Автор: Walsh Название: Antibiotics: Challenges, Mechanisms, Opportunities ISBN: 1555819303 ISBN-13(EAN): 9781555819309 Издательство: Wiley Рейтинг: Цена: 16466.00 р. Наличие на складе: Поставка под заказ.
Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Автор: Westley Название: Polyether Antibiotics ISBN: 0824718887 ISBN-13(EAN): 9780824718886 Издательство: Taylor&Francis Рейтинг: Цена: 39811.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This collection of essays will stimulate the use of ionophores in different research areas. It includes information on potential breakthroughs in the halogenated derivatives of lasalocid and ethers of antibiotic A204A, polyethers and analytical techniques used to unravel their complex structures.
Автор: G.G. Gallo; G. Lancini; F. Parenti Название: Antibiotics ISBN: 0306449242 ISBN-13(EAN): 9780306449246 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this translation of the Italian second edition, the authors provide a comprehensive account of the current knowledge on antibiotics. Their work also discusses the industrial and clinical development of new antibiotics, as well as the questions and controversies related to the function of antibiotics in nature.
Автор: Giancarlo Lancini; Betty Rubin; Francesco Parenti Название: Antibiotics ISBN: 1461256763 ISBN-13(EAN): 9781461256762 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antibiotics are among the most widely prescribed drugs in both human and veterinary medicine. When we started to teach our course on the science of antibiotics at the University of Pavia and the University of Milan, we realized that there was no book that presented the basic facts and concepts on all aspects of this diverse science.
Автор: Hamao Umezawa; Irving R. Hooper; Y. Ito; Irving R. Название: Aminoglycoside Antibiotics ISBN: 3642685811 ISBN-13(EAN): 9783642685811 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Conte Название: Manual of Antibiotics and Infectious Diseases ISBN: 0781723167 ISBN-13(EAN): 9780781723169 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 5491.00 р. Наличие на складе: Поставка под заказ.
Описание: Manual of Antibiotics and Infectious Diseases: Treatment and Prevention was designed for health-care professionals involved in the daily care of patients with infectious diseases. The book covers antibiotics currently available, their doses, and their dose adjustments. It explains what to do when faced with renal failure, as well as empirical, prophylactic, and definitive antibiotic therapies--everything from bacteria resistance to AIDS therapies. A new section on hospital epidemiology and infection control is included in this Ninth Edition. A Brandon-Hill recommended title.
Автор: Sabine Enenkel; Wolfgang Stille Название: Antibiotics in the Tropics ISBN: 3540186832 ISBN-13(EAN): 9783540186830 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since it is the aim of the book to base treatment recommenda- tions on data from developing countries, many data on the etiology of common bacterial infections in developing countries have also been included.
Описание: The 1st Euchem Symposium on the Chemical Synthesis of Antibiotics was held in Aussois in Savoie, France on May 2-6, 1988 thanks to the efforts of Prof. G. Lukacs, chairperson, and Prof. F. Arcamone and Prof. P. Welzel, vice-chairpersons of the International Organizing Committee. Following the great success of the Ist Symposium, the 2nd Symposium, which was chaired by Prof. Ohno, was held in Oiso, Japan in 1990. The 3rd Symposium, chaired by Prof. K. Krohn, was held in Kloster Banz, Germany in 1992. It has been decided that the 4th Symposium will take place in the United States in 1994 and be chaired by Dr. H. A. Kirst of Lilly Research Laboratories. The Euchem Symposium has come to serve as an important symposium where one can understand the development and the future directions of the chemical synthesis of antibiotics and other bioactive metabolites from microorganisms. Prof. G. Lukacs, in cooperation with Prof. M. Ohno, edited the book "Recent Progress in the Chemical Synthesis of Antibiotics" three years ago. Most of its contributors were the participants of the Aussois Symposium. This book attracted the attention of researchers specializing in organic synthesis and stimulated considerable progress in this field.
Автор: W. Sch?nfeld; H.A. Kirst Название: Macrolide Antibiotics ISBN: 3034894384 ISBN-13(EAN): 9783034894388 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The following group of chapters cover the complex chemistry of the macro- lactone structures, giving historic background, basic structure-activity relation- ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.
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