Thyroid Hormone Disruption and Neurodevelopment, Koibuchi Noriyuki, Yen Paul M.
Автор: Zimmerman Название: Maternal Influences on Fetal Neurodevelopment ISBN: 1603279202 ISBN-13(EAN): 9781603279208 Издательство: Springer Рейтинг: Цена: 24456.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume discusses many issues regarding neurodevelopmental disorders including ADHD, autism, schizophrenia, bipolar disorder and OCD. It explores common themes in prevention, treatment, and research issues surrounding fetal neurodevelopment.
This title includes a number of Open Access chapters.
The rate of identification of children with neurobiological disabilities has been on the increase in recent years. Millions of dollars in research are being spent to understand the factors influencing these increases. The articles within this compendium shed vital light on this issue, confirming that various "ordinary" chemical hazards--of the sort encountered by countless children in their everyday lives--are having serious impacts on development. This volume investigates the impact of exposure to tobacco smoke, household chemicals, lead, agricultural toxins, and flame retardants.
Автор: Keshavan Название: Neurodevelopment and Adult Psychopathology ISBN: 0521485657 ISBN-13(EAN): 9780521485654 Издательство: Cambridge Academ Рейтинг: Цена: 16474.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Factors in the pathogenesis of the major psychiatric disorders are reviewed by an international group of experts in this 1997 book, covering neurodevelopment from the molecular to the behavioural level, clinical applications, and approaches toward a synthesis of neurodevelopmental and clinical findings in psychiatry.
Автор: A. Israel; B. de Strooper; F. Checler; Y. Christen Название: Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate ISBN: 3642627676 ISBN-13(EAN): 9783642627675 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders?
Автор: Noriyuki Koibuchi; Paul M. Yen Название: Thyroid Hormone Disruption and Neurodevelopment ISBN: 1493937359 ISBN-13(EAN): 9781493937356 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. ?
Автор: Andrew W. Zimmerman; Susan L. Connors Название: Maternal Influences on Fetal Neurodevelopment ISBN: 1489981616 ISBN-13(EAN): 9781489981615 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Novel Approaches into the Origins of Neurodevelopmental Disorders: The Fetal Physiology Foundation Over the past two decades, autism, a neurodevelopmental disorder that is defined by behavior and was once believed to be rare, became recognized in increasing numbers of children and recently received distinction as an “epidemic” [1]. While numbers of affected children have steadily increased, our knowledge is still ins- ficient to explain autism’s diverse causes and broad range of presentations. Despite remarkable progress in research, available medical diagnostic testing applies only to a small minority of affected children. Thus, scientifically based explanations with which physicians can diagnose and treat the majority of children with autism and advise their parents are quite limited. Our society and scientific community were unprepared for the rise in autism, which explains our present inability to understand most of its causes. Researchers in neurodevelopmental disorders have long been aware of other disorders that, despite extensive efforts, have not yielded clear genetic or environmental origins, and autism has become symbolic of the need for new approaches to research into these complex conditions. Although autism has captured our attention in recent years, the prevalence of other neurodevelopmental disorders such as attention de- cit hyperactivity disorder (ADHD) and bipolar disorder, among others, also has been increasing [2–4].
Автор: McCusker, Christopher Название: Congenital Heart Disease and Neurodevelopment ISBN: 012801640X ISBN-13(EAN): 9780128016404 Издательство: Elsevier Science Рейтинг: Цена: 11620.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes brings together the work of leading researchers from the U.K., Europe, and the U.S. to provide a comprehensive examination of the causes, risks, and neurodevelopmental and psychological outcomes in children with congenital heart disease. The book includes longitudinal studies which have tracked outcomes from birth through late childhood and explores the emergent phenotype and etiologies, risk, and protective factors that strengthen proposed models.
Medical and surgical advances have meant that greater numbers of children with even the most severe congenital heart disease (CHD) now survive well into adulthood. Studies over the past 20 years have suggested certain neurodevelopmental and psychological features are common, with clinical interventions being internationally articulated. The U.K. Belfast Center has developed and evaluated unique early intervention programs to circumvent the common problems discerned and promote optimal adjustment and outcomes. The first edition of Neurodevelopmental and Psychological Phenotypes in Children with Congenital Heart Disease describes these programs in detail and outlines promising results obtained by researchers worldwide. Such interventions, together with the U.S. consensus statement (Circulation, 2012) on neurodevelopmental screening, hold great promise for clinical interventions.
Features input from leading research experts in the field
Describes cutting-edge research on longitudinal studies that link neurodevelopmental phenotypes with cutting edge neuroimaging studies
Discusses the first series of early intervention studies developed in Belfast targeted at key developmental transitions-birth and diagnosis, early childhood, and adolescence
Includes clinical implications and action points in each section
Features generalizable potential of interventions across other pediatric populations
Автор: Marta C. Antonelli Название: Perinatal Programming of Neurodevelopment ISBN: 1493945564 ISBN-13(EAN): 9781493945566 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The development of the brain and nervous system is shaped not just by a genetic program, but also by the effects of multiple environmental stimuli. The third section of the book will look at ways of translating insights we have garnered from animal studies to human and clinical studies.
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