Statistical Methods in Biomarker and Early Clinical Development, Fang Liang, Su Cheng
Автор: Maisel Alan S., Jaffe Allan S. Название: Cardiac Biomarkers. Case Studies and Clinical Correlations ISBN: 3319429809 ISBN-13(EAN): 9783319429809 Издательство: Springer Рейтинг: Цена: 9782.00 р. 13974.00-30% Наличие на складе: Есть (1 шт.) Описание: This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know.
The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.?
Автор: Edelstein, Charles L. Название: Biomarkers of Kidney Disease ISBN: 0128030143 ISBN-13(EAN): 9780128030141 Издательство: Elsevier Science Рейтинг: Цена: 14654.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book.
This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine.
Автор: Rabbee, Nusrat Название: Biomarker Analysis in Clinical Trials with R ISBN: 1138368830 ISBN-13(EAN): 9781138368835 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book offers practical guidance on how to incorporate biomarker data analysis in clinical trial studies. The book discusses the appropriate statistical methods for evaluating pharmacodynamic, predictive and surrogate biomarkers for delivering increased value in the drug development process.
Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders.
Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests.
Автор: Guest Paul C. Название: Multiplex Biomarker Techniques: Methods and Applications ISBN: 1493982850 ISBN-13(EAN): 9781493982851 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed book arrives as there is an increasing need for multiplex biomarker readouts for improved clinical management and to support the development of new drugs by pharmaceutical companies, due to continuous technical developments and new insights into the high complexity of many diseases.
Описание: This book demonstrates the potential of urine as a biomarker resource for early disease detection, covering the related theory, strategies, tools and findings. The book discusses exciting preliminary applications of urine biomarkers for diseases affecting major biological systems.
Описание: 1. The Potential of 'Omics to Link Lipid Metabolism and Genetic and Comorbidity Risk Factors of Alzheimer's Disease in African Americans.- 2. The Role of Biomarkers in Alzheimer's Disease Drug Development.- 3. Mitochondrial Involvement in Mental Disorders; Energy Metabolism, Genetic and Environmental Factors.- 4. Lymphocytes, Platelets, Erythrocytes and Exosomes as Possible Biomarkers for Alzheimer's Disease Clinical Diagnosis.- 5. Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms.- 6. Neuroimaging Studies of Cognitive Function in Schizophrenia.- 7. The Role of Biomarkers in Psychiatry.- 8. Interactome Studies of Psychiatric Disorders.- 9. MicroRNAs in Major Depressive Disorder.- 10. Proteomic Markers for Depression.- 11. Advances in Biomarker Studies in Autism Spectrum Disorders.- 12. Proteomic Investigations of Autism Spectrum Disorder: Past Findings, Current Challenges and Future Prospects.- 13. Role of the Gut Microbiome in Autism Spectrum Disorders.- 14. Metabolomic Biomarkers in Mental Disorders: Bipolar Disorder and Schizophrenia.- 15. Early Detection and Treatment of Patients with Alzheimer's Disease: Future Perspectives.
Автор: Feng Wang Название: Biomarker Methods in Drug Discovery and Development ISBN: 1617379255 ISBN-13(EAN): 9781617379253 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies.
Автор: Liang Fang; Cheng Su Название: Statistical Methods in Biomarker and Early Clinical Development ISBN: 3030315029 ISBN-13(EAN): 9783030315023 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This contributed volume offers a much-needed overview of the statistical methods in early clinical drug and biomarker development. Chapters are written by expert statisticians with extensive experience in the pharmaceutical industry and regulatory agencies. Because of this, the data presented is often accompanied by real world case studies, which will help make examples more tangible for readers. The many applications of statistics in drug development are covered in detail, making this volume a must-have reference.
Biomarker development and early clinical development are the two critical areas on which the book focuses. By having the two sections of the book dedicated to each of these topics, readers will have a more complete understanding of how applying statistical methods to early drug development can help identify the right drug for the right patient at the right dose. Also presented are exciting applications of machine learning and statistical modeling, along with innovative methods and state-of-the-art advances, making this a timely and practical resource.
This volume is ideal for statisticians, researchers, and professionals interested in pharmaceutical research and development. Readers should be familiar with the fundamentals of statistics and clinical trials.
Автор: Azuale F. Название: Bioinformatics and Biomarker Discovery ISBN: 047074460X ISBN-13(EAN): 9780470744604 Издательство: Wiley Рейтинг: Цена: 17464.00 р. Наличие на складе: Поставка под заказ.
Описание: Bioinformatics and Biomarker Discovery: ?€?Omic?€? Data Analysis for Personalized Medicine is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the di
Автор: Virginie Brun; Yohann Cout? Название: Proteomics for Biomarker Discovery ISBN: 1493991639 ISBN-13(EAN): 9781493991631 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume presents modern and enhanced methods that detail techniques to perform proteomics analyses dedicated to biomarker discovery for human health. Chapters guide readers through pre/post analytical factors, protocols for the preparation of extracellular vesicles and exosomes, and various analytical pipelines including Data Independent Acquisition (DIA), discovery, as well as targeted and top-down proteomics analysis workflows. Bioinformatics tools and workflows to select and evaluate candidate biomarkers or combinations of biomarkers are also presented. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Proteomics for Biomarker Discovery: Methods and Protocols aims to ensure successful results in the further study of this vital field.
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