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Mouse Models for Drug Discovery: Methods and Protocols, Proetzel Gabriele, Wiles Michael V.


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Автор: Proetzel Gabriele, Wiles Michael V.
Название:  Mouse Models for Drug Discovery: Methods and Protocols
ISBN: 9781493981090
Издательство: Springer
Классификация:
ISBN-10: 1493981099
Обложка/Формат: Paperback
Страницы: 436
Вес: 0.78 кг.
Дата издания: 26.05.2018
Серия: Methods in molecular biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: 38 tables, color; 37 illustrations, color; 26 illustrations, black and white; xi, 436 p. 63 illus., 37 illus. in color.
Размер: 25.40 x 17.78 x 2.31 cm
Читательская аудитория: General (us: trade)
Подзаголовок: Methods and protocols
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, Mouse Models for Drug Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview of techniques to utilize the many possibilities of mice in the drug development process.
Дополнительное описание: Genetically Defined Strains in Drug Development and Toxicity Testing.- Simple, Efficient CRISPR-Cas9 Mediated Gene Editing in Mice: Strategies and Methods.- Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice.- Generation of Immunodefic



Affinity Chromatography / Methods and Protocols

Автор: Zachariou Michael
Название: Affinity Chromatography / Methods and Protocols
ISBN: 1588296598 ISBN-13(EAN): 9781588296597
Издательство: Springer
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Цена: 2000.00 р.
Наличие на складе: Есть (2 шт.)
Описание: Thirty-eight years after its introduction, affinity chromatography remains a key tool in th armory of separation techniques available to separation and interaction scientists.  Expanded and updated from the first edition, this second edition volume aims to provide the beginner with the practical knowledge needed to develop affinity separations suitable for a variety of applications relevant to the post-genomic era.

Computational Methods for GPCR Drug Discovery

Автор: Alexander Heifetz
Название: Computational Methods for GPCR Drug Discovery
ISBN: 1493974645 ISBN-13(EAN): 9781493974641
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics.

Biomarker Methods in Drug Discovery and Development

Автор: Feng Wang
Название: Biomarker Methods in Drug Discovery and Development
ISBN: 1617379255 ISBN-13(EAN): 9781617379253
Издательство: Springer
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Цена: 25853.00 р.
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Описание: In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies.

Mouse Models for Drug Discovery

Автор: Gabriele Proetzel; Michael V. Wiles
Название: Mouse Models for Drug Discovery
ISBN: 149393659X ISBN-13(EAN): 9781493936595
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Herein, these models are appliedto a wide field of disease areas, including diabetes, cardiovascular disease,skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinaldisorders, as well as various behavioral models.

Mouse Models for Drug Discovery

Автор: Gabriele Proetzel; Michael V. Wiles
Название: Mouse Models for Drug Discovery
ISBN: 1493961217 ISBN-13(EAN): 9781493961214
Издательство: Springer
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Цена: 20263.00 р.
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Описание: With its versatility, ease of use and similarity to the human genome, the mouse has become a top model for medical study. This book provides background of mice as models and details a collection of techniques for a wide variety of specific disease topics.

Synthetic Methods in Drug Discovery: Complete Set

Автор: Blakemore David, Fobian Yvette, Doyle Paul Jr.
Название: Synthetic Methods in Drug Discovery: Complete Set
ISBN: 1782627871 ISBN-13(EAN): 9781782627876
Издательство: Royal Society of Chemistry
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Цена: 63360.00 р.
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Описание: The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. This two-volume set of books provides both academic and industrial perspectives on key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Moreover, key opportunities in expanding chemical space are presented, including the increasingly important syntheses that introduce three-dimensional molecular shape. Volume 1 focusses on transition metal mediated methods used in industry and volume 2 covers further valuable methods, such as fluorination, C-N bond formation and asymmetric reactions. Edited and authored by leading scientists from both academia and industry, this set of books will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Label-Free Biosensor Methods in Drug Discovery

Автор: Ye Fang
Название: Label-Free Biosensor Methods in Drug Discovery
ISBN: 1493926160 ISBN-13(EAN): 9781493926169
Издательство: Springer
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Цена: 20962.00 р.
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Fragment-Based Methods in Drug Discovery

Автор: Anthony E. Klon
Название: Fragment-Based Methods in Drug Discovery
ISBN: 1493924850 ISBN-13(EAN): 9781493924851
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume covers the techniques necessary for a successful fragment-based drug design project, beginning from defining the problem in terms of preparing the protein model, identifying potential binding sites, and the consideration of various candidate fragments for simulation.

Microarray Methods for Drug Discovery

Автор: Sridar V. Chittur
Название: Microarray Methods for Drug Discovery
ISBN: 1493957392 ISBN-13(EAN): 9781493957392
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Authoritative and cutting-edge, this book provides a single volume reference for all types of microarrays. It supplies new information on microarrays for cytogenetics and drug metabolism, and covers a wide range of microarray platforms.

Microarray Methods for Drug Discovery

Автор: Sridar V. Chittur
Название: Microarray Methods for Drug Discovery
ISBN: 1607616629 ISBN-13(EAN): 9781607616627
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Authoritative and cutting-edge, this book provides a single volume reference for all types of microarrays. It supplies new information on microarrays for cytogenetics and drug metabolism, and covers a wide range of microarray platforms.

Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols

Автор: Mavromoustakos Thomas, Tzakos Andreas G., Durdagi Serdar
Название: Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols
ISBN: 107160919X ISBN-13(EAN): 9781071609194
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This detailed book aims to provide readers with critical information to accomplish the synthesis of nanosystems for the purpose of supramolecular entities complexing with drugs, targeted drug delivery system characterization, as well as the study of the physical-chemical interactions that govern the stability and properties of these systems.


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