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Nanoscale Imaging and Characterisation of Amyloid-β, Tinker-Mill Claire Louisa


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Автор: Tinker-Mill Claire Louisa
Название:  Nanoscale Imaging and Characterisation of Amyloid-β
ISBN: 9783319819075
Издательство: Springer
Классификация:






ISBN-10: 3319819070
Обложка/Формат: Paperback
Страницы: 149
Вес: 0.25 кг.
Дата издания: 07.06.2018
Серия: Springer theses
Язык: English
Издание: Softcover reprint of
Иллюстрации: 14 illustrations, color; 45 illustrations, black and white; xx, 149 p. 59 illus., 14 illus. in color.; 14 illustrations, color; 45 illustrations, blac
Размер: 23.39 x 15.60 x 0.94 cm
Читательская аудитория: General (us: trade)
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This thesis presents a method for reliably and robustly producing samples of amyloid-? (A?) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide’s nanomechanical, elastic, thermal or spectroscopical properties. Amyloid-? (A?) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of A? with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.
Дополнительное описание: Introduction.- Literature Review and Theoretical Concepts.- Experimental Methodology.- Substrate Development of the Imaging of Amyloid Proteins with SPM Methods.- Scanning Probe Microscopy Methods of Imaging Amyloid Peptides During the Aggregation Process



Characterisation Methods in Solid State and Materials Science

Автор: Morrison Kelly
Название: Characterisation Methods in Solid State and Materials Science
ISBN: 0750319143 ISBN-13(EAN): 9780750319140
Издательство: Неизвестно
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Цена: 6207.00 р.
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Characterisation of Turbulent Duct Flows: Experiments and Direct Numerical Simulations

Автор: Owolabi Bayode
Название: Characterisation of Turbulent Duct Flows: Experiments and Direct Numerical Simulations
ISBN: 3030197476 ISBN-13(EAN): 9783030197476
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Introduction.- Literature Review and background theory.- Experimental Methods.- Numerical Methods.- Turbulent Pressure-Driven Flow in a Square Duct at Low Reynolds Numbers.- Turbulent Wall-Driven Flows.- Turbulent Duct Flows with Polymer Additives.- Conclusions and Recommendations.

Particulate Materials: Synthesis, Characterisation, Processing And Modelling

Автор: Chuan-Yu Wu
Название: Particulate Materials: Synthesis, Characterisation, Processing And Modelling
ISBN: 184973366X ISBN-13(EAN): 9781849733663
Издательство: Royal Society of Chemistry
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Цена: 25333.00 р.
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Описание: This book contains a selection of papers discussing the state-of-the-art research in particulate materials science that were presented at the UK-China Particle Technology Forum III held at Birmingham, UK in 2011.

Nanoscale Imaging and Characterisation of Amyloid-?

Автор: Tinker-Mill
Название: Nanoscale Imaging and Characterisation of Amyloid-?
ISBN: 3319395335 ISBN-13(EAN): 9783319395333
Издательство: Springer
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Цена: 15372.00 р.
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Описание:

This thesis presents a method for reliably and robustly producing samples of amyloid-? (A?) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide’s nanomechanical, elastic, thermal or spectroscopical properties.
Amyloid-? (A?) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of A? with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.
Amyloid and Amyloidosis

Название: Amyloid and Amyloidosis
ISBN: 0367454254 ISBN-13(EAN): 9780367454258
Издательство: Taylor&Francis
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Цена: 9492.00 р.
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Описание: This authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, incl

Characterisation of Turbulent Duct Flows

Автор: Bayode Owolabi
Название: Characterisation of Turbulent Duct Flows
ISBN: 3030197441 ISBN-13(EAN): 9783030197445
Издательство: Springer
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Цена: 6986.00 р.
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Описание: This book presents several new findings in the field of turbulent duct flows, which are important for a range of industrial applications. It presents both high-quality experiments and cutting-edge numerical simulations, providing a level of insight and rigour rarely found in PhD theses. The scientific advancements concern the effect of the Earth’s rotation on large duct flows, the experimental confirmation of marginal turbulence in a pressure-driven square duct flow (previously only predicted in simulations), the identification of similar marginal turbulence in wall-driven flows using simulations (for the first time by any means) and, on a separate but related topic, a comprehensive experimental study on the phenomenon of drag reduction via polymer additives in turbulent duct flows. In turn, the work on drag reduction resulted in a correlation that provides a quantitative prediction of drag reduction based on a single, measurable material property of the polymer solution, regardless of the flow geometry or concentration. The first correlation of its kind, it represents an important advancement from both a scientific and practical perspective.

Computational Characterisation of Gold Nanocluster Structures

Автор: Andrew James Logsdail
Название: Computational Characterisation of Gold Nanocluster Structures
ISBN: 3319348655 ISBN-13(EAN): 9783319348650
Издательство: Springer
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Цена: 18284.00 р.
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Описание: This book presents a detailed analysis of structural preferences in monometallic and bimetallic gold nanoclusters. It characterizes the optical properties of gold-based bimetallic nanoparticles with varying morphologies.

Magneto-Active Polymers: Fabrication, characterisation, modelling and simulation at the micro- and macro-scale

Автор: Jean-Paul Pelteret, Paul Steinmann
Название: Magneto-Active Polymers: Fabrication, characterisation, modelling and simulation at the micro- and macro-scale
ISBN: 3110419513 ISBN-13(EAN): 9783110419511
Издательство: Walter de Gruyter
Цена: 22305.00 р.
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Описание: From fabrication to testing and modeling this monograph covers all aspects on the materials class of magneto active polymers. The focus is on computational modeling of manufacturing processes and material parameters. As other smart materials, these elastomers have the ability to change electrical and mechanical properties upon application of magnetic fields. This allows for novel applications ranging from biomedical engineering to mechatronics.

Cerebral Amyloid Angiopathy in Alzheimer`s Disease and Related Disorders

Автор: M.M. Verbeek; R.M. de Waal; Harry V. Vinters
Название: Cerebral Amyloid Angiopathy in Alzheimer`s Disease and Related Disorders
ISBN: 0792363663 ISBN-13(EAN): 9780792363668
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Examines the phenomenon of cerebral amyloid angiopathy (CAA) using a multifaceted approach. This book examines various questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations.

Computational Characterisation of Gold Nanocluster Structures

Автор: Andrew James Logsdail
Название: Computational Characterisation of Gold Nanocluster Structures
ISBN: 3319014927 ISBN-13(EAN): 9783319014920
Издательство: Springer
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Цена: 19591.00 р.
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Описание: This book presents a detailed analysis of structural preferences in monometallic and bimetallic gold nanoclusters. It characterizes the optical properties of gold-based bimetallic nanoparticles with varying morphologies.

Electronic Characterisation of Earth‐abundant Sulphides for Solar Photovoltaics

Автор: Whittles Thomas James
Название: Electronic Characterisation of Earth‐abundant Sulphides for Solar Photovoltaics
ISBN: 3030062767 ISBN-13(EAN): 9783030062767
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This book examines the electronic structure of earth-abundant and environmentally friendly materials for use as absorber layers within photovoltaic cells. The corroboration between high-quality photoemission measurements and density of states calculations yields valuable insights into why these materials have demonstrated poor device efficiencies in the vast literature cited. The book shows how the materials’ underlying electronic structures affect their properties, and how the band positions make them unsuitable for use with established solar cell technologies. After explaining these poor efficiencies, the book offers alternative window layer materials to improve the use of these absorbers. The power of photoemission and interpretation of the data in terms of factors generally overlooked in the literature, such as the materials’ oxidation and phase impurity, is demonstrated. Representing a unique reference guide, the book will be of considerable interest and value to members of the photoemission community engaged in solar cell research, and to a wider materials science audience as well.

Electronic Characterisation of Earth?Abundant Sulphides for Solar Photovoltaics

Автор: Whittles
Название: Electronic Characterisation of Earth?Abundant Sulphides for Solar Photovoltaics
ISBN: 3319916645 ISBN-13(EAN): 9783319916644
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This book examines the electronic structure of earth-abundant and environmentally friendly materials for use as absorber layers within photovoltaic cells.


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