New Frontiers: Extracellular Vesicles, Mathivanan Suresh, Fonseka Pamali, Nedeva Christina
Автор: Eric G. Schmuck; Peiman Hematti; Amish N. Raval Название: Cardiac Extracellular Matrix ISBN: 303007353X ISBN-13(EAN): 9783030073534 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.
Автор: DeSimone Douglas W Название: Extracellular Matrix in Development ISBN: 3642359345 ISBN-13(EAN): 9783642359347 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function.
Описание: Extracellular vesicles are small vesicles (or membrane-bound organelles) that can be found in blood and other biofluids and their internal content and surface reflect their origin and potential function. Extracellular Vesicles: Mechanisms and Role in Health and Disease begins with a summary of the most recent findings about the potential role of extracellular vesicles in human health and diseases and discusses future directions. The authors discuss how intercellular communication at the developing feto-maternal interface is of cardinal interest. The implantation itself is at least partially-dependent on extracellular vesicles mediated processes. Furthermore, the altered local and systemic immunomodulatory state seems to be significantly influenced by proteomic and nucleic acid cargo found in extracellular vesicles. Lastly, recent studies in the development of metastatic potential are studied by focusing on the role of oxidative stress under the control of reprogrammed onco-metabolism using the LNCaP-C4-2B prostate cancer progression model system.
Автор: Galluzzi, Lorenzo Название: Extracellular Vesicles,645 ISBN: 0128206624 ISBN-13(EAN): 9780128206621 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Extracellular Vesicles, Volume 645 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Genetic labeling of extracellular vesicle exosomes for studying biogenesis and uptake in living mammalian cells, Fluorescent Labeling of Extracellular Vesicles, Isolation of extracellular vesicles from lymph, Transgenic rats for tracking body fluid/tissue-derived extracellular vesicles, Isolation of amniotic extracellular vesicles, Urinary extracellular vesicle isolation, Immunocapture-based ELISA to Characterize and Quantify Extracellular Vesicles in Both Cell Culture Supernatants and Body Fluids, and much more.
Автор: Winston Patrick Kuo; Shidong Jia Название: Extracellular Vesicles ISBN: 1493972510 ISBN-13(EAN): 9781493972517 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume examines established methods and protocols to isolate and characterize extracellular vesicles (EVs) and their composition, among other techniques including purification, imaging, biofluid-specific and cell-specific isolation and downstream genomic and proteomic profiling.
Автор: Winston Patrick Kuo; Shidong Jia Название: Extracellular Vesicles ISBN: 1493984314 ISBN-13(EAN): 9781493984312 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Поставка под заказ.
Описание: This volume examines established methods and protocols to isolate and characterize extracellular vesicles (EVs) and their composition, among other techniques including purification, imaging, biofluid-specific and cell-specific isolation and downstream genomic and proteomic profiling.
Автор: Anna C. Berardi Название: Extracellular Matrix for Tissue Engineering and Biomaterials ISBN: 3319770217 ISBN-13(EAN): 9783319770215 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a state-of-art-report on the new methodologies in tissue engineering and developments in the biomaterials field based on the extracellular matrix-relevant discovery. Extracellular Matrix for Tissue Engineering and Biomaterials opens with an overview of the latest extracellular matrix research and in Part I, focuses on its biology and its role on cell behavior and cell fate relevant for the design of biomimetic surfaces. Part II details issues regarding the strategies currently applied in the research of biologically inspired materials and material systems for the replacement, repair and regeneration of tissues and organs. Part III presents the latest development methods applying knowledge from biology towards nanotechnology, to promote the restoration of the functionality of a living tissue. The book ranges from fundamental biology associated with tissue regeneration for the development of biomimetic approaches to controlling tissue formation, cell function, differentiation and angiogenesis using factors involved in normal tissue development and function. With the breadth and depth of the coverage of this topic, this book will serve as a valuable reference for anyone working in tissue engineering or biomaterials – from scientists, chemists and biologists through physicists, bioengineers and clinicians.
Автор: Roy Zent; Ambra Pozzi Название: Cell-Extracellular Matrix Interactions in Cancer ISBN: 1489981128 ISBN-13(EAN): 9781489981127 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes how extracellular matrix components (ECM) create a niche for tumor formation. It also discusses the contribution of ECM components and their respective receptors in the development and spread of cancer.
Автор: Davide Vigetti; Achilleas D. Theocharis Название: The Extracellular Matrix ISBN: 1493991329 ISBN-13(EAN): 9781493991327 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details established experimental protocols on the isolation, characterization, and detection of extracellular matrix (ECM) molecules as well as methods to study the activity and role of ECM components on various biological functions, the formation of exosomes, and tissue surrogates. Chapters display a variety of protocols ranging from biochemical, cell, and molecular biology assays to complex tissue imaging techniques and in vivo models to elucidate the role of the extracellular matrix. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, The Extracellular Matrix: Methods and Protocols aims to provide protocols and applications that can be used by both Ph.D. students and senior researchers to advance research in the field of extracellular matrix biology.
Автор: Ricard-Blum Sylvie Название: Extracellular Matrix Omics ISBN: 3030583295 ISBN-13(EAN): 9783030583293 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers different omics aspects related to the extracellular matrix (ECM), namely specific omics resources focused on the extracellular matrix (e.g., databases, repositories and atlases), quantitative proteomics applied to specific extracellular matrices (e.g.
Автор: Struther Arnott; D. A. Rees; E. R. Morris Название: Molecular Biophysics of the Extracellular Matrix ISBN: 0896030512 ISBN-13(EAN): 9780896030510 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This work offers an interdisciplinary synthesis of what is currently known about the molecular architecture and properties of the complex biological milieux in which cells exist and function.
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