Emery And Rimoin`S Principles And Practice Of Medical Genetics And Genomics, Pyeritz, Reed E.
Старое издание
Автор: Rimoin, David L. Название: Emery And Rimoin`S Essential Medical Genetics ISBN: 0124072402 ISBN-13(EAN): 9780124072404 Издательство: Elsevier Science Цена: 29139.00 р. Наличие на складе: Поставка под заказ. Описание: Suitable for practicing clinicians to learn how the study of genetics can be integrated into practice, this book helps to bridge the gap between high-level molecular genetics and individual application. It follows the multi-volume set in scientific fundamentals, spectrum discussion of inherited disorders, and actionable therapies.
Автор: Strachan Название: Human Molecular Genetics ISBN: 0815345895 ISBN-13(EAN): 9780815345893 Издательство: Taylor&Francis Рейтинг: Цена: 12095.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology.
Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation.
Key features:
Fully integrated approach to the molecular aspects of human genetics, genomics, and cell biology
Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms
Summary boxes at the end of each chapter provide clear learning points
Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study
Reorganized into five sections for improved access to related topics
Also new to this edition - brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics
A proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the 'go-to' book for those studying human molecular genetics or genomics courses around the world.
Название: Principles and Practices of Plant Genomics, Volume 3 ISBN: 1138116491 ISBN-13(EAN): 9781138116498 Издательство: Taylor&Francis Рейтинг: Цена: 10717.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book presents the basic and applied aspects of sequencing of genes and genomes and their implication in the fine-scale elucidation of the plant genomes. The third volume presents an overview on the advances of plant genomics made in the past century; deliberations on the genomics resources; concepts, tools, strategies, and achievements of comparative, evolutionary, and functional genomics and whole-genome sequencing. It also presents critical reviews on the already completed genome initiatives and glimpses on the currently progressing genome initiatives. This volume is an ideal reference book for students, scholars and scientists in academia, industry, and government.
Автор: Charles, Jill Mondal, Indrani Chattopadhyay, Ranjita Chakrabarty, Ananda Название: Three daughters, three journeys ISBN: 9814745901 ISBN-13(EAN): 9789814745901 Издательство: Taylor&Francis Рейтинг: Цена: 4898.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women’s lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.
Название: Omics in Clinical Practice ISBN: 1771880600 ISBN-13(EAN): 9781771880602 Издательство: Taylor&Francis Рейтинг: Цена: 20671.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This title includes a number of Open Access chapters.
This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered.
The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized medicine. Part III focuses on molecular and genetic markers. Part IV describes the use of omics while studying pathogens, and Part V examines the applications for companion diagnostics.
The book:
- Introduces genomics, proteomics, and transcriptomics in relation to human disease and ailments
- Considers the role of translation and personalized medicine in relation to genomics, proteomics, and transcriptomics
- Covers molecular and genetic markers
- Considers the role of genomics, proteomics, and transcriptomics in relation to pathogen detection, evolution, and infection
- Covers companion diagnostics in relation to genomics, proteomics, and transcriptomics clinical applications and research
Описание: Bringing together leading experts in the field of network data analysis, this text introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning. Using real-world biological and medical examples, applications of these theories are discussed and creative thinking is encouraged in the analysis of such complex network data sets.
Автор: Michael Hehenberger, Zhi Xia Название: Our Animal Connection: What Sapiens Can Learn From Other Species ISBN: 9814800481 ISBN-13(EAN): 9789814800488 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book covers the many ways humans benefit from interactions with other living species. By studying animals of all kinds and sizes, from microbial organisms to elephants and whales, we can learn about their adaptations to extreme conditions on planet Earth, about the evolutionary development of specialized capabilities, and about their ways to defend themselves against predators and diseases. We discuss the strengths and weaknesses of Homo Sapiens, and how the study of animals can make us stronger and healthier. To increase our knowledge of genetics, molecular and cell biology, physiology and medicine, we need to study model organisms. To cure human disease, we can learn from animals how they have evolved ways to protect themselves. To improve our human performance, we can study the animal kingdom’s top performers and possibly learn from their successes. Finally, we review genetic engineering techniques that can translate our existing and future animal connections into benefits for human health and performance.
Автор: Vikas Mishra Название: Principles of Epigenetics ISBN: 1773615297 ISBN-13(EAN): 9781773615295 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 25502.00 р. Наличие на складе: Нет в наличии.
Описание: Examines various dimensions of epigenetics and its relationship to human disease. Part I deals with epigenetics in human diseases; Part II covers yeast epigenetics; Part III covers plant epigenetics.
Автор: Ian Moore Название: Principles of Proteomics ISBN: 1680945335 ISBN-13(EAN): 9781680945331 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 18183.00 р. Наличие на складе: Нет в наличии.
Описание: Proteomics is the large-scale study of proteomes. A proteome is a set of proteins produced in an organism, system, or biological context. The proteome is not constant; it differs from cell to cell and changes over time. This text is intended to give the molecular biologist a rudimentary understanding of the technologies behind proteomics and their application to address biological questions.
Описание: The increased and widespread availability of large network data resources in recent years has resulted in the increased need for effective methods for the analysis of these networks. The challenge is to detect patterns that provide a better understanding of the data. However, this is not a straight forward task because of the size of the data sets and the computer power required for the analyses. The solution is to devise methods for approximately answering the questions posed, and these methods will vary depending on the data sets under scrutiny. This cutting-edge text introduces graph and network theory, cluster analysis and machine learning, before discussing the thought processes and creativity involved in the analysis of large-scale biological and medical data sets, using a wide range of real-life examples. Bringing together leading experts, this inter-disciplinary text provides an ideal introduction to and insight into the field of network data analysis.
Автор: Thangadurai Devarajan, Sangeetha Jeyabalan Название: Genomics and Proteomics: Principles, Technologies, and Applications ISBN: 1771881143 ISBN-13(EAN): 9781771881142 Издательство: Taylor&Francis Рейтинг: Цена: 20671.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The book provides scope and knowledge on advanced techniques and its applications into the modern fields of biotechnology--genomics and proteomics. In this book, different genomics and proteomics technologies and principles are examined. The fundamental knowledge presented in this book opens up an entirely new way of approaching DNA chip technology, DNA array assembly, gene expression analysis, assessing changes in genomic DNA, structure-based functional genomics, protein networks, and so on.
Topics in the book include:
- Different gene products with a similar role in neuronal defense against oxidative
- Gene-gene and gene-environment interactions in genetic epidemiology
- Elucidation of proto-oncogene c-abl function with the use of mouse models and the disease model of chronic myeloid leukemia
- Next-generation sequencing, microbiome evaluation, molecular microbiology, and their impact on human health
- Proteomics and prostate cancer
- RNA interference therapeutics
- Molecular mechanisms of hepatitis C virus entry
- Molecular phylogenetics for elucidation of evolutionary processes from biological data
- The impact of transgenic crops on soil quality, microbial diversity, and plant-associated communities.
- Biotechnological and genomic approaches for abiotic stress tolerance in crop plants
The book will be valuable for biotechnology researchers and bioinformatics professionals and students in all fields of biotechnology and will serve to broaden their knowledge about these newer tools, techniques, innovations, and applications.
Описание: Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Cardiovascular, Respiratory, and Gastrointestinal Disorders, Seventh Edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies. This comprehensive, yet practical, resource emphasizes theory and research fundamentals relating to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine. Updated sections in this release cover the genetics of cardiovascular, respiratory and gastrointestinal disorders, with an emphasis on genetic determinants and new pathways for diagnosis, prevention and disease management.
In addition, genetic researchers, students and health professionals will find new and fully revised chapters on the molecular genetics of congenital heart defects, inherited cardiomyopathies, hypertension, cystic fibrosis, asthma, hereditary pulmonary emphysema, inflammatory bowel disease, and bile pigment metabolism disorders among other conditions.
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