form of senile dementia, affecting more than 24 million people worldwide. This book provides a panoramic view across in vitro and in vivo studies along with computer simulations, designed to increase the readers` understanding of oligomerisation and fibril formation.
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