Описание: Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.
Автор: R.G.G. Russell; T.M. Skerry; U. Kollenkirchen Название: Novel Approaches to Treatment of Osteoporosis ISBN: 3662090090 ISBN-13(EAN): 9783662090091 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Current treatments are based on prevention of further bone loss after the condition is diagnosed, often because a fracture has occurred. Treatments in the future will aim at healing osteoporosis by improving bone mass and quality. This book describes novel discoveries and research which will allow bone to be restored after it has been lost.
Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology.
The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field.
By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner.
Описание: This book is the first to provide a comprehensive review of recent progress and challenges in the risk assessment of nanomaterials by empirical and computational techniques.
Автор: Alexandru Mihai Grumezes Название: Novel Approaches of Nanotechnology in Food ISBN: 0128043083 ISBN-13(EAN): 9780128043080 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Health and well-being are key drivers for the food industry. Market forces necessitate innovation throughout the whole food chain, from sourcing raw materials and ingredients, food processing, quality control of finished products, and packaging. Nanotechnology, coupled with novel interdisciplinary approaches and processing methods, can help resolve the huge challenges faced by the food and bioprocessing industries to develop and implement systems that produce qualitative and quantitative foods which are safe, sustainable, environmentally friendly, and efficient.
The first volume in the "Nanotechnology in the Food Industry" series, "Novel Approaches of Nanotechnology in Food" is a comprehensive overview of the various potential applications of nanotechnology in the field of food science and its successful and effective implementation. It is a broad introduction to the success of nanotechnology and potential future advancements of this technology within the food industry, and provides a reference of how novel approaches to nanotechnology can advance all of food science through proven research results and industrial applications. Includes the most up-to-date information on nanotechnology applications within the food industryPresents various approaches for innovation based on scientific advancements in the field of nanotechnologyProvides methods and techniques for research analysis using novel technologies across the food chainCovers potential benefits and methods of risk assessment for food safety
Автор: Ahsan, Amimul Название: Nanotechnology in Water and Wastewater Treatment ISBN: 0128139021 ISBN-13(EAN): 9780128139028 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Nanotechnology in Water and Waste Water Treatment: Theory and Applications explores the unique physicochemical and surface properties of nanoparticles and highlights the advantages they provide for engineering applications. Applications covered include the generation of fresh water from surface water and seawater, the prevention of the contamination of the environment, and the creation of effective and efficient methods for remediation of polluted waters. Each chapter covers a different nanotechnology-based approach and examines the basic principles, practical applications, recent breakthroughs and associated limitations. This book is ideal for researchers and professionals in the fields of nanotechnology, water treatment and desalination.
In addition, it is also ideal for postgraduate students, industry and government professionals, managers and policymakers.
Gathers together the latest research and developments in the field from journal articles and conference proceedings
Discusses and evaluates the most economical and low cost treatment technologies
Presents information from related fields on the applicability, strengths and weaknesses of particular nanomaterials in key applications, thus allowing for the continuation and expansion of research in a range of fields
Описание: Presents the latest research-based material on the use of progressive nanotechnologies for water technologies. Featuring coverage on relevant topics such as water purification, nano-metal oxides, chitosan nanoparticles, and contaminated waste water, this is an ideal reference source for engineers, students, academics, and researchers.
Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.
Автор: Adejare, Adeboye Название: Drug Discovery Approaches for the Treatment of Neurodegenerative ISBN: 0128028106 ISBN-13(EAN): 9780128028100 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer's Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer's Disease and illustrating the paradigm necessary to ensure future research and treatment success.
The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer's Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer's Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders.
Описание: Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies.
Описание: Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar- macological treatment is currently available.
Описание: An overview of the latest advances in the synthesis, characterization and applications of dendrimers and other complex dendritic architectures.
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