Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols, Mavromoustakos Thomas, Tzakos Andreas G., Durdagi Serdar

Автор: Proetzel Gabriele, Wiles Michael V.
Название: Mouse Models for Drug Discovery: Methods and Protocols
ISBN: 1493981099 ISBN-13(EAN): 9781493981090
Издательство: Springer
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Цена: 15372.00 р.
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Описание: With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, Mouse Models for Drug Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview of techniques to utilize the many possibilities of mice in the drug development process.

Автор: Pfeifer Blaine A., Hill Andrew
Название: Vaccine Delivery Technology: Methods and Protocols
ISBN: 1071607944 ISBN-13(EAN): 9781071607947
Издательство: Springer
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Цена: 18167.00 р.
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Описание: This volume discusses the vaccine development process and the role delivery concepts contribute to a global goal of effective health outcomes.

Автор: Sridar V. Chittur
Название: Microarray Methods for Drug Discovery
ISBN: 1607616629 ISBN-13(EAN): 9781607616627
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Authoritative and cutting-edge, this book provides a single volume reference for all types of microarrays. It supplies new information on microarrays for cytogenetics and drug metabolism, and covers a wide range of microarray platforms.

Автор: Blakemore David, Fobian Yvette, Doyle Paul Jr.
Название: Synthetic Methods in Drug Discovery: Complete Set
ISBN: 1782627871 ISBN-13(EAN): 9781782627876
Издательство: Royal Society of Chemistry
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Цена: 63360.00 р.
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Описание: The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. This two-volume set of books provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Moreover, key opportunities in expanding chemical space are presented, including the increasingly important syntheses that introduce three-dimensional molecular shape. Volume 1 focusses on transition metal mediated methods used in industry and volume 2 covers further valuable methods, such as fluorination, C-N bond formation and asymmetric reactions. Edited and authored by leading scientists from both academia and industry, this set of books will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Автор: Dastmalchi Siavoush, Hamzeh-Mivehroud Maryam, Sokouti Babak
Название: Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery
ISBN: 1522501150 ISBN-13(EAN): 9781522501152
Издательство: Mare Nostrum (Eurospan)
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Цена: 40128.00 р.
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Описание: As the pharmaceutical industry continues to advance, new techniques in drug design are emerging. In order to deliver optimal care to patients, the development of innovative pharmacological techniques has become a widely studied topic.The Handbook of Research on Molecular Docking-Based Drug Design and Discovery investigates the evolution of pharmaceutical design and computational approaches in the field of molecular docking. Highlighting theoretical backgrounds and emergent research in the area of computer-assisted drug design, this publication is a pivotal source for professionals, researchers, medical chemists, pharmaceutical experts, and students interested in innovative practices and findings within the fields of computational chemistry and pharmaceutical sciences.

Автор: Sridar V. Chittur
Название: Microarray Methods for Drug Discovery
ISBN: 1493957392 ISBN-13(EAN): 9781493957392
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Authoritative and cutting-edge, this book provides a single volume reference for all types of microarrays. It supplies new information on microarrays for cytogenetics and drug metabolism, and covers a wide range of microarray platforms.

Автор: Feng Wang
Название: Biomarker Methods in Drug Discovery and Development
ISBN: 1617379255 ISBN-13(EAN): 9781617379253
Издательство: Springer
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Цена: 25853.00 р.
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Описание: In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies.

Автор: Alexander Heifetz
Название: Computational Methods for GPCR Drug Discovery
ISBN: 1493974645 ISBN-13(EAN): 9781493974641
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics.

Автор: Ogris Manfred, Oupicky David
Название: Nanotechnology for Nucleic Acid Delivery: Methods and Protocols
ISBN: 1493959328 ISBN-13(EAN): 9781493959327
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This Methods in Molecular Biology (TM) series book covers nanoparticulate delivery of nucleic acids in terms of biosafety, particle synthesis as well as its application in cell culture. Includes materials and reagents, protocols, notes on troubleshooting and more.

Автор: Anthony E. Klon
Название: Fragment-Based Methods in Drug Discovery
ISBN: 1493924850 ISBN-13(EAN): 9781493924851
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume covers the techniques necessary for a successful fragment-based drug design project, beginning from defining the problem in terms of preparing the protein model, identifying potential binding sites, and the consideration of various candidate fragments for simulation.

Автор: Alexander Heifetz
Название: Computational Methods for GPCR Drug Discovery
ISBN: 1493984942 ISBN-13(EAN): 9781493984947
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modelling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique,Computational Methods for GPCR Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers.