This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Patil Popat M Название: Discoveries In Pharmacological Sciences ISBN: 9814355070 ISBN-13(EAN): 9789814355070 Издательство: World Scientific Publishing Рейтинг: Цена: 27720.00 р. 39600.00-30% Наличие на складе: Есть (1 шт.) Описание: Throughout history, the perpetuation of species, the need for survival, and human curiosity, intelligence and skills provided the basis for the development of drug science. This title contains the history of herbal medicine as it emerged about 5,000 years ago.
Описание: This volume arose from the scientific program of the XIIth International Congress of Pharmacology, held in Montreal, Canada, July 24-29, 1994. The objective that we pursued was to produce a volume of reasonable size which would feature all of the plenary lectures and symposia from those authors who agreed to participate.
Описание: Patients with peripheral vascular disease (PVD) are at increased risk of death when compared with age-matched healthy controls. They are also, whether symptomatic or not, six times more likely to die within ten years when compared to patients without the disease. This excess mortality exists even if coronary artery disease is not clinically present, and makes the treatment of PVD a highly important and pressing topic. In this fully up-to-date text, Dr. Mukherjee and his excellent team of twenty-one contributors present the reader with all of the currently available clinical information for treating PVD patients effectively.
Описание: Integrating Psychological and Pharmacological Treatments for Addictive Disorders distills the complex literature on addiction, offering a curated toolbox of integrated pharmacological and psychotherapeutic treatments in chapters authored by leading experts.
Описание: Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar- macological treatment is currently available.
Описание: This set of six volumes provides a systematic and standardized description for 23,033 chemical components isolated from 6,734 medicinal plants. It provides a chemical structure with stereo-chemistry bonds for each chemical component.
Автор: Natalie Lajoie Название: The Pharmacological Guide to Metformin ISBN: 1536166340 ISBN-13(EAN): 9781536166347 Издательство: Nova Science Рейтинг: Цена: 22491.00 р. Наличие на складе: Невозможна поставка.
Описание: Almost six decades after its discovery, metformin still remains the gold standard drug for the management of type 2 diabetes mellitus, owing to its euglycemic property and cost-effectiveness. It is the most commonly prescribed and utilized oral antidiabetic drug worldwide. However, no two persons with the same phenotypical characteristics, such as age, gender, body weight and others, tend to respond similarly to equivalent doses of metformin. As such, The Pharmacological Guide to Metformin first focuses on the various genetic polymorphisms that influence the therapeutic effects of metformin. Physicochemical, pharmacological, and pharmacokinetic properties of metformin will also be reviewed. The side effects of this drug can be dangerous. Metformin-induced lactic acidosis is a lethal disorder. The first significant deviation is gastrointestinal tract involvement. Common infection or the effect of metformin itself causes vomiting and diarrhea, with subsequent hypovolemia causing pre-renal acute kidney injury, which in turn raises metformin levels up to toxic values. Development of kidney failure is often unexpected and fast. Following this, the authors explore the differences between healthy and cancer cells and how this may influence the metformin effect on these cells. In conclusion, the molecular mechanisms underlying the anticancer effects of metformin in breast and ovarian cancers are summarized, and the potential anticancer applications of metformin-based combinatorial chemotherapy are discussed.
Автор: T. Godfraind; G. Mancia; M.P. Abbracchio; L. Aguil Название: Pharmacological Control of Calcium and Potassium Homeostasis ISBN: 9401040567 ISBN-13(EAN): 9789401040563 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. Calcium homeostasis within the cell is not only regulated by calcium channels;
Автор: Feldman Название: Heart Failure; Pharmacologic Management. 2006 ISBN: 1405103612 ISBN-13(EAN): 9781405103619 Издательство: Wiley Рейтинг: Цена: 17099.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Now there is an up-to-date guide for optimizing pharmacologic therapy in treating patients with heart failure. Reflecting current practice at leading medical centers, Heart Failure: Pharmacologic Management provides both the biologic and pathologic underpinnings of each pharmacologic agent in current use.
Автор: Ronald J. Tallarida; Rodney B. Murray Название: Manual of Pharmacologic Calculations ISBN: 1461293804 ISBN-13(EAN): 9781461293804 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book contains a collection of quantitative procedures in common use in pharmacology and related disciplines. In this new edition we have increased the number of procedures from 33 (in the first edition) to 48. An associated computer program is included for each procedure and its use is illustrated with the same worked example used in the text.
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