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Jak-Stat Signalling: Methods and Protocols, Nicholson Sandra E., Nicola Nicos A.


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Автор: Nicholson Sandra E., Nicola Nicos A.
Название:  Jak-Stat Signalling: Methods and Protocols
ISBN: 9781493959792
Издательство: Springer
Классификация:



ISBN-10: 1493959794
Обложка/Формат: Paperback
Страницы: 320
Вес: 0.58 кг.
Дата издания: 23.08.2016
Серия: Methods in molecular biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 12 tables, black and white; xi, 320 p.
Размер: 25.40 x 17.78 x 1.78 cm
Читательская аудитория: General (us: trade)
Подзаголовок: Methods and protocols
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: The receptor-associated JAK protein kinases and their substrates, the STAT transcriptional activators, transmit signals following cytokine and growth factor binding to receptors expressed on the cell surface, to result in specific transcriptional and cellular responses. Over the last two decades, the field has progressed from identification of the individual components through to an understanding of the activation and deactivation mechanisms, and the complex structural detail of the proteins involved. We now know that these pathways are important in many biological processes, including growth and development, hematopoiesis, and the innate and adaptive immune response. JAK-STAT Signalling: Methods and Protocols provides detailed methodologies for examining many aspects of the pathway. Divided into four sections, topics include JAK and STAT specific approaches, the negative regulators of the pathway (SOCS proteins), and the production and crystallization of JAK and STAT proteins, among others. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, JAK-STAT Signalling: Methods and Protocols will be of use not only to those working in the area but also to new investigators who are led to delve into the complexities of JAK and STAT responses.
Дополнительное описание: Analysis of Janus Tyrosine Kinase Phosphorylation and Activation.- Co-Immunoprecipitation Protocol to Investigate Cytokine Receptor Associated Proteins e.g. Janus Kinases or Other Associated Signaling Proteins.- In Vitro JAK Kinase Activity and Inhibition



Molecular Beacons: Signalling Nucleic Acid Probes, Methods, and Protocols

Автор: Marx
Название: Molecular Beacons: Signalling Nucleic Acid Probes, Methods, and Protocols
ISBN: 1617377260 ISBN-13(EAN): 9781617377266
Издательство: Springer
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Цена: 18167.00 р.
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Описание: From probe design to applications in clinical settings, this book provides a diverse set of instructive examples, guided by experts in the field who offer easy-to-follow experimentals.

Models of Calcium Signalling

Автор: Dupont
Название: Models of Calcium Signalling
ISBN: 3319296450 ISBN-13(EAN): 9783319296456
Издательство: Springer
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Цена: 12577.00 р.
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Описание: This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism.Genevi?ve Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Universit? Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbr?ck Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.

Biophysical Basis of Physiology and Calcium Signalling Mechanism in Cardiac and Smooth Muscle

Автор: Watanabe, Tetsuya
Название: Biophysical Basis of Physiology and Calcium Signalling Mechanism in Cardiac and Smooth Muscle
ISBN: 0128149507 ISBN-13(EAN): 9780128149508
Издательство: Elsevier Science
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Цена: 19370.00 р.
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Описание:

Biophysical Basis of Physiology and Calcium Signaling Mechanism in Cardiac and Smooth Muscle acts as a bridge between physiology and physics by discussing the physiology and calcium signaling mechanism in cardiac and smooth muscle. By exploring the mechanism of the cyclic release of stored Ca (2+) in the SR or ER, this book covers the cell communication system, including excitable cells, recognizing the most relevant mechanisms of cell communication. Serving as a bridge between physiology and physics, coverage spans the physiology and calcium signaling mechanism in cardiac and smooth muscle, offering insight to physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists.

  • Explores the mechanism of the cyclic release of stored Ca 2+ in the SR or ER
  • Provides in-depth coverage of cell communication systems to explain the most relevant mechanisms of cell communication
  • Covers the physiology and calcium signaling mechanism in cardiac and smooth muscle
The Biochemistry of Cell Signalling

Автор: Helmreich, Ernst
Название: The Biochemistry of Cell Signalling
ISBN: 0198508204 ISBN-13(EAN): 9780198508205
Издательство: Oxford Academ
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Цена: 13464.00 р.
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Описание: 'The Biochemistry of Cell Signalling' is a comprehensive yet concise study of the principles of cell signalling, concentrating on the structural and mechanistic aspects.

Cell Signalling

Автор: Hancock
Название: Cell Signalling
ISBN: 0199232105 ISBN-13(EAN): 9780199232109
Издательство: Oxford Academ
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Цена: 5859.00 р.
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Описание: A carefully structured introduction to this intricate subject, Cell Signalling introduces those conserved features that underlie many different extra- and intracellular signalling systems. After exploring the key components of signalling mechanisms it goes on to examine how signalling pathways are constructed from those components.


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