Описание: This book reviews techniques for assessing insulin action, insulin secretion and body composition, with reference to new drugs, in phase 1 & 2 studies. Adds to understanding of drug effects and non-drug treatment strategies in obesity and type 2 diabetes.
Автор: Song Название: The Long and Short Non-coding RNAs in Cancer Biology ISBN: 9811014965 ISBN-13(EAN): 9789811014963 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.
Автор: Ren, Jun Название: Autophagy and Cardiometabolic Diseases ISBN: 0128052538 ISBN-13(EAN): 9780128052532 Издательство: Elsevier Science Рейтинг: Цена: 19370.00 р. Наличие на складе: Поставка под заказ.
Описание:
Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases.
By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners.
Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases
Provides knowledge from internationally recognized contributors in the field
Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases
Contains access to a companion website with additional illustrations
Автор: Kokkinos Название: Cardiorespiratory Fitness in Cardiometabolic Diseases ISBN: 3030048152 ISBN-13(EAN): 9783030048150 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Поставка под заказ.
Автор: Patrick Ralston Название: Cardiometabolic Diseases and Risk Factors ISBN: 1536181110 ISBN-13(EAN): 9781536181111 Издательство: Nova Science Рейтинг: Цена: 11562.00 р. Наличие на складе: Невозможна поставка.
Описание: In this compilation, the pathogenesis and interrelationships of metabolic abnormalities are discussed, particularly their impact on cardiovascular disease, as well as the role of excess adiposity in metabolic derange. The authors discuss the literature on polycystic ovary syndrome and cardio-metabolic risk factors, providing recommendations that would be helpful for healthcare providers and policy makers. Additionally, the aspects of nutritional habits associated to an increase in cardiovascular risk factors in the obese population are addressed.
Автор: Filipe Palavra; Fl?vio Reis; Daniela Marado; Arman Название: Biomarkers of Cardiometabolic Risk, Inflammation and Disease ISBN: 3319160176 ISBN-13(EAN): 9783319160177 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders.
Название: Fatty Acids and Cardiometabolic Health ISBN: 3038978906 ISBN-13(EAN): 9783038978909 Издательство: Неизвестно Рейтинг: Цена: 9409.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The impact of fat intake on hypercholesterolemia and related atherosclerotic cardiovascular diseases has been studied for decades. However, the current evidence base suggests that fatty acids also influences cardiometabolic diseases through other mechanisms including effects on glucose metabolism, body fat distribution, blood pressure, inflammation, and heart rate. Furthermore, studies evaluating single fatty acids have challenged the simplistic view of shared health effects within fatty acid groups categorized by degree of saturation. In addition, investigations of endogenous fatty acid metabolism, including genetic studies of fatty acid metabolizing enzymes, and the identification of novel metabolically derived fatty acids have further increased the complexity of fatty acids' health impacts. This Special Issue aims to include original research and up-to-date reviews on genetic and dietary modulation of fatty acids, and the role and function of dietary and metabolically derived fatty acids in cardiometabolic health.
Автор: Cefalu, William T. , Cannon, Christopher P. Название: Atlas of Cardiometabolic Risk ISBN: 036738924X ISBN-13(EAN): 9780367389246 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Поставка под заказ.
Описание: The first atlas devoted specifically to cardio-metabolic risk, this book will provide a concise visual primer on the pathophysiology, epidemiology, diagnosis, treatment, and clinical and radiologic features of this disorder. Describing recent care strategies and current practices in patient assessment, this source will allow clinicians to accurately identify and treat those patients at increased risk for metabolic syndrome, cardiovascular disease, and diabetes.
Автор: Xiao Junjie Название: Non-Coding Rnas in Cardiovascular Diseases ISBN: 9811516707 ISBN-13(EAN): 9789811516702 Издательство: Springer Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects.
Автор: Xia Li; Juan Xu; Yun Xiao; Shangwei Ning; Yunpeng Название: Non-coding RNAs in Complex Diseases ISBN: 9811307180 ISBN-13(EAN): 9789811307188 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Поставка под заказ.
Описание: This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.
Автор: Xia Li; Juan Xu; Yun Xiao; Shangwei Ning; Yunpeng Название: Non-coding RNAs in Complex Diseases ISBN: 9811344868 ISBN-13(EAN): 9789811344862 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Поставка под заказ.
Описание: This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.
Автор: Xiao Junjie Название: Non-Coding Rnas in Cardiovascular Diseases ISBN: 9811516731 ISBN-13(EAN): 9789811516733 Издательство: Springer Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects.
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