Описание: With the discovery of an ever increasing number of biogenetic polypeptides in the autonomic nervous system, it is evident that nervous transmission is controlled and modified not only by a series of classical transmitters but also by a variety of co-transmitters and modulators. Purifi- cation, characterization and synthesis of neuropeptides and peptide families allows the application of specific anti- bodies for radioimmunological, immunohistochemical and immunocytochemical localization. Transmitter interactions and phenotypic neuronal plasticity can be analyzed by pharmacological or surgical manipulations. Biochemical and autoradiographic determination of specific membrane receptors enables the recognition of peptide target struc- tures. In addition, neurophysiological techniques in combi- nation with histochemical methods result in functional interpretations. With regard to somatic manifestations of autonomic nervous disturbances these studies will offer fundamental insights for clinical medicine. This volume contains the refereed proceedings of recent investigations on histochemistry and cell biology of auton- omic neurons and paraganglia which were presented at an international colloquium on nervous transmission in Heidelberg in September 1986. The colloquium was origi- nally planned to be held under the presidency of Olavi Eranko but was continued by the editor after his death. It was sponsored by the German Research Foundation and took place on the occasion of the 600th anniversary of the Heidelberg University "Ruperto Carola" as part of the pro- gram in the international "Wissenschaftsforum". Hopefully, the information provided in this book will stimu- late new ideas and research strategies in the field of neu roscience.
Описание: Introduction.- Part I: Preliminaries.- Foundations of artificial neural networks.- Part II: Mathematical foundations.- General foundations.- Foundations of dynamical systems theory.- Part III: Mathematical models of the neuron.- Models of the whole neuron.- Models of parts of the neuron.- Part IV: Mathematical models of the perceptron.- General model of the perceptron.- Linear perceptrons.- Weakly nonlinear perceptrons.- Nonlinear perceptrons.- Concluding remarks and comments.
Автор: Jos? Mar?a Frade; Fred H. Gage Название: Genomic Mosaicism in Neurons and Other Cell Types ISBN: 1493972790 ISBN-13(EAN): 9781493972791 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Neuromethods Series Preface... Preface... Table of Contents... Contributing Authors...
Part I Introduction
1. Principles and Approaches for Discovery and Validation of Somatic Mosaicism in the Human Brain Alexej Abyzov, Alexander E. Urban, and Flora M. Vaccarino
Part II Aneuploidy and Ploidy Variation
2. FISH-Based Assays for Detecting Genomic (Chromosomal) Mosaicism in Human Brain Cells Yuri B. Yurov, Svetlana G. Vorsanova, Ilia V. Soloviev, Alexei M. Ratnikov, and Ivan Y. Iourov
3. Flow Cytometric and Sorting Analyses for Nuclear DNA Content, Nucleotide Sequencing and Interphase FISH Gwendolyn E. Kaeser and Jerold Chun
4. Flow Cytometric Quantification, Isolation, and Subsequent Epigenetic Analysis of Tetraploid Neurons Noelia Lуpez-Sбnchez, Iris Patiсo-Parrado, and Josй M. Frade
5. A Cytomic Approach towards Genomic Individuality of Neurons Thomas Arendt, Birgit Belter, Martina K. Brьckner, Uwe Ueberham, Markus Morawski, and Attila Tarnok
Part III DNA Copy Number Variation
6. Single Cell CNV Detection in Human Neuronal Nuclei Margaret B. Wierman, Ian E. Burbulis, William D. Chronister, Stefan Bekiranov, and Michael J. McConnell
7. Multiple Annealing and Looping-Based Amplification Cycles (MALBAC) for the Analysis of DNA Copy Number Variation Chenghang Zong
8. Competitive PCR for Copy Number Assessment by Restricting dNTPs Luming Zhou, Robert A. Palais, Yotam Ardon, and Carl T. Wittwer
9. Using Cloning to Amplify Neuronal Genomes for Whole Genome Sequencing and Comprehensive Mutation Detection and Validation Jennifer L. Hazen, Michael A. Duran, Ryan P. Smith, Alberto R, Rodriguez, Greg S. Martin, Sergey Kupriyanov, Ira M. Hall, and Kristin K. Baldwin
Part IV LINE-1 Retrotransposition
10. Analysis of LINE-1 Retrotransposition in Neural Progenitor Cells and Neurons Angela Macia and Alysson R. Muotri
11. Estimation of LINE-1 Copy Number in the Brain Tissue and Isolated Neuronal Nuclei Miki Bundo, Tadafumi Kato, and Kazuya Iwamoto
12. Analysis of Somatic LINE-1 Insertions in Neurons Francisco J. Sanchez-Luque, Sandra R. Richardson, and Geoffrey J. Faulkner
13. Single-Cell Whole Genome Amplification and Sequencing to Study Neuronal Mosaicism and Diversity Patrick J. Reed, Meiyan Wang, Jennifer A. Erwin, Apuг C.M. Paquola, and Fred H. Gage
Part V Genetic and Genomic Mosaicism in Aging and Disease
14. FISH Analysis of Aging-Associated Aneuploidy in Neurons and Non-Neuronal Brain Cells Grasiella A. Andriani and Cristina Montagna
15. Genomic Analysis and In Vivo Functional Validation of Brain Somatic Mutations Leading to Focal Cortical Malformations Jae Seok Lim and Jeong Ho Lee
16. Using Fluorescence In Situ Hybridization (FISH) Analysis to Measure Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative Diseases Julbert Caneus, Antoneta Granic, Heidi J. Chial, Huntington Potter
17. Identification of Low Allele Frequency Mosaic Mutations in Alzheimer Disease Carlo Sala Frigerio, Mark Fiers, Thierry Voet, and Bart De Strooper
Описание: This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.
Описание: Gordon Fain`s Molecular and Cellular Physiology of Neurons, Second Edition is intended for anyone who seeks to understand nerve cell function: undergraduate and graduate students in neuroscience, students of bioengineering and cognitive science, and practicing neuroscientists who want to deepen their knowledge of recent discoveries.
Автор: Paul M. Pilowsky; Melissa M.J. Farnham; Angelina Y Название: Stimulation and Inhibition of Neurons ISBN: 149396268X ISBN-13(EAN): 9781493962686 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Neuromethods series book reviews methods for generating lesions and for stimulating and inhibiting neural pathways, covering new techniques such as optogenetics and the use of the in situ perfused preparation and reassessing well-known approaches.
Автор: Stefan Strack; Yuriy M. Usachev Название: Techniques to Investigate Mitochondrial Function in Neurons ISBN: 1493968882 ISBN-13(EAN): 9781493968886 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Neuromethods Preface... Preface... Table of Contents... Contributing Authors...
1. Three-Dimensional Reconstruction of Neuronal Mitochondria by Electron Tomography Guy Perkins 2. Measuring Mitochondrial Shape with ImageJ Ronald A. Merrill, Kyle H. Flippo, and Stefan Strack 3. Live Imaging Mitochondrial Transport in Neurons Meredith M. Course, Chung-Han Hsieh, Pei-I Tsai, Jennifer A. Codding-Bui, Atossa Shaltouki, and Xinnan Wang 4. Techniques to Investigate Bioenergetics of Mitochondria William I. Sivitz 5. Respirometry in Neurons Liang Zhang and Eugenia Trushina 6. Measuring ATP in Axons with FRET Lauren Y. Shields, Bryce A. Mendelsohn, and Ken Nakamura 7. Characterizing Metabolic States using Fluorescence Lifetime Imaging Microscopy (FLIM) of NAD(P)H Thomas S. Blacker and Michael R. Duchen 8. Techniques for Simultaneous Mitochondrial and Cytosolic Ca2+ Imaging in Neurons Jacob E. Rysted, Zhihong Lin, and Yuriy M. Usachev 9. Live Imaging of Mitochondrial ROS Production and Dynamic Redox Balance in Neurons Karolina Can, Sebastian Kьgler, and Michael Mьller 10. Monitoring of Permeability Transition Pore Openings in Isolated Individual Brain Mitochondria Nickolay Brustovetsky and Tatiana Brustovetsky 11. Examination of Mitochondrial Ion Conductance by Patch Clamp in Intact Neurons and Mitochondrial Membrane Preparations Elizabeth A. Jonas and Nelli Mnatsakanyan 12. Monitoring of Permeability Transition Pore Openings in Mitochondria of Cultured Neurons Tatiana Brustovetsky and Nickolay Brustovetsky 13. Protocols for Assessing Mitophagy in Neuronal Cell Lines and Primary Neurons Ruben K. Dagda and Monica Rice 14. Examining Mitochondrial Function at Synapses In Situ Gregory T. Macleod and Maxim V. Ivannikov 15. Proteomic Analysis of Neuronal Mitochondria Kelly L. Stauch and Howard S. Fox 16. Measuring Mitochondrial Pyruvate Oxidation Lawrence R. Gray, Alix A.J. Rouault, Lalita Oonthonpan, Adam J. Rauckhorst, Julien A. Sebag, and Eric B. Taylor
Автор: Geoffrey Burnstock and Marcello Costa Название: Adrenergic Neurons ISBN: 0412140608 ISBN-13(EAN): 9780412140600 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Strack Stefan, Usachev Yuriy M. Название: Techniques to Investigate Mitochondrial Function in Neurons ISBN: 1493983296 ISBN-13(EAN): 9781493983292 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Neuromethods Preface... Preface... Table of Contents... Contributing Authors...
1. Three-Dimensional Reconstruction of Neuronal Mitochondria by Electron Tomography Guy Perkins 2. Measuring Mitochondrial Shape with ImageJ Ronald A. Merrill, Kyle H. Flippo, and Stefan Strack 3. Live Imaging Mitochondrial Transport in Neurons Meredith M. Course, Chung-Han Hsieh, Pei-I Tsai, Jennifer A. Codding-Bui, Atossa Shaltouki, and Xinnan Wang 4. Techniques to Investigate Bioenergetics of Mitochondria William I. Sivitz 5. Respirometry in Neurons Liang Zhang and Eugenia Trushina 6. Measuring ATP in Axons with FRET Lauren Y. Shields, Bryce A. Mendelsohn, and Ken Nakamura 7. Characterizing Metabolic States using Fluorescence Lifetime Imaging Microscopy (FLIM) of NAD(P)H Thomas S. Blacker and Michael R. Duchen 8. Techniques for Simultaneous Mitochondrial and Cytosolic Ca2+ Imaging in Neurons Jacob E. Rysted, Zhihong Lin, and Yuriy M. Usachev 9. Live Imaging of Mitochondrial ROS Production and Dynamic Redox Balance in Neurons Karolina Can, Sebastian Kьgler, and Michael Mьller 10. Monitoring of Permeability Transition Pore Openings in Isolated Individual Brain Mitochondria Nickolay Brustovetsky and Tatiana Brustovetsky 11. Examination of Mitochondrial Ion Conductance by Patch Clamp in Intact Neurons and Mitochondrial Membrane Preparations Elizabeth A. Jonas and Nelli Mnatsakanyan 12. Monitoring of Permeability Transition Pore Openings in Mitochondria of Cultured Neurons Tatiana Brustovetsky and Nickolay Brustovetsky 13. Protocols for Assessing Mitophagy in Neuronal Cell Lines and Primary Neurons Ruben K. Dagda and Monica Rice 14. Examining Mitochondrial Function at Synapses In Situ Gregory T. Macleod and Maxim V. Ivannikov 15. Proteomic Analysis of Neuronal Mitochondria Kelly L. Stauch and Howard S. Fox 16. Measuring Mitochondrial Pyruvate Oxidation Lawrence R. Gray, Alix A.J. Rouault, Lalita Oonthonpan, Adam J. Rauckhorst, Julien A. Sebag, and Eric B. Taylor
This book describes models of the neuron and multilayer neural structures, with a particular focus on mathematical models. It also discusses electronic circuits used as models of the neuron and the synapse, and analyses the relations between the circuits and mathematical models in detail.
The first part describes the biological foundations and provides a comprehensive overview of the artificial neural networks. The second part then presents mathematical foundations, reviewing elementary topics, as well as lesser-known problems such as topological conjugacy of dynamical systems and the shadowing property. The final two parts describe the models of the neuron, and the mathematical analysis of the properties of artificial multilayer neural networks.
Combining biological, mathematical and electronic approaches, this multidisciplinary book it useful for the mathematicians interested in artificial neural networks and models of the neuron, for computer scientists interested in formal foundations of artificial neural networks, and for the biologists interested in mathematical and electronic models of neural structures and processes.
Описание: The visual system of insects has attracted histologists for a long time. We have detailed histological studies of the visual systems of Diptera, Hymenoptera and Odonata dating from the last century: Leydig's (1864) study on optical ganglia of insects, Ciaccio's (1876) on the fine structure of the first ganglion in the mosquitos and Hickson's (1885) giving for the first time an exact description of the three optical ganglia of Musca. From 1896 several papers appeared using neuro- histological methods, mainly Golgi techniques and methylene blue staining. In 1896 Kenyon published his work on the bee-brain and in 1897 described the relationships of neurons in the optic ganglia with a modified Golgi method. Another work, by Jonescu (1909), should be mentioned: "Vergleichende Unter- suchungen am Gehirn der Honigbiene." In the same year Cajal's findings on the optic ganglia of the fly were published; then in 1915 Cajal and Sanchez wrote a definitive monograph on the neural elements and their connections in the same animal that remained the main reference in this field for decades. In both works Golgi techniques were used. Since then there have been only a few new publications on the subject: (Gribakin, 1967; Perrelet and Baumann, 1969 a, b; Perrelet, 1970; Varela and Porter, 1969; Skrzipek and Skrzipek, 1971, 1973; Grundler, 1972: Snyder, Menzel and Laughlin, 1973). They deal mainly with the receptors of the retina.
Автор: Alain Dabdoub; Bernd Fritzsch; Arthur N. Popper; R Название: The Primary Auditory Neurons of the Mammalian Cochlea ISBN: 1493947303 ISBN-13(EAN): 9781493947300 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A comprehensive review about the spiral ganglion neurons is important for researchers not only in the inner ear field but also in development, neuroscience, biophysics as well as neural networks researchers.
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