Applications of Mass Spectrometry in Microbiology: From Strain Characterization to Rapid Screening for Antibiotic Resistance, Demirev Plamen, Sandrin Todd R.
Описание: This book identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities.
Автор: Anthony R.M. Coates Название: Antibiotic Resistance ISBN: 3642432492 ISBN-13(EAN): 9783642432491 Издательство: Springer Рейтинг: Цена: 55901.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.
Описание: This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
Автор: Kon, Kateryna Название: Antibiotic Resistance ISBN: 0128036427 ISBN-13(EAN): 9780128036426 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "
Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches" discusses up-to-date knowledge in mechanisms of antibiotic resistance and all recent advances in fighting microbial resistance such as the applications of nanotechnology, plant products, bacteriophages, marine products, algae, insect-derived products, and other alternative methods that can be applied to fight bacterial infections.
Understanding fundamental mechanisms of antibiotic resistance is a key step in the discovery of effective methods to cope with resistance. This book also discusses methods used to fight antibiotic-resistant infection based on a deep understanding of the mechanisms involved in the development of the resistance. Discusses methods used to fight antibiotic-resistant infection based on a deep understanding of mechanisms involved in the development of the resistanceProvides information on modern methods used to fight antibiotic resistanceCovers a wide range of alternative methods to fight bacterial resistance, offering the most complete information availableDiscusses both newly emerging trends and traditionally applied methods to fight antibiotic resistant infections in light of recent scientific developmentsOffers the most up-to-date information in fighting antibiotic resistanceIncludes involvement of contributors all across the world, presenting questions of interest to readers of both developed and developing countries
Описание: Only by understanding the historical forces that have shaped our current situation, Podolsky argues, can we properly understand and frame our choices moving forward.
Автор: Schiesser, William E. Название: Ode/Pde Analysis Of Antibiotic/Antimicrobial Resistance ISBN: 0128240024 ISBN-13(EAN): 9780128240021 Издательство: Elsevier Science Рейтинг: Цена: 22401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Manaia Cйlia M., Donner Erica, Vaz-Moreira Ivone Название: Antibiotic Resistance in the Environment: A Worldwide Overview ISBN: 3030550648 ISBN-13(EAN): 9783030550646 Издательство: Springer Рейтинг: Цена: 53106.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a multidisciplinary review of antibiotic resistance and unravels the complex and interrelated roles of environmental sources, including pharmaceutical industry effluents, hospital and domestic effluents, wildlife and drinking water. Antibiotic resistance is a global public health issue in which the interface between humans, animals and the environment is particularly relevant. The contrasts seen across different environmental compartments and world regions, which are due to climate, social and policy differences, mean that this problem needs to be analyzed from a multi-geographic and multi-cultural angle. Bringing together contributions from researchers on different continents with expertise in antibiotic resistance in a range of different environmental compartments, the book offers a detailed reflection on the paths that make antibiotic resistance a global threat, and the state-of- the-art in antibiotic resistance surveillance and risk assessment in complex environmental matrices.
Автор: Demirev, Plamen, Sandrin, Todd R. (Eds. Название: Applications of Mass Spectrometry in Microbiology ISBN: 3319260685 ISBN-13(EAN): 9783319260686 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As of mid-2015, more than 3300 commercial MS systems for microorganism identification have been deployed worldwide in hospitals and clinical labs. While previous work has covered broader approaches in using MS to characterize microorganisms at the species level or above, this book focuses on strain-level and subtyping applications.
Описание: During recent years there has been increasing interest in the value of a number of chemical and physical-chemical analytical methods for the detection and characterization of microorganisms. Furthermore, such methods are currently used in studies on microbial metabolic processes, on the role of microorganisms in the turnover of inorganic and organic compounds, and on the impact on environmental changes by microbial activity. Moreover, the introduction of some of these methods not only shortens the analytical time period compared to ·'traditional" techniques, but also improves the analytical quality. Mass spectrometry (MS) combined with chromatographic inlet systems, particularly gas chromatography (GC), belongs to those methods which during recent years have established their value for the above-mentioned purposes. The present volume starts with basic chapters on the principles for MS and common inlet systems, particulary Gc. It discusses applications of these techniques to a number of microbiological disciplines, e.g., ecologi cal and medical microbiology. Emphasis is laid on organic compound classes vii viii / PREFACE of special relevance to microbiology, e.g., volatiles, lipids, amino acids, peptides and carbohydrates. Some compound classes of a more general biochemical rather than specific microbiological importance, e.g., steroids and nucleotides, are dealt with briefly. The editors wish to thank all those who have contributed to this book. We hope it will stimulate further research in this futuristic field and will be of practical value.
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