Описание: The interest in ‘biomarkers’ seen across a spectrum of biomedical disciplines reflects the rise of molecular biology and genetics. A host of ‘omics’ disciplines in addition to genomics, marked by multidimensional data and complex analyses, and enabled by bioinformatics, have pushed the trajectory of biomarker development even further. They have also made more tractable the complex mappings of genotypes to phenotypes – genome-to-phenome mapping – to which the concept of a biomarker is central. Genomic investigations of the brain are beginning to reveal spectacular associations between genes and neural systems. Neural and cognitive phenomics are considered a necessary complement to genomics of the brain. Other major omics developments such as connectomics, the comprehensive mapping of neurons and neural networks, are heralding brain maps of unprecedented detail. Such developments are defining a new era of brain science. And in this new research environment, neural systems and cognitive operations are pressed for new kinds of definitions – that facilitate brain-behavioral alignment in an omics operating environment. This volume explores the topic of markers framed around the constructs of cognitive and neural systems. ‘Neurophenotype’ is a term adopted to describe a neural or cognitive marker that can be scientifically described within an associative framework – and while the genome-to-phenome framework is the most recognized of these, epigenetics and non-gene-regulated neural dynamics also suggest other frameworks. In either case, the term neurophenotype defines operational constructs of brain-behavioral domains that serve the integration of these domains with neuroscientific and omics models of the brain. The topic is critically important to psychiatry and neuropsychology: Neurophenotypes offer a ‘format’ and a ‘language’ by which psychiatry and neuropsychology can be in step with the brain sciences. They also bring a new challenge to the clinical neurosciences in terms of construct validation and refinement. Topics covered in the volume include: * Brain and cognition in the omics era * Phenomics, connectomics, and Research Domain Criteria * Circuit-based neurophenotypes, and complications posed by non-gene regulated factors * The legacy of the endophenotype concept – its utility and limitations * Various potential neurophenotypes of relevance to clinical neuroscience, including Response * Inhibition, Fear Conditioning and Extinction, Error Processing, Reward Dependence and Reward Deficiency, Face Perception, and Language Phenotypes * Dynamic (electrophysiological) and computational neurophenotypes * The challenge of a cultural shift for psychiatry and neuropsychology The volume may be especially relevant to researchers and clinical practitioners in psychiatry and neuropsychology and to cognitive neuroscientists interested in the intersection of neuroscience with genomics, phenomics and other omics disciplines.
Автор: Santangelo Susan Название: Second Honeymoons Can Be Murder ISBN: 0692530525 ISBN-13(EAN): 9780692530528 Издательство: Неизвестно Цена: 2240.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Santangelo Susan Название: Funerals Can Be Murder: Every Wife Has a Story ISBN: 0692244727 ISBN-13(EAN): 9780692244722 Издательство: Неизвестно Цена: 2240.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Like millions of other Baby Boomer couples, Carol and Jim Andrews are checking items off their To-Do list. First is Jim`s retirement, which Carol dreads more than a root canal without Novocain. Next is downsizing and moving. What they don`t expect are dead bodies to become part of their long-range plan.
Engaging important discussions about social conflict, environmental change, and imperialism in Africa, Different Shades of Green points to legacies of African environmental writing, often neglected as a result of critical perspectives shaped by dominant Western conceptions of nature and environmentalism. Drawing on an interdisciplinary framework employing postcolonial studies, political ecology, environmental history, and writing by African environmental activists, Byron Caminero-Santangelo emphasizes connections within African environmental literature, highlighting how African writers have challenged unjust, ecologically destructive forms of imperial development and resource extraction.
Different Shades of Green also brings into dialogue a wide range of African creative writing--including works by Chinua Achebe, Ngũgĩ wa Thiong'o, Bessie Head, Nadine Gordimer, Zakes Mda, Nuruddin Farah, Wangari Maathai, and Ken Saro-Wiwa--in order to explore vexing questions for those involved in the struggle for environmental justice, in the study of political ecology, and in the environmental humanities, urging continued imaginative thinking in effecting a more equitable, sustain¬able future in Africa.
Автор: Santangelo Michael, Luna Jade Sol, Santangelo Dr Michael Название: 27 Stars: Discovering Your True Self with Asterian Astrology ISBN: 0615949304 ISBN-13(EAN): 9780615949307 Издательство: Неизвестно Цена: 2923.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Every so often, a book comes along with the power to change each and every reader. If you've ever fantasized about finding the Fountain of Youth, tapping into your potential, and eating well, your book has arrived. Written with passion, humor, common sense, and must-have information, Gina Santangelo - founder of Flow Pilates Centre, certified health & mindset coach, fitness expert, and Reiki practitioner - takes you on a journey to your very best self. We all want to effect a positive change in our lives... from what we purchase at the market to what we eat and feed our families, to disciplined, targeted workouts, to honoring our passions. But knowing how and where to start is dangerously overwhelming. So we place these desires on the back burner, remain in limbo, not really feeling or looking our best; not really living life to the fullest - while we hang on to habits that don't serve us well. We are constantly bombarded with fitness fads and wacky dietary advice... leaving us in the dark about what is right for us. Gina ends this madness With 30+ years dedicated to clean eating and fitness, she presents critical information, step-by-step instructions and answers, and always honors her readers as unique individuals. For Gina, organic eating isn't a passing phase. It's her passion and her life. Eat Clean, Live Free is a life guide. It will teach you how to eat clean, seasonal fare (with confidence), make informed choices, best move your body, and reclaim your energy and spirit. It will remind you that your mind, spirit, and body work in unison, and that nourishment, in every sense of the word, is key. In her original, refreshing, and entertaining manner, Gina delivers. You will learn all about:
Making easy changes and taking action, TODAY
Filling your grocery cart, pantry, and mouth with clean, organic eating
The very best foods you can put in your mouth
GMOs, gluten, soy, and superfoods
current controversies and misconceptions about foods and additives
What's really going on with processed foods
The dangers hidden in labels
The most hazardous choices in restaurants and supermarkets
Cravings, portions, and tricks-of-the-trade
how to create a beautiful plate
the workout routines that "work" and those that age you (yes, really )
Detoxing (the mind and body)
Silent inflammation, lymph and longevity
Why you must feed your mind as well as your body
Holistic, natural customs to enrich each day
Achieving a fitter, stronger body
Replenishing your skin
How to grow young again
...and this is just for starters. Gina introduces her concept of Mindfields aka personal roadblocks, fears, and challenges that can come out of nowhere and stop us in our tracks. We've all got them; it's what we do with them that allows us to move forward... or not. And 5 To Thrive - the life-changing steps we can all take to live more fully and positively, the very steps that helped Gina through her own devastating tragedy, with body/mind balance and focus. Eat Clean, Live Free is more than a delightful guide to clean eating, beauty and youthful energy (though it most definitely delivers there); it is quite literally a lantern for the spirit. Because at the end of the day - and the beginning - it's what you eat in combination with how you think and live that ultimately sets you free. If you are a woman between the ages 35 and 105, you will identify with this book. But even more important... You will learn a lot. You will find answers you have been searching for. And last but not the least, you will know how to eat better, live better, embrace health and freedom, and greet each day with a renewed spirit. For anyone who wants to eat optimally and live a healthier life... you know, tap into your real potential... this is a gem.
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