This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges.
Автор: Ghosh Dipanjan Название: Advances in Crispr/Cas and Related Technologies, 178 ISBN: 0128215909 ISBN-13(EAN): 9780128215906 Издательство: Elsevier Science Рейтинг: Цена: 20043.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Advances in CRISPR/Cas and related technologies, Volume 179, the latest release in this ongoing series, deals with a wide variety of research topics related to recent advancement in the genome editing techniques. Associated chapters in this new release include Challenges for Therapeutic application of CRISPR Cas techniques, Mitochondrial DNA modification by CRISPR Cas System: Challenges and future direction, Trends in CRISPR Cas technology application in cancer, Modified CRISPR-Cas for next generation application, Application of CRISPR Cas in Synthetic Biology: Challenges and Scopes, History of CRISPR Cas system from bacterial Adaptive Immune System to research application, and more
Описание: This book features 21 papers spanning many different sub-fields in bioinformatics and computational biology, presenting the latest research on the practical applications to promote fruitful interactions between young researchers in different areas related to the field. Next-generation sequencing technologies, together with other emerging and diverse experimental techniques, are evolving rapidly, creating numerous types of omics data. These, in turn, are creating new challenges for the expanding fields of bioinformatics and computational biology, which seek to analyse, process, integrate and extract meaningful knowledge from such data. This calls for new algorithms and approaches from fields such as databases, statistics, data mining, machine learning, optimization, computer science, machine learning and artificial intelligence. Clearly, biology is increasingly becoming a science of information, requiring tools from the computational sciences. To address these challenges, we have seen the emergence of a new generation of interdisciplinary scientists with a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific areas is, more than ever, vital to boost the research efforts in the field and contribute to the training of the new generation of interdisciplinary scientists.
Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more.
Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics.
Автор: Burns Malcolm, Foster Lucy, Walker Michael Название: DNA Techniques to Verify Food Authenticity: Applications in Food Fraud ISBN: 1788011783 ISBN-13(EAN): 9781788011785 Издательство: Royal Society of Chemistry Рейтинг: Цена: 31469.00 р. Наличие на складе: Поставка под заказ.
Описание: Providing the most comprehensive and timely collection of material from those working at the forefront of DNA techniques applied to food authenticity, this book will appeal to food testing laboratories worldwide and food policy professionals and regulatory organisations who will be using these techniques to back up legislation and regulation.
Описание: This book covers major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. It is helpful for immunologists, biochemists, molecular biologists, cellular biologists, and clinical chemists.
Описание: Influential researchers comprehensively survey the basic and clinical aspects of the insulin-like growth factor system. Their state-of-the-art synthesis of a broad range of IGF research illuminates the interplay among ligands, receptors, and binding proteins, each exerting both the local and systemic effects that constitute this complex system. The book examines in detail not only the molecular biology, the biological actions, and the physiology of the various IGF systems, but also the clinical aspects of the IGF system, ultimately producing a useful paradigm for the investigation of related hormone, growth factor, and cytokine signaling systems. The IGF System: Molecular Biology, Physiology, and Clinical Applications is the first extended treatment of the IGF system in many years and is designed to serve as the new standard reference-of-choice for all basic and clinical investigators, as well as practicing physicians treating a range of human diseases, including cancer, diabetes, and neurodegenerative disorders.
Описание: Evolutionary biology is applied to a wide range of practical problems in law, medicine, agriculture, the environment, and society. Although these applications can have a dark side, rapid progress is underway or should be expected in the near future due to recent advances in DNA sequencing, new gene editing tools, and computational methods.
Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems Part B, represents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. It is a simple, rapid, precise, and cost-effective tool for genome editing and regulation of a wide range of organisms. It has gained scientific and public attention worldwide. This volume mainly covers insect cell line, protozoans, zebrafish, drosophila, CRISPRi, patents as well as technology transfer, and many more. This book is a key source of information available in a single volume. This book will be useful for not only beginners in genome engineering, but also students, researchers, scientists, policymakers, and stakeholders interested in harnessing the potential of reprogramming of the genomes in several areas.
Автор: Bhattacharya Anjanabha, Parkhi Vilas, Char Bharat Название: CRISPR/Cas Genome Editing: Strategies And Potential For Crop Improvement ISBN: 3030420248 ISBN-13(EAN): 9783030420246 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction to genome editing techniques: Implication in modern agriculture.- Application of bioinformatics tools in CRISPR/Cas.- CRISPR and food security: Application in cereal crops.- Improvement of floriculture crops using CRISPR/Cas and genome editing techniques.- Engineering crop plant resistance against abiotic stresses: CRISPR/Cas application and challenges.- Vegetable crop improvement using CRISPR/Cas.- Use of CRISPR/Cas in climate smart/resilient agriculture.- Intellectual Property Landscape on CRISPR/Cas.
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