Автор: Seymour Garte Название: Genetic Susceptibility to Cancer ISBN: 1461372658 ISBN-13(EAN): 9781461372653 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent research has discovered that for many of these `sporadic` (non-familial) cancer cases, defects or aberrations in certain metabolic genes not previously associated with genetic cancer risk may contribute to either causing the disease or at least increasing the chances of developing cancer.
Автор: Seymour Garte Название: Genetic Susceptibility to Cancer ISBN: 0792383834 ISBN-13(EAN): 9780792383833 Издательство: Springer Рейтинг: Цена: 27951.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent research has discovered that for many of these `sporadic` (non-familial) cancer cases, defects or aberrations in certain metabolic genes not previously associated with genetic cancer risk may contribute to either causing the disease or at least increasing the chances of developing cancer.
Автор: David E. Briles Название: Genetic Control of the Susceptibility to Bacterial Infection ISBN: 3540162380 ISBN-13(EAN): 9783540162384 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This series ofreviews focuses on recent developments in understandingbacterialpathogenesisthathavebeengained by studying the genetic control of the susceptibility to particular diseases. The topics of the reviews include a description ofbacterial genes that effect virulence and a studyofthe genetic susceptibilityofhumans to group A streptococci and to leprosy. The most versatile model system for studies of disease susceptibility is the inbred mouse. Although seven of the chapters deal with the geneticsoftheresistanceofmice to infection, allofthem point out general principles and, wherever possible, parallelswithappropriatehumandiseases. Genetic studies of the mechanisms of resistance and pathogenesishaveanadvantageoverotherapproaches. By utilizing animals ofappropriate genotypes, it is possible tostudytheinvivoconsequencesofvariationsinparticular hostdefensesinintactanimals.Someofthemoderngenetic approachesusedinmousegeneticsarealsodescribed. Allofthechaptersdealingwithmousegeneticsdescribe studieswithrecombinantinbredmice.Achapterhasbeen included thatdescribesapproaches for the useofmice in genetic studies of disease resistance. This chapter also describesrecombinantinbred miceandameans bywhich theycanbeusedtoexaminethelinkageofgenesaffecting diseaseresistance. Thebulkofthevolumefocusesonthegeneticregulation by three different murine loci: Ips, xid, and fty. fty was the first name given to a locusthatgoverns resistance to infections with leishmania, bacille Calmette-Guerin and salmonella. Different reviews describe the relationshipof thefty locusto thediseasescaused bytwoofthese three pathogens. Thesetwo reviewsalsoincludeadiscussionof other geneticfactors that affect the susceptibilityofmice toeachpathogen.TworeviewsaredevotedtotheX-linked immunodeficiency (xid) locus. One describes the pre- sent state of immunological knowledge about the immunological deficits that have been shown to be VI Preface associatedwiththedefectivexidallele.Theotherdescribes theeffectoftheseimmunodeficienciesonthesusceptibility of mice to infection with Streptococcus pneumoniae. Anotherchapter describes the effectsofthe Ips locus on the immune system and the concomitant effects these changeshaveontheresistancetobacterialinfection.There is also a chapter describing genetic studies that examine the relationship between the genetic control of certain macrophage properties and the susceptibility to Listeria infection.
Автор: Webb Michelle Название: Cancer Susceptibility: Methods and Protocols ISBN: 1493957600 ISBN-13(EAN): 9781493957606 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the past two decades, spectacular advances have been made in our understanding of the molecular genetics of cancer, leading to the pursuit of identifying genes that, when mutated, result in an increased susceptibility to the disease. In Cancer Susceptibility: Methods and Protocols, experts in the field bring together the most recent technological developments for identifying and screening cancer susceptibility genes. Divided into two clear sections, the book begins with gene identification, which updates and informs scientists working at identifying novel cancer susceptibility genes, while the second part deals with mutation screening technologies that aid scientists and clinicians working to translate this knowledge into the clinic. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Susceptibility: Methods and Protocols is a timely collection that seeks to provide researchers with the tools to predict and combat this terrible disease.
Описание: Proceedings of a NATO ARW held in Pittsburgh, Pennsylvania, June 23-27, 1992.
Автор: James A. Poupard; Lori R. Walsh; Bruce Kleger Название: Antimicrobial Susceptibility Testing ISBN: 1475792085 ISBN-13(EAN): 9781475792089 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: J ames Poupard Lori Walsh Bruee Kleger ix CONTENTS 1 Introduction 1: CURRENT METHODS The Evolution of Antimicrobial Susceptibility Testing Methods . Bartlett Areas of Recent Emphasis of the National Committee for Clinical Laboratory Standards Subcommittee on Antimicrobial Susceptibility Testing .
Описание: 1. Concept on Landslides and Landslide Susceptibility2. Geomorphic, Geo-tectonic and Hydrologic Attributes and Landslide Probability3. Frequency Ratio Model (FRM) and Information Value Model (IVM) in landslide susceptibility Assessment and Prediction4. Logistic Regression Model (LRM) and Landslide Susceptibility: A RS & GIS based approach5. Artificial Neural Network (ANN) Model and Landslide Susceptibility6. Weighted Index Overlay Model (WIOM), Certainty factor approach (CFA) and Analytical Hierarchy Process (AHP) in Landslide Susceptibility Studies7. Knowledge driven Statistical Approach for Landslide Susceptibility Assessment using GIS and Fuzzy Logic8. Comparison between Statistical Models: A Review and EvaluationIndex
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