Описание: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. www.springeronline.com
Автор: Michelle A. Rudek; Cindy H. Chau; William D. Figg; Название: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics ISBN: 1461491347 ISBN-13(EAN): 9781461491347 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers a detailed, step-by-step guide to the successful design and approval of anticancer drugs. It covers all steps, from the identification of cancer-specific molecular targets to clinical trial design and all the phases of clinical trials.
Описание: Updated with the latest clinical advances, Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
More than 200 carefully written study questions, with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
New and updated examples connect chapter content to real-world settings.
Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
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Автор: Hedaya, Mohsen A. , Puri, Basant K. Название: Making Sense of Pharmacokinetics and Pharmacodynamics ISBN: 0367140918 ISBN-13(EAN): 9780367140915 Издательство: Taylor&Francis Рейтинг: Цена: 3367.00 р. Наличие на складе: Поставка под заказ.
Описание: Making Sense of Pharmacokinetics and Pharmacodynamics has been written as a practical and accessible guide to help the student and more experienced practitioner navigate these complex areas in order to understand better how drugs work and how, in turn, this knowledge underpins appropriate prescribing decisions.
Автор: Michelle A. Rudek; Cindy H. Chau; William D. Figg; Название: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics ISBN: 1493938983 ISBN-13(EAN): 9781493938988 Издательство: Springer Рейтинг: Цена: 34937.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. * Road map to anticancer drug development from discovery to NDA submission * Discussion of molecular targets and preclinical screening * Development and validation of bioanalytical methods * Chapters on clinical trial design and phase 0, I, II, III clinical trials * Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents * Review of the drug development process from both laboratory and clinical perspectives * New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Описание: Proceedings of a conference sponsored by the American Association of Pharmaceutical Scientists, the U.S. Food and Drug Administration, and the American Society for Clinical Pharmacology and Therapeutics, held in Arlington, Virginia, April 24-26, 1991
Описание: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.
Описание: Thisbook is a comprehensive resource on psychotropic medications, detailing thelatest methods for defining their characteristics, their use in differentpatient populations, and drug-drug interactions; an important collection ofinformation forclinicians, students, researchers, and members of thepharmaceutical industry alike.Thefirst section provides the foundational principles of these drugs. Mathematicalmodeling of parameters that affect their entryto,and exit from, the centralnervous system (CNS) compartment are presented on an individual basis and thenapplied to target populations with specific disease states. Methods andcharacteristics that inform the transfer of these drugs from the laboratorybench to use in patient care are discussed, including imaging techniques,genetics and physiological barriers, such as the blood-brain barrier. The secondsection describes the characteristics of specific agents,nominally arrangedintodifferent therapeutic categories and with reference crossover use indifferent disease states. The pharmacologic characteristics of different drugformulations are explored in the context of their ability to improve patientadherence. The third section focuses on drug-drug interactions.Psychotropic medicationsfrom different categories are frequently prescribed together,or alongsidemedications used to treat comorbid conditions, and the information provided isdirectly relevant to the clinic, as a result.Theclinical application of pharmacokinetics and pharmacodynamics of CNS agents hasmade significant progress over the past 50 years and new information is reportedby numerous publications in psychiatry, neurology, and pharmacology.Ourunderstanding of the interrelationship between these medications, receptors,drug transporters, as well as techniques for measurement and monitoring theirinteractions,isfrequently updated. However, with information presented on ahost of different platforms, and in different formats, obtaining the fullpicture can be difficult. This title aims to collate this information into asingle source that can be easily interpreted and applied towards patient careby the clinical practitioner, and act as a reference for all others who have aninterest in psychopharmacological agents.
Описание: This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.
Автор: Alexander A. Vinks; Hartmut Derendorf; Johan W. Mo Название: Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics ISBN: 1493950819 ISBN-13(EAN): 9781493950812 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
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