Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy, Ganai Shabir Ahmad

Автор: Tso-Pang Yao; Edward Seto
Название: Histone Deacetylases: the Biology and Clinical Implication
ISBN: 3642270859 ISBN-13(EAN): 9783642270857
Издательство: Springer
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Цена: 41925.00 р.
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Описание: The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Автор: Nicola J. Curtin; Ricky A. Sharma
Название: PARP Inhibitors for Cancer Therapy
ISBN: 3319141503 ISBN-13(EAN): 9783319141503
Издательство: Springer
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Цена: 23757.00 р.
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer.

Автор: Sa?d M. Sebti; Andrew D. Hamilton
Название: Farnesyltransferase Inhibitors in Cancer Therapy
ISBN: 1468496069 ISBN-13(EAN): 9781468496062
Издательство: Springer
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Цена: 20962.00 р.
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Автор: Fang Dong, Han Junhong
Название: Histone Mutations and Cancer
ISBN: 9811581037 ISBN-13(EAN): 9789811581038
Издательство: Springer
Цена: 13974.00 р.
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Описание: This book focuses on histone mutations, especially those mutations closely related to cancer.

Автор: Eric Verdin
Название: Histone Deacetylases
ISBN: 1617376027 ISBN-13(EAN): 9781617376023
Издательство: Springer
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Цена: 34799.00 р.
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Описание: A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression.

Автор: Ashkan Emadi, Judith E. Karp, Candace B. Mainor
Название: Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs
ISBN: 0826162037 ISBN-13(EAN): 9780826162038
Издательство: Mare Nostrum (Eurospan)
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Цена: 13860.00 р.
Наличие на складе: Нет в наличии.

Описание: Provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology.

Автор: Curtin Nicola J., Sharma Ricky A.
Название: Parp Inhibitors for Cancer Therapy
ISBN: 3319344897 ISBN-13(EAN): 9783319344898
Издательство: Springer
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Цена: 20962.00 р.
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

Автор: Antonio Giordano; Kenneth J. Soprano
Название: Cell Cycle Inhibitors in Cancer Therapy
ISBN: 1617372579 ISBN-13(EAN): 9781617372575
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases.

Автор: Julian Adams
Название: Proteasome Inhibitors in Cancer Therapy
ISBN: 1617374520 ISBN-13(EAN): 9781617374524
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Takes stock of the work that has been accomplished with proteasome inhibitors in cancer, and examines various therapeutic possibilities. This title covers topics ranging from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of clinical trials underway.

Автор: Vitaly A. Polunovsky; Peter J. Houghton
Название: mTOR Pathway and mTOR Inhibitors in Cancer Therapy
ISBN: 1617796948 ISBN-13(EAN): 9781617796944
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island).

Автор: Atsushi Kaneda; Yu-ichi Tsukada
Название: DNA and Histone Methylation as Cancer Targets
ISBN: 3319597841 ISBN-13(EAN): 9783319597843
Издательство: Springer
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Цена: 27950.00 р.
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Описание:

This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Автор: Stefan Jurga; Jan Barciszewski
Название: The DNA, RNA, and Histone Methylomes
ISBN: 3030147916 ISBN-13(EAN): 9783030147914
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.