Drug Discovery Targeting Drug-Resistant Bacteria, Kesharwani, Prashant

Автор: Yinduo Ji
Название: Methicillin-Resistant Staphylococcus Aureus (MRSA) Protocols
ISBN: 1493960563 ISBN-13(EAN): 9781493960569
Издательство: Springer
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Цена: 16769.00 р.
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Описание:

1. Clinical, Epidemiologic, and Laboratory Aspects of Methicillin-Resistant Staphylococcus aureus Infections

Elizabeth Palavecino

2. Community-Associated Methicillin Resistant Staphylococcus aureus Case Studies

Madeleine G. Sowash and Anne-Catrin Uhlemann

3. Rapid Methods for Detection of MRSA in Clinical Specimens

Elizabeth Palavecino

4. Immunofluorescence Microscopy for the Detection of Surface Antigens in Methicillin Resistant Staphylococcus aureus (MRSA)

Yekaterina Timofeyeva, Ingrid L. Scully, and Annaliesa S. Anderson

5. Internal Transcribed Spacer (ITS)-PCR Identification of MRSA

Shin-ichi Fujita

6. Pulsed-Field Gel Electrophoresis Typing of Staphylococcus aureus Isolates

Yiping He, Yanping Xie, and Sue Reed

7. Multilocus Sequence Typing (MLST) of Staphylococcus aureus

Nicholas A. Saunders and Anne Holmes

8. Staphylococcal Cassette Chromosome mec (SCCmec) Analysis of MRSA

Teruyo Ito, Kyoko Kuwahara, Yuki Katayama, Yuki Uehara, Xiao Han, Yoko Kondo, and Keiichi Hiramatsu

9. Genetic Interruption of Target Genes for Investigation of Virulence Factors

Adhar C. Manna

10. Molecular Analysis of Staphylococcal Superantigens

Wilmara Salgado-Pabуn, Laura C. Case-Cook, and Patrick M. Schlievert

11. Investigation of Staphylococcus aureus Adhesion and Invasion of Host Cells

Junshu Yang and Yinduo Ji

12. Investigation of Biofilm Formation in Clinical Isolates of Staphylococcus aureus

James E. Cassat, Mark S. Smeltzer, and Chia Y. Lee

13. Transcriptomic Analysis of Staphylococcus aureus Using Microarray and Advanced Next-Generation RNA-seq Technologies

Ting Lei, Aaron Becker, and Yinduo Ji

14. Proteomic Approach to Investigate Pathogenicity and Metabolism of Methicillin-Resistant Staphylococcus aureus

Patrice Franзois, Alexander Scherl, Denis Hochstrasser, and Jacques Schrenzel

15. Metobolomic Investigation of Methicillin Resistant Staphylococcus aureus

Ting Lei, Lei Wang, Chi Chen, and Yinduo Ji

16. Treatment of Infections Due to Resistant Staphylococcus aureus

Gregory M. Anstead, Jose Cadena, and Heta Javeri

17. Anti-Infective Drug Development for MRSA

Anu Daniel

18. Animal Models in Drug Development for MRSA

Andrea Marra

Автор: Trabocchi
Название: Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology
ISBN: 1118145658 ISBN-13(EAN): 9781118145654
Издательство: Wiley
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Цена: 22168.00 р.
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Описание: This book reviews diversity-oriented synthesis (DOS), a leading and dynamic area in organic chemistry and drug discovery. It first covers key chemical methods for the generation of small molecules according to DOS principles as well as important classes of molecules generated through DOS approaches.

Автор: Sandhya Kortagere
Название: In Silico Models for Drug Discovery
ISBN: 1627033416 ISBN-13(EAN): 9781627033411
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This Methods in Molecular Biology (TM) book surveys in silico models, offering techniques to derive novel antimicrobial targets and methods for computing binding energies of drugs to their target proteins, plus protocols, materials lists, known pitfalls and more.

Автор: Vardanyan, Ruben (university Of Arizona, Tucson, A
Название: Piperidine-based drug discovery
ISBN: 0128051574 ISBN-13(EAN): 9780128051573
Издательство: Elsevier Science
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Цена: 16666.00 р.
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Описание:

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives.

Автор: Tagelsir Mohamed Gasmelseid
Название: Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications
ISBN: 1466603097 ISBN-13(EAN): 9781466603097
Издательство: Mare Nostrum (Eurospan)
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Цена: 35759.00 р.
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Описание: <em>Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications</em> offers the latest the field has to offer to practitioners and academics alike, presented through theoretical frameworks, case studies, and future directions. This vital resource gathers an integrated pattern of high quality publications from around the world providing current, current edge and provocative scientific work in the three domains of pharmacoinformatics: decision making domains, knowledge utilisation and representation environment, and the technological and infrastructural context.

Автор: Speck-Planche, Alejandro
Название: Multi-Scale Approaches in Drug Discovery
ISBN: 0081011296 ISBN-13(EAN): 9780081011294
Издательство: Elsevier Science
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Цена: 27791.00 р.
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Описание:

Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.

Автор: Bueno, Juan
Название: Molecular Evolutionary Models In Drug Discovery
ISBN: 012817613X ISBN-13(EAN): 9780128176139
Издательство: Elsevier Science
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Цена: 19875.00 р.
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Автор: Brenneman Jehrod, Iyer Malliga R.
Название: Anti-Fibrotic Drug Discovery
ISBN: 178801510X ISBN-13(EAN): 9781788015103
Издательство: Royal Society of Chemistry
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Цена: 35693.00 р.
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Описание: Anti-fibrotic Drug Discovery is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

Автор: Mark von Itzstein
Название: Influenza Virus Sialidase - A Drug Discovery Target
ISBN: 3034807791 ISBN-13(EAN): 9783034807791
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented.

Автор: Burnett Ned
Название: Encyclopedia of Drug Discovery and Development: Volume IV (Novel Technologies and Drug Development)
ISBN: 1632421399 ISBN-13(EAN): 9781632421395
Издательство: Неизвестно
Цена: 24783.00 р.
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Автор: Burnett Ned
Название: Current Progress in Drug Discovery and Development
ISBN: 1632415429 ISBN-13(EAN): 9781632415424
Издательство: Неизвестно
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Цена: 24140.00 р.
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Описание: Drug discovery is a significant part of medicine, pharmacology and biotechnology, which is concerned with the discovery of new and improved drugs. The process involves high-throughput screening (HTS), which refers to the testing of chemicals for their ability to modify the target. Other methods of drug discovery include de novo drug design, fragment-based lead discovery and protein-directed dynamic combinatorial chemistry. Drug development is the process of launching new drugs into the market after the lead compounds are identified during the drug discovery process. This stage involves two processes namely, pre-clinical development and clinical phase. Drug development ensures that all parameters of safety, pharmacokinetics, metabolism and toxicity of the new drug are analyzed prior to clinical trials. This book presents researches and studies performed by experts across the globe in the fields of drug discovery and drug development. A number of latest researches have been included to keep the readers up-to-date with the global concepts in these areas of study.

Автор: Loging
Название: Bioinformatics and Computational Biology in Drug Discovery and Development
ISBN: 0521768004 ISBN-13(EAN): 9780521768009
Издательство: Cambridge Academ
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Цена: 9186.00 р.
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Описание: Providing a comprehensive overview of the drug discovery and development pipeline, this book focuses on the integral role that computational biology methods play in this process. Covering technological advances and their relation to drug developmental processes, readers are exposed to new methods of discovery utilising the available technology.