Mitochondrial Gene Expression: Methods and Protocols, Minczuk Michal, Rorbach Joanna

Автор: Gabriel D. Dakubo
Название: Mitochondrial Genetics and Cancer
ISBN: 3642114156 ISBN-13(EAN): 9783642114151
Издательство: Springer
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Цена: 28734.00 р.
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Описание: This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. It focuses on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways.

Автор: Patrick Lestienne
Название: Mitochondrial Diseases
ISBN: 3642641660 ISBN-13(EAN): 9783642641664
Издательство: Springer
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Описание: For those like me who witnessed the beginning of the adventure of human mitochon- drial pathology, one can only be astounded by the extent and unexpectedness of what the field has come to offer. Extent because nobody could have imagined the sheer size of the domain. Unexpectedness because hitherto it was impossible to imagine the clinical polymorphism that this pathology would represent. The starting point was clear. Initially, there was the exceptional, and for a long time unique, observation of euthyroidian hypermetabolism that Luft and colleagues analyzed remarkably in biochemical and clinical terms. Thereafter, there was the support provided by the electron microscopy studies of Afzelius, and the very first visualization of mitochondrial abnormalities. That was way back in 1958. A few years later, progress in the cytology and cytochemistry of skeletal muscle tissue was to provide the means of detecting such abnormalities by examining sections with light microscopy. The colorful term "ragged red fibers", coined by W. K. Engel, became uni- versally accepted, and this typical aspect with Gomori trichrome stain was to throw light on the frequency with which these mitochondrial abnormalities could occur under pathological conditions which, until then, had remained a total mystery regard- ing their mechanism: syndromes such as the ocular myopathies with their descending evolution and the oculocraniosomatic syndromes. We were at the beginning of the 1970s.

Название: Mitochondrial disorders caused by nuclear genes
ISBN: 1489992413 ISBN-13(EAN): 9781489992413
Издательство: Springer
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Описание: This book surveys mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation, covering the biochemical, molecular, clinical, and genetic aspects of syndromes and heterogeneous mitochondrial disease caused by specific genes.

Автор: Keshav K. Singh
Название: Mitochondrial DNA Mutations in Aging, Disease and Cancer
ISBN: 3662125110 ISBN-13(EAN): 9783662125113
Издательство: Springer
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Цена: 16979.00 р.
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Описание: Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson`s, Alzheimer`s, and Huntington`s diseases.

Автор: Gabriel D. Dakubo
Название: Mitochondrial Genetics and Cancer
ISBN: 3642424619 ISBN-13(EAN): 9783642424618
Издательство: Springer
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Цена: 28732.00 р.
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Описание: This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. It focuses on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways.

Автор: Hongzhi Sun; Xiangdong Wang
Название: Mitochondrial DNA and Diseases
ISBN: 9811349290 ISBN-13(EAN): 9789811349294
Издательство: Springer
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Цена: 20962.00 р.
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Описание: The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.

Автор: Matthew McKenzie
Название: Mitochondrial DNA
ISBN: 1493949446 ISBN-13(EAN): 9781493949441
Издательство: Springer
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Цена: 13974.00 р.
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Описание:

Part I: Detection of Mitochondrial DNA Mutations and Mitochondrial DNA Damage

1. Comprehensive Mitochondrial Genome Analysis By Massively Parallel Sequencing

Meagan E. Palculict, Victor Wei Zhang, Lee-Jun Wong, and Jing Wang

2. Analysis Of Translesion DNA Synthesis By The Mitochondrial DNA Polymerase g

William C. Copeland, Rajesh Kasiviswanathan, and Matthew J. Longley

3. Quantification Of DNA Damage By Real-Time Qpcr

Wei Wang, Katja Scheffler, Ying Esbensen, And Lars Eide

4. Quantitation Of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single Molecule

Автор: Dimond, Rebecca Stephens, Neil
Название: Legalising mitochondrial donation
ISBN: 3319746448 ISBN-13(EAN): 9783319746449
Издательство: Springer
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Описание: They draw on stakeholder accounts and public documents to explore how patients, professionals, institutions and publics mobilised within `for` and `against` clusters, engaging in extensive promissory, emotional, bureaucratic, ethical, embodied and clinical labour to justify competing visions of an ethical future.

Автор: Bernhard Kadenbach
Название: Mitochondrial Oxidative Phosphorylation
ISBN: 1493901567 ISBN-13(EAN): 9781493901562
Издательство: Springer
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Описание: This book describes the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation, showing how most of these occur in eukaryotic cells, but not in bacteria or archaea. Coverage includes mitochondrial genes and human disease.