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Nucleic Acids in Innate Immunity, 


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Название:  Nucleic Acids in Innate Immunity
ISBN: 9780367387297
Издательство: Taylor&Francis
Классификация:

ISBN-10: 0367387298
Обложка/Формат: Paperback
Страницы: 304
Вес: 1.24 кг.
Дата издания: 27.09.2019
Язык: English
Размер: 231 x 155 x 18
Читательская аудитория: Tertiary education (us: college)
Основная тема: Infectious Diseases
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.

Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.

The second section focuses on the therapeutic applications of immunomodulatory DNA by manipulating released pathogenic nucleic acids as immune system stimulants. The book introduces novel therapeutics developed to prevent or treat infectious diseases, allergic disorders, and cancer, as well as clearing unnecessary or abnormal host molecules.

The final section addresses how the immune system discriminates self and non-self RNA. Recent findings that host (self) nucleic acids are not inert in the immune system beg the question of exactly what elements within DNA or RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation.

Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.




Innate Immunity

Автор: R. Alan B. Ezekowitz; Jules A. Hoffmann
Название: Innate Immunity
ISBN: 1468497464 ISBN-13(EAN): 9781468497465
Издательство: Springer
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Цена: 19564.00 р.
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Описание: The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms.

MIF Family Cytokines in Innate Immunity and Homeostasis

Автор: Richard Bucala; J?rgen Bernhagen
Название: MIF Family Cytokines in Innate Immunity and Homeostasis
ISBN: 331952352X ISBN-13(EAN): 9783319523521
Издательство: Springer
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Цена: 22359.00 р.
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Описание: The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established.

Innate Immunity of Plants, Animals and Humans

Автор: Holger Heine
Название: Innate Immunity of Plants, Animals and Humans
ISBN: 3662518082 ISBN-13(EAN): 9783662518083
Издательство: Springer
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Цена: 30745.00 р.
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Описание: All living organisms are in a constant battle against their environment. Since uncontained microorganisms would simply overgrow all higher animals, the evolution of multicellular organisms required adequate and efficient defense mechanisms to protect their own integrity and to ensure their own survival. These defense mechanisms, encompassing receptor proteins that sense the presence of pathogens and effector molecules that are involved in controlling them, are the elemental parts of the innate immune system. For many species, the innate immune system is the sole active defense system. Long thought to be an unspecific immune response, the discovery of the Toll-like receptors and their ligands finally revealed just how specific the innate immune response actually is. This book wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system.

Antimicrobial Peptides and Innate Immunity

Автор: Pieter S. Hiemstra; Sebastian A. J. Zaat
Название: Antimicrobial Peptides and Innate Immunity
ISBN: 3034807678 ISBN-13(EAN): 9783034807678
Издательство: Springer
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Цена: 22201.00 р.
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Описание: This book details the evolution of cysteine-containing antimicrobial peptides and their role in host defense in plants and micro-organisms. It also examines the role of antimicrobial peptides in disease and gives an outlook on new therapeutic options.

Innate Antiviral Immunity

Автор: Karen Mossman
Название: Innate Antiviral Immunity
ISBN: 1493972367 ISBN-13(EAN): 9781493972364
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book explores methods to study the complex and evolving interplay between a virus and its host that range from model systems to the detection of chemical molecules.

Crossroads Between Innate and Adaptive Immunity V

Автор: Stephen P. Schoenberger; Peter D. Katsikis; Bali P
Название: Crossroads Between Innate and Adaptive Immunity V
ISBN: 3319372289 ISBN-13(EAN): 9783319372280
Издательство: Springer
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Цена: 16977.00 р.
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Описание: This meeting was the fifth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity.

Innate Immunity

Автор: Carton, Yves
Название: Innate Immunity
ISBN: 1785483080 ISBN-13(EAN): 9781785483080
Издательство: Elsevier Science
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Цена: 26107.00 р.
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Описание:

Innate immunity is a new branch of immunology, confirmed by three Nobel Prize winners in 2011. It is the first line of defense against pathogens and is in a way the preliminary step of adaptive immunity which occurs later, and only present in vertebrates.

This book examines the way in which innate immunity was discovered in invertebrates. As a starting point, it looks at the work of Louis Pasteur on silkworm disease and the findings of Ilya Metchnikov, discoverer of phagocytosis. It also investigates Andr Paillot, who in 1920 demonstrated the existence of humoral immunity in insects, unrelated to the type of immunity that was initially thought to be present in all vertebrates.

Finally, Innate Immunity shows how the group directed by Jules Hoffmann found strong similarities between the innate immunity response of insects and mammals. The discovery of a receptor protein in Drosophila, which is also found in humans, was what led to Jules Hoffmann being awarded the Nobel Prize in 2011.

Mouse Models of Innate Immunity

Автор: Irving C. Allen
Название: Mouse Models of Innate Immunity
ISBN: 1493960369 ISBN-13(EAN): 9781493960361
Издательство: Springer
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Цена: 14673.00 р.
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Описание: The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense;

Crossroads between Innate and Adaptive Immunity II

Автор: Stephen P. Schoenberger; Peter D. Katsikis; Bali P
Название: Crossroads between Innate and Adaptive Immunity II
ISBN: 1441927182 ISBN-13(EAN): 9781441927187
Издательство: Springer
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Цена: 32004.00 р.
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Описание: This volume includes mini-reviews derived from work presented at the Aegean Conference: Second Crossroads between Innate and Adaptive Immunity, in Crete, Greece, June 17-22, 2007.

Current Topics in Innate Immunity

Автор: John D. Lambris
Название: Current Topics in Innate Immunity
ISBN: 1441924558 ISBN-13(EAN): 9781441924551
Издательство: Springer
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Цена: 32651.00 р.
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Описание: In the post genomic era, understanding of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation.

Innate and Adaptive Immunity in the Tumor Microenvironment

Автор: Yefenof
Название: Innate and Adaptive Immunity in the Tumor Microenvironment
ISBN: 9048177138 ISBN-13(EAN): 9789048177134
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host.


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