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The Human Mitochondrial Genome, Gasparre, Giuseppe


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Автор: Gasparre, Giuseppe
Название:  The Human Mitochondrial Genome
ISBN: 9780128196564
Издательство: Elsevier Science
Классификация:


ISBN-10: 0128196564
Обложка/Формат: Paperback
Страницы: 448
Вес: 1.22 кг.
Дата издания: 01.08.2020
Язык: English
Размер: 235 x 191
Читательская аудитория: Professional & vocational
Подзаголовок: From basic biology to disease
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth.

With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways.




Proteins of the Mammalian Mitochondrial Ribosome

Автор: Matthews David
Название: Proteins of the Mammalian Mitochondrial Ribosome
ISBN: 0530018659 ISBN-13(EAN): 9780530018652
Издательство: Неизвестно
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Цена: 17105.00 р.
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Описание: Abstract:

2D-PAGE of bovine and rat mitoribosomal proteins

Dissertation Discovery Company and the University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "Proteins of the Mammalian Mitochondrial Ribosome" by David Earl Matthews, was obtained from the University of Florida and is being sold with permission from the author. A free digital copy of this work may also be found in the university's institutional repository, the IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.

Anion Carriers of Mitochondrial Membranes

Автор: Angelo Azzi; Katarzyna A. Nalecz; Maciej J. Nalecz
Название: Anion Carriers of Mitochondrial Membranes
ISBN: 3642745415 ISBN-13(EAN): 9783642745416
Издательство: Springer
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Цена: 15372.00 р.
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Описание: All relevant structural and functional aspects of the Anion Carriers of Mitochondrial Membranes as well as isolation procedures, reconstitution experiments and biogenesis of the carriers, kinetics of transport as well as the metabolic regulation mechanisms are treated in this volume.

Mitochondrial biology and experimental therapeutics.

Название: Mitochondrial biology and experimental therapeutics.
ISBN: 3319733435 ISBN-13(EAN): 9783319733432
Издательство: Springer
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Цена: 25155.00 р.
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Описание: This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Mitochondrial Inhibitors and Neurodegenerative Disorders

Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong
Название: Mitochondrial Inhibitors and Neurodegenerative Disorders
ISBN: 089603805X ISBN-13(EAN): 9780896038059
Издательство: Springer
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Цена: 34799.00 р.
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Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.

Mitochondrial Biology and Experimental Therapeutics

Автор: Paulo J. Oliveira
Название: Mitochondrial Biology and Experimental Therapeutics
ISBN: 3030103587 ISBN-13(EAN): 9783030103583
Издательство: Springer
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Цена: 25155.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Mitochondrial DNA Mutations in Aging, Disease and Cancer

Автор: Keshav K. Singh
Название: Mitochondrial DNA Mutations in Aging, Disease and Cancer
ISBN: 3662125110 ISBN-13(EAN): 9783662125113
Издательство: Springer
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Цена: 16979.00 р.
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Описание: Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson`s, Alzheimer`s, and Huntington`s diseases.

Molecular Biology of Mitochondrial Transport Systems

Автор: Michael Forte; Marco Colombini
Название: Molecular Biology of Mitochondrial Transport Systems
ISBN: 3642789382 ISBN-13(EAN): 9783642789380
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Proceedings of the NATO Advanced Research Workshop on Molecular Biology of Mitochondrial Transport Systems, held at Il Ciocco, Italy, September 17 - 21, 1992

Mitochondrial Dysfunction in Neurodegenerative Disorders

Автор: Reeve
Название: Mitochondrial Dysfunction in Neurodegenerative Disorders
ISBN: 3319286358 ISBN-13(EAN): 9783319286358
Издательство: Springer
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Цена: 18866.00 р.
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Описание: This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson’s disease, Alzheimer’s disease and multiplesclerosis. The reader is guided through the basic functions of mitochondria andthe mechanisms that lead to their dysfunction, and on to the consequences ofthis dysfunction for neuronal function before finishing with the modelling ofthese disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflectadvances in the field and there are many new contributors and topics, includinghow mitochondria are degraded and the interaction of the mitochondria withpathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disordersprovides an accessible, authoritative guide to this important area forneurologists; research and clinical neuroscientists; neuropathologists; andresidents with an interest in clinical research.

Mitochondrial Bioenergetics

Автор: Carlos M. Palmeira; Ant?nio J. Moreno
Название: Mitochondrial Bioenergetics
ISBN: 1493958372 ISBN-13(EAN): 9781493958375
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This Methods in Molecular Biology (TM) book offers practical principles and assays designed to derive quantitative assessment of each set of parameters that reflect different aspects of mitochondrial bioenergetics. Includes protocols, materials lists and tips.


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