Описание: Differentiating multiple sclerosis (MS) from alternative demyelinating diseases is challenging. This text guides readers through a number of clinical cases to define MS and rule out competing causes, using specific clinical examples. The text is written in a coaching style, buttressed by the strong pedagogic wisdom of the author.
Автор: Han-Ting Zhang; Ying Xu; James M. O`Donnell Название: Phosphodiesterases: CNS Functions and Diseases ISBN: 3319588095 ISBN-13(EAN): 9783319588094 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Автор: B. Dietzschold; J.A. Richt Название: Protective and Pathological Immune Responses in the CNS ISBN: 354042668X ISBN-13(EAN): 9783540426684 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In spite of the protection of the CNS there are situations where immune responses occur due to different disease processes. While antigen-specific cells of the adaptive immune response are not normally functional in the CNS tissue, CNS resident cells respond to infection or insult.
Автор: Chang Yan-Zhong Название: Brain Iron Metabolism and CNS Diseases ISBN: 9811395888 ISBN-13(EAN): 9789811395888 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.
Автор: Han-Ting Zhang; Ying Xu; James M. O`Donnell Название: Phosphodiesterases: CNS Functions and Diseases ISBN: 3319864793 ISBN-13(EAN): 9783319864792 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Нет в наличии.
Описание: They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Описание: Offers a review of what we know about neural networks. This book advances the understanding of: how the brain carries out important tasks via networks; how these networks interact in normal brain function; major mechanisms that control network function; and the interaction of the normal networks to produce more complex behaviors.
Автор: Lo Название: Vascular Mechanisms in CNS Trauma ISBN: 1461486890 ISBN-13(EAN): 9781461486893 Издательство: Springer Рейтинг: Цена: 30039.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Divided into three sections that cover molecular mechanisms, experimental models and methods, and clinical issues, this work on the vascular aspects of brain and spinal cord trauma features contributions from a wide range of research scientists and clinicians.
Автор: Tonn Название: Oncology of CNS tumors ISBN: 364202873X ISBN-13(EAN): 9783642028731 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Нет в наличии.
Описание: Since the first edition of this popular reference, many new diagnostic procedures and treatment modalities have been developed within neuro-oncology. This edition contains those advances and includes new chapters on palliative care and molecular markers.
Автор: Rita Sattler; Christopher J. Donnelly Название: RNA Metabolism in Neurodegenerative Diseases ISBN: 3030078329 ISBN-13(EAN): 9783030078324 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--?mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--? coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--?directional transcription and production of repeat associated non--?ATG (RAN) translation products.This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
Автор: Li-Ru Zhao; John H. Zhang Название: Cellular Therapy for Stroke and CNS Injuries ISBN: 3319114808 ISBN-13(EAN): 9783319114804 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. Various cells, including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others have had protective or regenerative effects in animal models. The proposed book will address recent research on all relevant cell types. In addition, it will provide information on cell isolation and culture skills, transplantation methods, and neurological functional evaluations. This is the first book to focus on cellular therapy for stroke and other CNS injuries.
Автор: Paul Mandel Название: GABA—Biochemistry and CNS Functions ISBN: 1489952012 ISBN-13(EAN): 9781489952011 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: H.D. Perez; B. Mitrovic; A. Baron Van Evercooren Название: Opportunities and Challenges of the Therapies Targeting CNS Regeneration ISBN: 3642421482 ISBN-13(EAN): 9783642421488 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: New Strategies for CNS Repair.- Heterogeneity of Multiple Sclerosis: Implications for Therapy Targeting Regeneration.- The Neuroprotective Effect of Inflammation: Implications for the Therapy of Multiple Sclerosis.- Fibroblast Growth Factors in Oligodendrocyte Physiology and Myelin Repair.- White Matter Progenitor Cells Reside in an Oligodendrogenic Niche.- At the Interface of the Immune System and the Nervous System: How Neuroinflammation Modulates the Fate of Neural Progenitors In Vivo.- Remyelination and Restoration of Axonal Function by Glial Cell Transplantation.- Gene and Stem Cell Therapy for Autoimmune Demyelination.- Novel Gene Therapeutic Strategies for Neurodegenerative Diseases.- Measuring Injury and Repair of Myelin and Neurons in Multiple Sclerosis.
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