The Biochemistry of Retinoid Signaling II: The Physiology of Vitamin a - Uptake, Transport, Metabolism and Signaling, Asson-Batres Mary Ann, Rochette-Egly Cecile
Автор: Mary Ann Asson-Batres; Cecile Rochette-Egly Название: The Biochemistry of Retinoid Signaling II ISBN: 9402409432 ISBN-13(EAN): 9789402409437 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area.
In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases.
Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Автор: Pohl, Ehmke Название: Retinoid Signaling Pathways,637 ISBN: 0128201444 ISBN-13(EAN): 9780128201442 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more.
Provides the authority and expertise of leading contributors from an international board of authors
Presents the latest release in the Methods in Enzymology series
Includes the latest information on retinoid signaling pathways
Автор: Swapan K. Ray Название: Retinoid and Rexinoid Signaling ISBN: 1493995847 ISBN-13(EAN): 9781493995844 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Поставка под заказ.
Описание: This volume explores the latest synthetic procedures for producing receptor-specific retinoids and rexinoids, molecular biology methods, and new technologies to demonstrate the therapeutic activities of molecules. The chapters in this book cover topics such as lentiviral delivery of shRNA constructs into acute promyelocytic leukemia cells for ATRA induced differentiation and autophagy; methods to analyze RAR signaling in colorectal cancer cells; differentiation of primary myoblasts by using RXR agonist; methodology for analyzing effects of retinoid treatment on nervous system development and larval swimming behavior; and protocols for assessment of autophagic flux in ATRA treated 2D and 3D breast cancer cultures. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Retinoid and Rexinoid Signaling: Methods and Protocols is a valuable resources for graduate students, postdoctoral fellows, and principal investigators who are interested in further exploring the signaling mechanisms of these molecules in their specific preclinical models.
Описание: This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer.
Описание: Since the first international meeting on Vitamin B6 involvement in catalysis took place in 1962, there have been periodic meetings every three or four years.
Автор: G. Marino; G. Sannia; F. Bossa Название: Biochemistry of Vitamin B6 and PQQ ISBN: 3034873956 ISBN-13(EAN): 9783034873956 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Intemational Meeting on Vitamin B6 and Carbonyl Catalysis took place on Capri, Italy from 22nd to 27th May 1994 and was organized in conjunction with the 3rd Symposium on PQQ and Quinoproteins.
Автор: P. Christen; Korpela Название: Biochemistry of Vitamin B6 ISBN: 3034899890 ISBN-13(EAN): 9783034899895 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The ecent Vitamin Be-Meeting in Tu ku, FinLand, has continued a Long-standing t1'O.dition; it ws the seventh intemationaL congNss devoted to the "ChemicaL and BioLogicaL Aspects of Vitamin Be-Cata- Lysis". The fi st meeting ws heLd 1962 in Rome foUo1JJed by the meetings in Moscow (1966), Nagoya (1967), Lening1'O.d (1974), To onto (1979), and Athens (1983). The p oceedings of a meeting p ovide a "snapshot" of a pa ticuLa fieLd of science. Not unLike the photog phic p oduct they affo d a topicaL eco of the goings-on, at pe haps the expense of some inforrmation on detaUs. These Proceedings focus on the st uctu L and mechanistic aspects of vitamin B6-dependent enaymes; h01JJeve, othe topics discussed nge f om nonenaymic eactions of vitamin B6 compounds to nut tionaL, medicaL, and even appLied indust aL as- pects. The Opening Session of the Meeting ws dedicated to the memo y of the Late ALe: x: ande E. B unstein, who fifty yea s ago discove ed t nsamination as a metaboUc eaction. The contT'ibutions honoT'ing P ofesso B unstein and his Ufewo k a e coUected in the fi st section of the oceedings.
Название: Essential guide to vitamin d ISBN: 1536166006 ISBN-13(EAN): 9781536166002 Издательство: Nova Science Рейтинг: Цена: 13462.00 р. Наличие на складе: Невозможна поставка.
Описание: This guide first discusses vitamin D receptor, a member of the superfamily of nuclear steroid/thyroid hormone receptors that can be found in both the cytoplasm and nucleus. It acts mainly as a ligand-dependent DNA-binding transcriptional factor mediating the actions of the biological active form of vitamin D (VD), the metabolite 1I±,25[OH]2D3. Vitamin D has a complex role in the human body. Beside the classical effects in bone mineralisation, a significant amount of data regarding the role of this vitamin in cell differentiation, defence mechanism, allergy, inflammation, metabolism and hormonal regulation continue to accumulate. As such, the relevance of these effects for lung disorders is under investigation. Vitamin D is a hormone with pleiotropic effects; it controls calcium homeostasis, immune response, and hemodynamic wall stress. In the last decade, numerous studies have focused on the role of vitamin D levels in cardiovascular disease. In particular, it has been shown that insufficient Vitamin D levels are frequently observed among patients with cardiovascular disease. Additionally, calcitriol, which is also called 1, 25-dihydroxy vitamin D3, is involved in several physiological processes maintaining balanced bone turnover and a healthy bone microenvironment. The beneficial effects of vitamin D on bone biomechanical features are not exclusively attributable to the reduction in non-mineralised bone matrix, but to the osteocyte number and their connectivity, too. Studies have reported that Vitamin D is essential for recovery of hospitalised patients as they are at increased risk of developing/worsening vitamin D deficiency due to lack of availability of sources of the vitamin. Various cognitive disorders have also been associated with hypovitaminosis D. Vitamin D has also been proposed as a risk-modifying factor for many chronic diseases, including multiple sclerosis, schizophrenia, cognitive issues, hypertension, heart disease, diabetes, cancer, psoriasis, and other autoimmune diseases. Vitamin D deficiency is the main cause of osteoporosis and osteomalacia in adults and rickets in children. The low serum of this vitamin is common in patients suffering from cardiovascular, autoimmune, cancer, psoriasis, depression and atherosclerosis disorder. The highly sensitive nature of vitamin D to environmental factors including light, heat, and oxygen, as well as hydrophobicity and acid labile nature, are the major drawbacks that need to be addressed for development of an efficient formulation for vitamin D.
Описание: Presents information on proteins dependent upon Vitamin B6, PQQ or other quinones for function. This work contains sections focusing on the mechanisms of folding and addressing the molecular physiology and pathology of these families of proteins, which are of biomedical interest.
Название: Tocotrienols Vitamin E Beyond Tocop ISBN: 1138199729 ISBN-13(EAN): 9781138199729 Издательство: Taylor&Francis Рейтинг: Цена: 12707.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters.
Highlights
Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer
Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health
Tocopherol interference with tocotrienol functions
All new chapters and many new contributors
Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies.
Dr. Tan discusses the benefits of tocotrienol in a YouTube video.
Автор: Mato Название: Phospholipid Metabolism in Cellular Signaling ISBN: 1315896427 ISBN-13(EAN): 9781315896427 Издательство: Taylor&Francis Рейтинг: Цена: 14545.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Phospholipids are no longer considered exclusively as the building blocks of biomembranes, but are now regarded to be exceptionally important to cellular signalling.
Автор: Da-Peng Zhang Название: Abscisic Acid: Metabolism, Transport and Signaling ISBN: 9401794235 ISBN-13(EAN): 9789401794237 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive review of all aspects of the molecular and cell biology of abscisic acid (ABA) metabolism, transport and signal transduction, covering our current understanding of ABA as well as research trends. The agricultural significance of ABA metabolism, transport and signal transduction is also discussed. The phytohormone ABA regulates many aspects of plant development and plays a central role in plant adaptation to environmental stresses. Over the past few decades, considerable advances have been made in the study of ABA metabolism, transport and signal transduction, greatly deepening our understanding of the underlying mechanisms of ABA function at the molecular, cell and whole-plant level and helping us improve crops’ environmental tolerance. This book provides a valuable resource for researchers and advanced students interested in plant biology and agriculture.
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