Therapeutic Oligonucleotides: Methods and Protocols, Goodchild John
Автор: Satoshi Obika; Mitsuo Sekine Название: Synthesis of Therapeutic Oligonucleotides ISBN: 9811319111 ISBN-13(EAN): 9789811319112 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Поставка под заказ.
Описание:
This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.
Автор: Claude Malvy; Annick Harel-Bellan; Linda L. Pritch Название: Triple Helix Forming Oligonucleotides ISBN: 1461373581 ISBN-13(EAN): 9781461373582 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene.
Описание: Aptly named `Television`s First Lady` by Walter Ames of the Los Angeles Times, actress Beverly Garland (1926-2008) is also regarded as a Western and science-fiction film icon. In addition to more than 700 TV appearances, she made more than 55 feature and made-for-television films. This comprehensive biography includes a foreword and afterword by her colleagues Joseph Campanella and Peggy Webber.
Автор: Smales C. Mark, James David C. Название: Therapeutic Proteins / Methods and Protocols ISBN: 1588293904 ISBN-13(EAN): 9781588293909 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: World-class researchers share their innovative and proven techniques for the production of therapeutic proteins downstream of the discovery stage. The methods use a variety of sources for producing therapeutic proteins, including bacterial and yeast expression systems, and insect and mammalian cells, and then cover the purification of the resulting protein using both state-of-the-art and traditional methods, such as those sourced from plasma. Additional chapters offer methods for the characterization of therapeutic proteins throughout the production process, along with methods and strategies for viral inactivation and protein formulation. The protocols follow the successful Methods in Molecular Biologyв„ў series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
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