Gene Expression and Its Discontents: The Social Production of Chronic Disease, Wallace Rodrick, Wallace Deborah
Автор: Rodrick Wallace; Deborah Wallace Название: Gene Expression and Its Discontents ISBN: 3319480774 ISBN-13(EAN): 9783319480770 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.
This title includes a number of Open Access chapters.
This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice.
The book includes chapters on these topics:
- Gene expression in colon cancer tissue
- Epigenetics in human acute kidney injury
- Embryologically relevant candidate genes in MRKH patients
- DNA methylation in common skeletal disorders
- Causal relationships in genomics
- Predicting severe asthma exacerbations in children
- Epigenetic understanding of gene-environment interactions in psychiatric disorders
Автор: Rodrick Wallace; Deborah Wallace Название: Gene Expression and Its Discontents ISBN: 148998531X ISBN-13(EAN): 9781489985316 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner.
Автор: Barash David P. Название: Threats: Intimidation and Its Discontents ISBN: 0190055294 ISBN-13(EAN): 9780190055295 Издательство: Oxford Academ Рейтинг: Цена: 4196.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Threats is a comprehensive and scientifically accurate exploration into threats at every level, from animalistic competition to social manipulation and political strife.
Автор: Wallace Название: Collective Consciousness and Its Discontents: ISBN: 1441945741 ISBN-13(EAN): 9781441945747 Издательство: Springer Рейтинг: Цена: 14673.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An earlier book by Rodrick Wallace entitled Consciousness: A Mathematical Treatment of the Global Neuronal Workspace Model, introduced a formal information-theoretic approach to individual consciousness. This latest book takes a more formal `groupoid` perspective to its predecessor and generalizes the results presented in that earlier book.
Автор: F. Kenney Название: Gene Expression and its Regulation ISBN: 1468408798 ISBN-13(EAN): 9781468408799 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Eleventh International Latin American Symposium is an important mile- stone reflecting the rapid development of basic biochemistry in Latin America.
This title includes a number of Open Access chapters.
This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including:
host-pathogen interactions
causal relationships between genes and the environment
the effects of environmental chemicals on gene expression
DNA methylation
The book also covers the analysis and provides models for understanding the epigenetics-pathology connection.
This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.
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