UN Millennium Development Library: Coming to Grips with Malaria in the New Millennium, Millennium Project, UN
Автор: Zach N. Adelman Название: Genetic Control of Malaria and Dengue ISBN: 0128002468 ISBN-13(EAN): 9780128002469 Издательство: Elsevier Science Рейтинг: Цена: 11115.00 р. Наличие на складе: Поставка под заказ.
Описание:
Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies.
For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown.
Описание: Details the key achievements of the Regional Malaria and Other Communicable Disease Threats Trust Fund from its creation in 2013 to the first half of 2018. The report provides detailed analysis of the results by outcome, profiles specific projects that serve as exemplars of the fund`s impact, and offers insights managing similar trust funds.
Автор: Henry M. Staines; Sanjeev Krishna Название: Treatment and Prevention of Malaria ISBN: 3034808089 ISBN-13(EAN): 9783034808088 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs.
Описание: Following the story through the dwindling campaign in the late 1960s and early 1970s, Cueto raises questions relevant to today`s international health campaigns against malaria, AIDS, and tuberculosis.
Автор: Sherman Irwin W Название: Malaria Vaccines: The Continuing Quest ISBN: 1786340046 ISBN-13(EAN): 9781786340047 Издательство: World Scientific Publishing Рейтинг: Цена: 17424.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
In 2013, 200 million people were infected with malaria, resulting in over 584,000 deaths, with the potential to affect over half the world's population. Such is the widespread nature of malaria that it is increasingly believed only a vaccine will lead to its eradication.
Although the first attempt at a vaccine was made a century ago, it is only in the last 30 years that real progress in testing has been made, in the hope of discovering a molecule that can provide long-lasting protection against the disease. In July 2015, GlaxoSmithKline (GSK) announced that after 30 years of research it had received the green light from the European Medicines Agency for the world's first malaria vaccine, RTS, S, for use in African children aged 6 weeks to 17 months.
This book chronicles the development of RTS, S -- done in collaboration with the Walter Reed Army Institute for Research, the PATH Malaria Vaccine Initiative (MVI) and funded in part by the Bill and Melinda Gates Foundation -- as well as previous candidate vaccines. It also focusses on the continuing quest to find more effective vaccines against this continuing health crisis. Finally, it provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development.
This book serves as a convenient and easily accessible source of information for students, teachers, microbiologists, parasitologists, physicians, clinicians and research funders.
Автор: Krishna R. Dronamraju; Paolo Arese Название: Malaria ISBN: 1441921028 ISBN-13(EAN): 9781441921024 Издательство: Springer Рейтинг: Цена: 24456.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called "Malaria Hypothesis", that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane's contribution from two directions: (a) it has been suggested that the "Malaria Hypothesis" was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane's malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts.
Название: Traditional Medicinal Plants and Malaria ISBN: 0367394111 ISBN-13(EAN): 9780367394110 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Malaria is an increasing worldwide threat, with more than three hundred million infections and one million deaths every year. The world's poorest are the worst affected, and many treat themselves with traditional herbal medicines. These are often more available and affordable, and sometimes are perceived as more effective than conventional antimalarial drugs.
The first book to be published on this subject, Traditional Medicinal Plants and Malaria explores the evidence for the safety and efficacy of some of these traditional medicines, and presents practical guidelines for designing studies on traditional plant-based antimalarial medicines, mosquito repellents, and insecticides. Systematic reviews of the literature and consensus guidelines form the main body of the book. Ethnomedical, ethnobotanical, pharmacological, phytochemical, toxicological, and clinical aspects of herbal antimalarials are also reviewed. These are supplemented by case studies of the most well-known traditional antimalarials.
Автор: Jos? A. Stoute Название: Complement Activation in Malaria Immunity and Pathogenesis ISBN: 3030084124 ISBN-13(EAN): 9783030084127 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.
Автор: Addmore Shonhai; Gregory L. Blatch Название: Heat Shock Proteins of Malaria ISBN: 9402402594 ISBN-13(EAN): 9789402402599 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes the role of heat shock proteins in the life cycle of malaria parasites. It examines the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology.
Автор: Jacques Derek Charlwood Название: The Ecology of Malaria Vectors ISBN: 0367248484 ISBN-13(EAN): 9780367248482 Издательство: Taylor&Francis Рейтинг: Цена: 11482.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This practical book covers all aspects of the biology of malaria vectors, with notes on the vectors of dengue. It is designed to fill the gap between very specialised texts and undergraduate books on general disease vectors, and is ideal as a textbook for postgraduate courses in entomology and mosquito vectors of disease.
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