Mitochondrial DNA and Diseases, Hongzhi Sun; Xiangdong Wang

Автор: Patrick Lestienne
Название: Mitochondrial Diseases
ISBN: 3642641660 ISBN-13(EAN): 9783642641664
Издательство: Springer
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Описание: For those like me who witnessed the beginning of the adventure of human mitochon- drial pathology, one can only be astounded by the extent and unexpectedness of what the field has come to offer. Extent because nobody could have imagined the sheer size of the domain. Unexpectedness because hitherto it was impossible to imagine the clinical polymorphism that this pathology would represent. The starting point was clear. Initially, there was the exceptional, and for a long time unique, observation of euthyroidian hypermetabolism that Luft and colleagues analyzed remarkably in biochemical and clinical terms. Thereafter, there was the support provided by the electron microscopy studies of Afzelius, and the very first visualization of mitochondrial abnormalities. That was way back in 1958. A few years later, progress in the cytology and cytochemistry of skeletal muscle tissue was to provide the means of detecting such abnormalities by examining sections with light microscopy. The colorful term "ragged red fibers", coined by W. K. Engel, became uni- versally accepted, and this typical aspect with Gomori trichrome stain was to throw light on the frequency with which these mitochondrial abnormalities could occur under pathological conditions which, until then, had remained a total mystery regard- ing their mechanism: syndromes such as the ocular myopathies with their descending evolution and the oculocraniosomatic syndromes. We were at the beginning of the 1970s.

Автор: Carlos M. Palmeira; Ant?nio J. Moreno
Название: Mitochondrial Bioenergetics
ISBN: 1493992988 ISBN-13(EAN): 9781493992980
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This second edition volume expands on the previous edition with chapters discussing the latest developments and research initiatives in mitochondrial functions. The chapters in this book explore topics such as high-resolution fluorespirometry and OXPHOS protocols in human cells, analysis of mitochondrial oxygen consumption, mitochondrial bioenergetics, and mitochondrial dynamics in mammalian cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Mitochondrial Bioenergetics: Methods and Protocols, Second Edition is a valuable resource for students, and practitioners in the pharmaceutical sciences, environmental sciences, and mitochondrial genetics industries.

Автор: Orrenius
Название: Mitochondrial Signaling in Health and Disease
ISBN: 1439880026 ISBN-13(EAN): 9781439880029
Издательство: Taylor&Francis
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Описание:

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.

Автор: Keshav K. Singh
Название: Mitochondrial DNA Mutations in Aging, Disease and Cancer
ISBN: 3662125110 ISBN-13(EAN): 9783662125113
Издательство: Springer
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Цена: 16979.00 р.
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Описание: Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson`s, Alzheimer`s, and Huntington`s diseases.

Автор: Justin C. St. John
Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells
ISBN: 1627038671 ISBN-13(EAN): 9781627038676
Издательство: Springer
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Цена: 22201.00 р.
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Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.

Автор: Matthew McKenzie
Название: Mitochondrial DNA
ISBN: 1493949446 ISBN-13(EAN): 9781493949441
Издательство: Springer
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Цена: 13974.00 р.
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Описание:

Part I: Detection of Mitochondrial DNA Mutations and Mitochondrial DNA Damage

1. Comprehensive Mitochondrial Genome Analysis By Massively Parallel Sequencing

Meagan E. Palculict, Victor Wei Zhang, Lee-Jun Wong, and Jing Wang

2. Analysis Of Translesion DNA Synthesis By The Mitochondrial DNA Polymerase g

William C. Copeland, Rajesh Kasiviswanathan, and Matthew J. Longley

3. Quantification Of DNA Damage By Real-Time Qpcr

Wei Wang, Katja Scheffler, Ying Esbensen, And Lars Eide

4. Quantitation Of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single Molecule

Автор: Lee-Jun C. Wong
Название: Mitochondrial Disorders
ISBN: 1493959506 ISBN-13(EAN): 9781493959501
Издательство: Springer
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Цена: 20263.00 р.
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Описание: The variability of clinical symptoms in mitochondrial diseases calls for a systematic presentation of the full range of protocols used in their assessment. This volume provides cutting-edge methods of analysis as well as expert guidance on how to apply them.

Автор: Volkmar Weissig; Marvin Edeas
Название: Mitochondrial Medicine
ISBN: 1493922874 ISBN-13(EAN): 9781493922871
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction.

Автор: Gaetano Santulli
Название: Mitochondrial Dynamics in Cardiovascular Medicine
ISBN: 3319856308 ISBN-13(EAN): 9783319856308
Издательство: Springer
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Цена: 25155.00 р.
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Описание: This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Автор: Gaetano Santulli
Название: Mitochondrial Dynamics in Cardiovascular Medicine
ISBN: 3319553291 ISBN-13(EAN): 9783319553290
Издательство: Springer
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Цена: 32142.00 р.
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Описание: Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.