Glutathione, 

Автор: H. Sies; A. Wendel
Название: Functions of Glutathione in Liver and Kidney
ISBN: 3642671349 ISBN-13(EAN): 9783642671340
Издательство: Springer
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Описание: The serene phrase, Lest I forget thee, glutathione ..., coined by the Kosowers (1) to describe the state in the 1960's, must be replaced now by something like "Inevitable GSH" in order to characterize the current situation. The surge in interest on the ubiquitous tripeptide has been ama- zing, with publications on GSH running at rates as high as one per day, so that it seemed appropriate to convene international experts for a discussion of recent develop- ments this year. Unlike the two previous meetings in this decade held in Tlibingen in 1973 (2) and in santa Ynez in 1975 (3), the scope was restricted to Functions of Gluta- thione in Liver and Kidney. Only in this way did an in-depth discussion of the current state of knowledge in a limit- ed topic appear possible. The last couple of years have seen a fascinating pro- ductivity in the fields of (a) Regulation of the Glutathione Level in the Liver, (b) Role of y-Glutamyltransferase in Gluta- thione Turnover with emphasis on the renal enzyme, and a critical appraisal of the y-Glutamyl Cycle, (c) Hyd: roperox- ide and Disulfide Metaholism, enriched by the discovery of the nonseleniurn-dependent glutathione peroxidase activ- ity and its relation to the glutathione-S-transferases, and the participation of the 2GSH/GSSG system in redox transitions in intact organ, cells and isolated mito- chondria, and (d) a multitude of Pharmacological and Toxi- cological Aspects related to glutathione, mainly centered on the events leading to liver damage and the protective

Автор: Mohammad Anwar Hossain; Mohammad Golam Mostofa; Pe
Название: Glutathione in Plant Growth, Development, and Stress Tolerance
ISBN: 3319666819 ISBN-13(EAN): 9783319666815
Издательство: Springer
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Цена: 23757.00 р.
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Описание:

Glutathione (γ-glutamyl-cysteinyl-glycine) is a ubiquitously distributed sulfurcontaining antioxidant molecule that plays key roles in the regulation of plant growth, development, and abiotic and biotic stress tolerance. It is one of the most powerful low-molecular-weight thiols, which rapidly accumulates in plant cells under stress. Recent in-depth studies on glutathione homeostasis (biosynthesis, degradation, compartmentalization, transport, and redox turnover) and the roles of glutathione in cell proliferation and environmental stress tolerance have provided new insights for plant biologists to conduct research aimed at deciphering the mechanisms associated with glutathione-mediated plant growth and stress responses, as well as to develop stress-tolerant crop plants. Glutathione has also been suggested to be a potential regulator of epigenetic modifications, playing important roles in the regulation of genes involved in the responses of plants to changing environments. The dynamic relationship between reduced glutathione (GSH) and reactive oxygen species (ROS) has been well documented, and glutathione has been shown to participate in several cell signaling and metabolic processes, involving the synthesis of protein, the transport of amino acids, DNA repair, the control of cell division, and programmed cell death. Two genes, gamma-glutamylcysteine synthetase (GSH1) and glutathione synthetase (GSH2), are involved in GSH synthesis, and genetic manipulation of these genes can modulate cellular glutathione levels. Any fluctuations in cellular GSH and oxidized glutathione (GSSG) levels have profound effects on plant growth and development, as glutathione is associated with the regulation of the cell cycle, redox signaling, enzymatic activities, defense gene expression, systemic acquired resistance, xenobiotic detoxification, and biological nitrogen fixation. Being a major constituent of the glyoxalase system and ascorbate-glutathione cycle, GSH helps to control multiple abiotic and biotic stress signaling pathways through the regulation of ROS and methylglyoxal (MG) levels. In addition, glutathione metabolism has the potential to be genetically or biochemically manipulated to develop stress-tolerant and nutritionally improved crop plants. Although significant progress has been made in investigating the multiple roles of glutathione in abiotic and biotic stress tolerance, many aspects of glutathione-mediated stress responses require additional research.

The main objective of this volume is to explore the diverse roles of glutathione in plants by providing basic, comprehensive, and in-depth molecular information for advanced students, scholars, teachers, and scientists interested in or already engaged in research that involves glutathione. Finally, this book will be a valuable resource for future glutathione-related research and can be considered as a textbook for graduate students and as a reference book for frontline researchers working on glutathione metabolism in relation to plant growth, development, stress responses, and stress tolerance.

Автор: Vina
Название: Revival: Glutathione (1990)
ISBN: 1138558931 ISBN-13(EAN): 9781138558939
Издательство: Taylor&Francis
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Цена: 16843.00 р.
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Описание: This work focuses on the synthesis-degradation and oxidation-reduction cycles of glutathione, the physiological functions of glutathione (especially in mammalian cells), and the analytical methods used to accurately measure the glutathione status of cells.

Название: Glutathione In The Nervous System
ISBN: 0367447886 ISBN-13(EAN): 9780367447885
Издательство: Taylor&Francis
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Цена: 9492.00 р.
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Описание: This book focuses on the origin of GSH in the nervous system, the effects of GSH on neural health and activity, and the potential for alterations in GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson`s disease, and other neurological disorders.

Название: Toxicology of Glutathione Transferases
ISBN: 0367390531 ISBN-13(EAN): 9780367390532
Издательство: Taylor&Francis
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Цена: 9798.00 р.
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Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in all areas of GST research and have actively contributed to the progress of this field, the book describes the role of GSTs in toxicology, focusing on their pharmacologic and physiologic roles and their relevance to biological toxicology.

The book provides current information on gene families, structure and regulation of gene expression, reaction mechanisms and substrates, three-dimensional structures of GSTs, design of proteins with GST activity, and various approaches to developing inhibitors that overcome drug resistance. It also covers the physiological significance and the mechanisms of activation of microsomal GSTs. These topics, along with the role of GSTs in detoxification of chemical carcinogens and possible implications of GST polymorphism in human health and disease, make the volume useful to researchers in the field of pharmacology and toxicology.

Chapters cover the possible and exciting role of GSTs in defense mechanisms against chronic oxidative stress-linked disorders such as atherosclerosis and the newly emerging area of GST-mediated modulation of stress-signaling through its catalytic as well as binding activities. They explore an intriguing hypothesis that strongly suggests an important role of the factors that modulate the GSH-electrophile conjugate (GS-E) homeostasis in the regulation of cellular processes. Chapters on known and potential endogenous electrophilic substrates and a major role of GSTs in suppressing stress-induced lipid peroxidation reinforce this newly emerging role of GSTs. These are just a few of the features that make the book helpful to clinicians involved in basic as well as tr

Автор: Vina
Название: Glutathione (1990)
ISBN: 1138105643 ISBN-13(EAN): 9781138105645
Издательство: Taylor&Francis
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Цена: 65076.00 р.
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Описание: The aim of this important book is to present the reader with developments concerning glutathione research

Автор: Mohammad Anwar Hossain; Mohammad Golam Mostofa; Pe
Название: Glutathione in Plant Growth, Development, and Stress Tolerance
ISBN: 3319883003 ISBN-13(EAN): 9783319883007
Издательство: Springer
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Цена: 20962.00 р.
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Описание: International experts contribute to state-of-the-art studies on glutathione metabolismIn-depth discussion on the mechanisms of glutathione-mediated physiological responses in plants
Comprehensive reviews on the biochemical and molecular pathways of stress tolerance