Human Pluripotent Stem Cell Derived Organoid Models,159, Spence, J.

Автор: Ulrich Martin; Robert Zweigerdt; Ina Gruh
Название: Engineering and Application of Pluripotent Stem Cells
ISBN: 3030088170 ISBN-13(EAN): 9783030088170
Издательство: Springer
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Цена: 34937.00 р.
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Описание: ?This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening.This book will appeal to researchers working in regenerative medicine and drug discovery, and to bioengineers and professionals interested in stem cell research.

Автор: Uma Lakshmipathy; Mohan C Vemuri
Название: Pluripotent Stem Cells
ISBN: 149396285X ISBN-13(EAN): 9781493962853
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Human pluripotent stem cells such as human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) with their unique developmental plasticity hold immense potential as cellular models for drug discovery and in regenerative medicine as a source for cell replacement. While hESC are derived from a developing embryo, iPSC are generated with forced expression of key transcription factors to convert adult somatic cells to ESC-like cells, a process termed reprogramming. Using iPSC overcomes ethical issues concerning the use of developing embryos and it can be generated from patient-specific or disease-specific cells for downstream applications. Pluripotent Stem Cells: Methods and Protocols highlights the best methods and systems for the entire work flow. Divided into four convenient sections, topics include a focus on producing iPSC from diverse somatic sources, media systems for expanding ESC and iPSC with detailed protocols for directed differentiation into specific lineages, commonly used cellular and molecular characterization methods , and the potential application of labeled stem cells with specific methods for cloning, gene delivery and cell engineering. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Pluripotent Stem Cells: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential cellular feature.

Автор: J?rgen Hescheler; Erhard Hofer
Название: Adult and Pluripotent Stem Cells
ISBN: 9401786569 ISBN-13(EAN): 9789401786560
Издательство: Springer
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Цена: 19564.00 р.
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Описание: There is hardly an area of research developing so quickly and raising so many promises as stem cell research. Adult, embryonic and recently available induced pluripotent stem cells not only foster our understanding of differentiation of endo-, ecto- and mesodermal lineages to all organs of the body, but foremost nourish the hope that cells grown in culture can be used for regeneration of diseased organs such as the heart damaged by myocardial infarction. This book focuses on perspectives of stem cells for regenerative therapy of cardiovascular diseases. Based on the EC consortium INELPY, it reviews the field and disseminates major outcomes of this project. Thus it introduces the reader to this fascinating area of research and incorporates very recent findings interesting to the expert, spanning the field from bench to bedside. The compilation of contributions is unique as there is yet no similar comprehensive overview combining stem cell research with preclinical and clinical evaluation as well as engineering of tissue patches for transplantation. As such it will be an invaluable source of information for all researchers in the stem cell and tissue regeneration field including bioengineers as well as for all clinicians interested in regenerative therapies, especially for ischemic cardiomyopathies.

Автор: Martin
Название: Engineering and Application of Pluripotent Stem Cells
ISBN: 331973590X ISBN-13(EAN): 9783319735900
Издательство: Springer
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Цена: 41925.00 р.
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Описание: This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening. This book will appeal to researchers working in regenerative medicine and drug discovery, and to bioengineers and professionals interested in stem cell research.

Автор: Mike Clements; Liz Roquemore
Название: Stem Cell-Derived Models in Toxicology
ISBN: 1493966596 ISBN-13(EAN): 9781493966592
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies.

Автор: Xiaoyang Zhao
Название: Studies of pluripotency in embryonic stem cells and induced
ISBN: 9401788189 ISBN-13(EAN): 9789401788182
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This book covers methods to derive embryonic stem cells (ESCs) from several different species. It describes an efficient system to generate induced pluripotent stem cells (iPSCs) and reports on iPSC mice.

Автор: Andras Nagy; Kursad Turksen
Название: Patient-Specific Induced Pluripotent Stem Cell Models
ISBN: 149394973X ISBN-13(EAN): 9781493949731
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This volume captures the rapid developments in the field of induced pluripotent stem (iPS) cells, which have provided novel opportunities and approaches both for better understanding a number of human diseases and for developing new platforms for drug development and screening for such diseases.

Автор: Andras Nagy; Kursad Turksen
Название: Patient-Specific Induced Pluripotent Stem Cell Models
ISBN: 1493930338 ISBN-13(EAN): 9781493930333
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This volume captures the rapid developments in the field of induced pluripotent stem (iPS) cells, which have provided novel opportunities and approaches both for better understanding a number of human diseases and for developing new platforms for drug development and screening for such diseases.

Автор: Kaiming Ye; Sha Jin
Название: Human Embryonic and Induced Pluripotent Stem Cells
ISBN: 1493958933 ISBN-13(EAN): 9781493958931
Издательство: Springer
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Цена: 25155.00 р.
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Описание: Because of the huge potential of human embryonic stem (hES) cells, especially the newly developed human induced pluripotent stem (hiPS) cells, in disease treatment and life quality improvement, enormous efforts have been made to develop new methodologies to translate lab discoveries in stem cell research into bed-side clinical technologies. In Human Embryonic and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols, experts in the field present a comprehensive collection of protocols designed for labs around the world. The topics covered in this detailed volume include techniques used for maintenance of hES and iPS cells in either small or large scale, techniques for directing hES and iPS cell lineage specification, techniques for enhancing the maturity of differentiated hES and iPS cells within three-dimensional scaffolds, techniques for reprogramming adult cells into iPS cells, techniques for generating patient-specific iPS cells, and techniques for translating hES and iPS cell research into new therapies. Chapters include lab ready protocols with tips on troubleshooting and avoiding known pitfalls. Wide-ranging and authoritative, Human Embryonic and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols will be a tremendous aid for researchers and students who wish to explore these areas and transform their discoveries into the next generation of regenerative medicine and tissue engineering technologies.

Автор: Philip H. Schwartz; Robin L. Wesselschmidt
Название: Human Pluripotent Stem Cells
ISBN: 149395802X ISBN-13(EAN): 9781493958023
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This authoritative book is as an ideal guide to scientists conducting their own pluripotent cell research programs. The book aims to assist those making strides in this field towards furthering human knowledge and, ultimately, improving the human condition.

Автор: Kursad Turksen; Andras Nagy
Название: Induced Pluripotent Stem (iPS) Cells
ISBN: 1493979817 ISBN-13(EAN): 9781493979813
Издательство: Springer
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Цена: 18167.00 р.
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Автор: Kapil Bharti
Название: Pluripotent Stem Cells in Eye Disease Therapy
ISBN: 3030284700 ISBN-13(EAN): 9783030284701
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. Chapters are contributed by experts in the field and cover such topics as the use of pluripotent stem cells in 2D and 3D engineering of ocular tissues for disease modelling and drug testing as well as approaches to replace degenerated RPE and photoreceptors in macular degeneration and retinitis pigmentosa. Pluripotent Stem Cells in Eye Disease Therapy presents a comprehensive discussion of basic science and clinical applications and is an indispensable resource for everyone from advanced graduate students to advanced professionals who want to learn about the potential of stem cell biology and its role in the field of retinal diseases.